Results 51 to 60 of about 3,637,830 (359)

Rough Justice [PDF]

open access: yesHastings Center Report, 2017
AbstractIn the Perspective in this issue of the Hastings Center Report (September‐October 2017), Barron Lerner contrasts the “true believers” in public health schools—“people willing to crusade for any program designed to reduce morbidity and mortality”—and the political operators in the “real world” who often stand in their way.
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Alaska Victimization Survey: Aleutian/Pribilof Islands [PDF]

open access: yes, 2018
This article also appeared on p. 4 of the Spring 2018 print edition.This article provides an overview of key results from the 2014–2015 Alaska Victimization Survey (AVS) for the Aleutian/Pribilof Island region, which was conducted from April to June 2014
UAA Justice Center
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Comparing social stigma of anorexia nervosa, bulimia nervosa, and binge-eating disorder: A quantitative experimental study

open access: yesJournal of Eating Disorders
Background Currently, we know little regarding how stigma attributed to eating disorders compares to that of other psychological disorders and additionally within different types of eating disorders.
Carlye S. Aird   +3 more
doaj   +1 more source

UAA Justice Center 40th Anniversary 1975–2015 [PDF]

open access: yes, 2015
The timeline of selected milestones appearing on pp. 2–3 (split-page format) is also available separately in a single-page format (12.7 x 3.8 in).In celebration of its 40th anniversary, the UAA Justice Center presents a timeline of selected milestones ...
UAA Justice Center
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Wildlife crime: a conceptual integration, literature review, and methodological critique

open access: yesCrime Science, 2017
Wildlife crime, including poaching and wildlife trafficking, threaten the existence of particular species. To date, research on wildlife crime has been primarily conducted by those with backgrounds in the biological sciences, however crime scientists ...
Justin Kurland   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy