Results 61 to 70 of about 222,060 (267)

Co-ownership and Collaboration: Insights into the Measurement of Impact and Change from Evidence-Based Community and State Violence Prevention Partnerships

Stability : International Journal of Security and Development, 2015
Effective partnerships in community crime and violence prevention interventions are challenging to foster. While this may be the case, their merits cannot be denied, thus it is necessary to involve diverse stakeholders in processes that aim to address ...
Tariro Mutongwizo, Lezanne Leoschut, Patrick Burton   +2 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Integrating local perceptions and meteorological data to examine climate change trends among mobile pastoralists in North-western Ghana

Environmental Systems Research
Climate change has garnered significant attention since the late twentieth century owing to the risks it poses to all sectors of the global economy, particularly mobile pastoralism.
Justice Aduko
doaj   +1 more source

The validity of open-source data when assessing jail suicides

Health & Justice, 2018
Background The Bureau of Justice Statistics’ Deaths in Custody Reporting Program is the primary source for jail suicide research, though the data is restricted from general dissemination.
Amanda L. Thomas, Jacqueline Scott, Jeff Mellow   +2 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

ANALYSIS AND PROSPECTS OF ENSURING NATIONAL ECONOMIC SECURITY IN THE CONTEXT OF THE MODERN PARADIGM OF ECONOMIC SANCTIONS

Наука Красноярья
The article considers and substantiates a set of measures to ensure economic security in modern, sanctioned economic conditions, which can include: the results of the impact of a package of sanctions from unfriendly foreign states in the period from 2022-
Elena N. Syshchikova, Marina V. Bogdanova, Ekaterina E. Makarova   +2 more
doaj   +1 more source

Justice: Theories of

, 2015
All justice ethics aim at finding balance between liberty and equality, between individual autonomy and the common good. However, each raises objections that demonstrate their own limitations. Three paradigms in which the theories fit will be presented, as well as four models that illustrate how the theories apply to bioethical problems.
Renaud, Michel, Águas, Cíntia
openaire   +2 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The Impact of the State Policy of the Russian Federation in the Field of Demography and Health-Care on the Quality of Life of the Population

RUDN Journal of Public Administration
The study examines the features of state policy in the field of demography and health care, special attention is paid to the analysis of the main indicators of the quality of life of the population, as well as the results already achieved within the ...
Margarita V. Alexandrova, Ekaterina A. Maslyukova, Olga V. Yutkina   +2 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source