Results 101 to 110 of about 54,427 (263)

The development and assessment of biological treatments for children [PDF]

, 2014
The development of biological agents with specific immunological targets has revolutionized the treatment of a wide variety of paediatric diseases where traditional immunosuppressive agents have been partly ineffective or intolerable.
Akobeng, Alexeeva, Alvarez, Andborn, Anink, Baldassano, Biester, Borker, Bout-Tabaku, Braun, Brennan, Brunner, Callen, Caorsi, Cezard, Choueiter, Choy, Cleary, Colombel, Crandall, De Benedetti, De Benedetti, De Cassan, Eberhard, Eleftheriou, Feagan, Fernandes, Fleischmann, Furie, Gasparetto, Gattorno, Gerloni, Giannini, Giannini, Hanauer, Hashkes, Horneff, Horneff, Horneff, Horneff, Horneff, Horneff, Hyams, Hyams, Hyams, Irvine, Jansson, Kahn, Kanakoudi-Tsakalidou, Kaneko, Kavanaugh, Kingsbury, Kok, Kuemmerle-Deschner, Kusuhara, Kutukculer, Lehman, Lehman, Lepore, Lequerre, Lin, Lofgren, Lovell, Lovell, Lovell, Lovell, Lovell, Lovell, Lowite, Luu, Mangge, Mohler, Munro, Myers, Navarra, Nigrovic, Otten, Paller, Papsdorf, Podolskaya, Prince, Prince, Quartier, Quartier, Quatrier, Robinson, Rosenbach, Rosh, Rothner, Ruemmele, Runner, Ruperto, Ruperto, Ruperto, Ruperto, Ruperto, Russell, Sakallioglu, Sandborn, Sandborn, Simard, Simonini, Southwood, Swart, Taylor, Toussi, Tynjala, Uperto, Vermeire, Viola, Wallace, Walters, Willems, Wyneski, Yokota, Yokota, Zannin, Zeft, Zulian   +118 more
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Clinical predictors of proteinuric remission following an LN flare - evidence from the UK JSLE cohort study

Pediatric Rheumatology Online Journal, 2018
Background Proteinuria is a well-known risk factor for progression of renal dysfunction in a variety of chronic kidney diseases. In adult-onset Systemic Lupus Erytematosus (SLE) patients with lupus nephritis (LN), proteinuria takes a significant period ...
Eve M. D. Smith, Peng Yin, Andrea L. Jorgensen, Michael W. Beresford, on behalf of the UK JSLE Study Group   +4 more
doaj   +1 more source

Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update. [PDF]

, 2019
Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a growth factor that induces the differentiation and proliferation of myeloid progenitors in the bone marrow.
Adorini, Ahn, Alnek, Ananthakrishnan, Aram, Aricha, Basdeo, Bernasconi, Bezbradica, Bhattacharya, Bhattacharya, Bogunovic, Borriello, Campbell, Cao, Casciola-Rosen, Cheatem, Chiewchengchol, Choi, Chuang, Ciric, Codarri, Cook, Cook, Coombes, Croxford, Denson, Derouet, Dieckgraefe, Duhen, Egea, El-Behi, Enzler, Fernandes, Fillatreau, Fraussen, Fuchs, Ganesan, Ganesh, Gangi, Gao, Gathungu, Gaudreau, Ghosh, Gonzalez, Gopisetty, Hansen, Harrington, Hartmann, Hirota, Hirota, Hirota, Huang, Imitola, Jain, Kared, Karni, Kaskow, Katano, Katz, Kelly, Kenkel, King, King, Kister, Lebre, Lee, Lehtonen, Leizer, Li, Li, Li, Li, Makris, Marks, Matsuyama, Mausberg, McWilliams, Meriggioli, Midgley, Mikita, Mufazalov, Muranski, Nagane, Noster, Ortega, Parajuli, Pare, Pare, Park, Piper, Ponomarev, Poppensieker, Ramos-Levi, Rasouli, Reynolds, Roelofs, Rowin, Sakaguchi, Salehi, Samarpita, Scholz, Schutt, Serafini, Shang, Shapouri-Moghaddam, Sheng, Sheng, Sheng, Shiomi, Shiomi, Shiomi, Smith, Srenathan, Stojic-Vukanic, Surendar, Tavakolpour, Touil, Tsark, van de Laar, van Nieuwenhuijze, Vasu, Vincent, Vincent, Vogel, Waisman, Wicks, Wiggins-Dohlvik, Willeke, Xu, Xu, Yang, York, Zhang, Zhao   +134 more
core   +2 more sources

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, EarlyView.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Hepatitis C virus antibodies in high risk juvenile onset systemic lupus erythematosus

Revista Brasileira de Reumatologia, 2016
Objective To evaluate the prevalence of hepatitis C virus (HCV) infection in high risk juvenile systemic lupus erythematosus (JSLE). Study design Forty low income JSLE patients (6M:34F; mean age 19 ± 4.4 yrs; mean disease duration 6 ± 3.2 yrs) were ...
Nádia E. Aikawa, Ana P. Nascimento, André L.S. Hayata, Eloisa Bonfá, Cláudia Goldenstein-Schainberg   +4 more
doaj   +1 more source

Juvenile idiopathic inflammatory myopathies: the value of magnetic resonance imaging in the detection of muscle involvement [PDF]

, 2000
CONTEXT: One of the major current challenges related to juvenile idiopathic inflammatory myopathy is the search for highly sensitive and specific non-invasive methods for diagnosis as well as for follow-up.
Hilário, Maria Odete Esteves, Lederman, Henrique Manoel, Len, Claudio Arnaldo, Lutti, Daniela, Terreri, Maria Teresa Ramos Ascensão, Yamashita, Helio Kiitiro   +5 more
core   +4 more sources

Periodontitis and Periodontal Conditions in Systemically Healthy Children and Adolescents

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Objective To answer the PICoS question ‘in systemically healthy children and adolescents (Population), what are the main features of periodontitis, necrotising periodontal diseases (NPD) and other periodontal conditions (periodontal abscesses, endo‐periodontal lesions, traumatic occlusal forces, prosthesis‐ and tooth‐related factors ...
Inbar Eshkol‐Yogev, Nagore Ambrosio, Cheryl Somani, Elena Figuero, Lior Shapira, Janet Davies   +5 more
wiley   +1 more source

Belimumab in the treatment of systemic lupus erythematosus with juvenile onset: Results of a single-center retrospective study

Научно-практическая ревматология
The treatment of systemic lupus erythematosus with juvenile onset (jSLE) remains a difficult task, taking into account the more aggressive course of the disease, requiring the appointment of various therapy regimens, including mainly a combination of ...
Maria I. Kaleda, Irina P. Nikishina, Tamari N. Pachkoria, Anna N. Shapovalenko   +3 more
doaj   +1 more source

NEUROPSYCHIATRIC DISORDERS IN JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS FROM A RETROSPECTIVE STUDY

Научно-практическая ревматология, 2020
Objective: to analyze clinical features and immunological abnormalities in juvenile-onset systemic lupus erythematosus (SLE) with neurolupus and to compare findings with the data available in the literature.Subjects and methods.
M. I. Kaleda, I. P. Nikishina, S. I. Glukhova, N. Yu. Stepanenko   +3 more
doaj   +1 more source