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Juvenile-Onset Systemic Lupus Erythematosus: Update on Clinical Presentation, Pathophysiology and Treatment Options [PDF]

Clinical Immunology, 2019
Juvenile-onset systemic lupus erythematosus (jSLE) accounts for up to 20% of all SLE patients. Key differences between juvenile- and adult-onset (aSLE) disease include higher disease activity, earlier development of damage, and increased use of ...
Christian M Hedrich, Michael W Beresford, Hanna Lythgoe   +2 more
exaly   +2 more sources

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Ocular Manifestations in Children with Juvenile-Onset Systemic Lupus Erythematosus

Seminars in Ophthalmology, 2017
To study the ocular manifestations of juvenile systemic lupus erythematosus (JSLE), including the ocular side-effects of the systemic medications used.A descriptive cross-sectional study on 40 children diagnosed with JSLE was conducted. Ophthalmological and laboratory investigations as well as a calculation of the Systemic Lupus Disease Activity Index ...
Ghada, Gawdat, Dina, El-Fayoumi, Huda, Marzouk, Yomna, Farag   +3 more
openaire   +2 more sources

Pulmonary hypertension in juvenile-onset systemic lupus erythematosus: a case series

Clinical and Experimental Rheumatology, 2022
Systemic lupus erythematosus (SLE) is a rare multisystem autoimmune disorder with a variable clinical phenotype. Pulmonary hypertension (PHTN) is a recognised (and not uncommonly asymptomatic) complication of the condition with an associated poor prognosis in adults.
Platt, Caroline, Longthorpe, Catherine, Sit, Jacqueline, Marks, Stephen D, Harmer, Matthew, Ciurtin, Coziana, Ramanan, Athimalaipet V, Beresford, Michael W   +7 more
openaire   +3 more sources

Anti‐C1q Antibodies in Juvenile‐Onset Systemic Lupus Erythematosus

Annals of the New York Academy of Sciences, 2009
The objective of this study was to evaluate the presence of anti‐C1q antibodies Hospital Israelita Albert Einstein Research Institute, São Paulo, Brazil in 67 juvenile systemic lupus erythematosus (JSLE) patients and 26 healthy controls and to assess the association of these antibodies with disease activity, nephritis, and presence of anti‐double ...
A A, Jesus, C A, Silva, M, Carneiro-Sampaio, M, Sheinberg, C L, Mangueira, S K, Marie, B L, Liphaus   +6 more
openaire   +2 more sources

SAT0277 Neuropsychiatric Involvement in Juvenile-Onset Systemic Lupus

Annals of the Rheumatic Diseases, 2016
Background Neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) includes the neurological syndromes of the central, peripheral or autonomic nervous systems and psychiatric disorders. Some studies suggests that juvenile systemic lupus erythematosus (jSLE) has a more serious course and a more frequent neuropsychiatric involvement than ...
R. Fonseca, F. Aguiar, M. Rodrigues, I. Brito   +3 more
openaire   +1 more source

THU0330 Damage in juvenile-onset systemic lupus erythematosus

Annals of the Rheumatic Diseases, 2012
Background Children and adolescents with juvenile-onset systemic lupus erythematosus (jSLE) face considerable morbidity due to sequelae of disease activity, comorbidities and adverse effects of treatment. In order to improve the management of these patients, it is essential to better understand the risk factors associated with the development of ...
P. Costa Reis, J. Isgro, S. Nativ, C. Yildirim-Toruner, A. Starr, L. Imundo, A. Eichenfield   +6 more
openaire   +1 more source

Analysis of serum IL-38 in juvenile-onset systemic lupus erythematosus

Modern Rheumatology, 2018
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with widespread immunologic abnormalities and multiple organ involvement [1].
Yusuke, Takeuchi, Tomoko, Seki, Norimoto, Kobayashi, Kenji, Sano, Tomonari, Shigemura, Hisashi, Shimojo, Kazuhiko, Matsumoto, Kazunaga, Agematsu   +7 more
openaire   +2 more sources

Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus

Annals of the Rheumatic Diseases, 2014
This study tested the concurrent validity of the systemic lupus erythematosus responder index (SRI) in assessing improvement in juvenile-onset systemic lupus erythematosus (jSLE).The SRI considers changes in the SELENA-SLEDAI, BILAG and a 3-cm visual analogue scale of physician-rated disease activity (PGA) to determine patient improvement.
Mina R, Klein Gitelman MS, Nelson S, Eberhard BA, Higgins G, Singer NG, Onel K, Tucker L, O'Neil KM, Punaro M, Levy DM, Haines K, MARTINI, ALBERTO, Ruperto N, Lovell D, Brunner HI   +15 more
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Multi-disciplinary care in juvenile-onset systemic lupus erythematosus

British Journal of School Nursing, 2012
Juvenile onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease that can affect any part of the body including skin, joints and organs and can be associated with significant morbidity and mortality. Multi-disciplinary care of children and young people with JSLE is essential, in close partnership with schools.
Jane Kelly, Jane Dunnage, Michael W Beresford, Liza J McCann   +3 more
openaire   +1 more source

Type I Interferon Associated Epistasis May Contribute to Early Disease-Onset and High Disease Activity in Juvenile-Onset Lupus

Clinical Immunology
Pathologic type I interferon (T1IFN) expression is a key feature in systemic lupus erythematosus (SLE) that associates with disease activity. When compared to adult-onset disease, juvenile-onset (j)SLE is characterized by increased disease activity and ...
Yves Renaudineau, Valentina Natoli, Amandine Charras   +2 more
exaly   +2 more sources