Results 31 to 40 of about 2,958 (128)
Stem Cell Research, 2018 Juvenile Onset Huntington's Disease (JOHD) is a rare variant of HD withage of onset ≤20 years, accounting for 3–10% of all HD patients. The rarity occurrence of JOHD cases, who severely progress towards mental and physical disability with atypical ...
Giovannina Rotundo +12 more
doaj +1 more source
Biomolecules, 2022 Cranial radiation therapy is one of the most effective treatments for childhood brain cancers. Despite the ameliorated survival rate of juvenile patients, radiation exposure-induced brain neurogenic region injury could markedly impair patients’ cognitive
Dong Liang +6 more
doaj +1 more source
Gender &History, EarlyView.ABSTRACT The contributions of propagandist and writer Hildegart (1914–1933) to Spanish cultural life are overshadowed by accounts of her unusual upbringing and violent death. This article examines the conditions that enabled the teenager to become a prominent voice for feminism and sexual reform on the eve of Spain's Second Republic (1931–1939).
Micaela Pattison
wiley +1 more source
BMC Neurology, 2021 Background Recent advances in therapeutic options may prevent deterioration related to Huntington’s disease (HD), even at the pre-symptomatic stage. Be that as it may, a well-characterized patient population is essential for screening and monitoring ...
Katalin Despotov +10 more
doaj +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells. [PDF]
PLoS ONE, 2016 Mutations of the huntingtin protein (HTT) gene underlie both adult-onset and juvenile forms of Huntington's disease (HD). HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone.
Carla Lopes +7 more
doaj +1 more source
Mapping the Young‐Onset Dementia Research in the Asia‐Pacific Region: A Scoping Review
Asia-Pacific Psychiatry, Volume 18, Issue 3, September 2026.ABSTRACT Young‐onset dementia (YOD), with symptom onset before 65, is an area of increasing public health importance. YOD research in Asia‐Pacific remains under‐represented in the global YOD research landscape. This scoping review aimed to comprehensively map the existing YOD literature from Asia‐Pacific and provide an overview of the research topics ...
Gia Tan +15 more
wiley +1 more source
Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 36, Issue 8, August 2026.ABSTRACT Active coral reef restoration incorporates ecological engineering principles. Yet, the spatial arrangement of transplanted colonies, one of the few design parameters directly controlled by practitioners, remains poorly explored empirically. We conducted a systematic review following PRISMA guidelines to evaluate how clustered (high‐density ...
Dor Shefy +3 more
wiley +1 more source
Effect of Ayurvedic interventions as add-on therapy in Huntington's disease: A case report
Journal of Ayurveda Case Reports, 2022 Huntington's disease (HD) is a rare autosomal dominant neurodegenerative disorder. It is caused due to trinucleotide cytosine-adenine-guanine (CAG) repeat expansion on chromosome 4.
B Malavika, HP Savitha
doaj +1 more source
Animal Research and One Health, Volume 4, Issue 3, Page 278-292, August 2026.This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou +4 more
wiley +1 more source