Results 51 to 60 of about 2,915 (110)

CRISPR Cas systems: From bacterial defense mechanisms to revolutionary tools reshaping genetic research and translation therapeutics

The Microbe
The CRISPR-Cas systems, initially identified as bacterial defense mechanisms, have become innovative tools for genetic research and translational therapeutics. These systems are made up of clustered regularly interspaced short palindromic repeats (CRISPR)
Kamran Saeed, Faisal Ayub, Muhammad Arshad Durrani, Muhammad Mujahid   +3 more
doaj   +1 more source

Managing juvenile Huntington's disease. [PDF]

Neurodegener Dis Manag, 2013
Quarrell OW, Nance MA, Nopoulos P, Paulsen JS, Smith JA, Squitieri F.   +5 more
europepmc   +1 more source

Clinical Review of Juvenile Huntington's Disease. [PDF]

J Huntingtons Dis
Oosterloo M, Touze A, Byrne LM, Achenbach J, Aksoy H, Coleman A, Lammert D, Nance M, Nopoulos P, Reilmann R, Saft C, Santini H, Squitieri F, Tabrizi S, Burgunder JM, Quarrell O, Pediatric Huntington Disease Working Group of the European Huntington Disease Network.   +16 more
europepmc   +1 more source

Intrathecal baclofen pump for severe hypertonia in a patient with juvenile Huntington's disease: illustrative case. [PDF]

J Neurosurg Case Lessons
Winston GM, Nilchian P, Greenfield JP, Jones D.   +3 more
europepmc   +1 more source

Juvenile Huntington's Disease Skin Fibroblasts Respond with Elevated Parkin Level and Increased Proteasome Activity as a Potential Mechanism to Counterbalance the Pathological Consequences of Mutant Huntingtin Protein. [PDF]

Int J Mol Sci, 2019
Aladdin A, Király R, Boto P, Regdon Z, Tar K.   +4 more
europepmc   +1 more source

Neuropathological Comparison of Adult Onset and Juvenile Huntington's Disease with Cerebellar Atrophy: A Report of a Father and Son. [PDF]

J Huntingtons Dis, 2017
Latimer CS, Flanagan ME, Cimino PJ, Jayadev S, Davis M, Hoffer ZS, Montine TJ, Gonzalez-Cuyar LF, Bird TD, Keene CD.   +9 more
europepmc   +1 more source

Update on Genetic Chorea. [PDF]

Curr Neurol Neurosci Rep
Ostrozovicova M, Skorvanek M.
europepmc   +1 more source

Dysregulation of store-operated calcium entry in fibroblast lines from adult and juvenile-onset Huntington's disease patients. [PDF]

Pharmacol Rep
Egbuwalo SO, Latoszek E, Hansíková H, Hansíková H, Klempíř J, Mühlbäck A, Landwehrmeyer GB, Kuźnicki J, Czeredys M.   +8 more
europepmc   +1 more source

Huntington's disease human lateral ganglionic eminence precursors differentiate into functionally mature medium spiny neurons exhibiting pathology. [PDF]

Stem Cells
McCaughey-Chapman A, Connor B.
europepmc   +1 more source

Genetic Profiling of Huntington's Disease: Insights from CAG Repeat Analysis for Precision Diagnosis and Management. [PDF]

Noro Psikiyatr Ars
Canbek S, Manazoğlu HC, Dinçtürk Y, Aydın B, Yarar MH, Eser M.   +5 more
europepmc   +1 more source