Juvenile localized scleroderma: review of 44 patients [PDF]
Pediatric Rheumatology Online Journal, 2011 Predominant form of childhood sclerosis is localized scleroderma (LSc) or morphoea. Preliminary classification includes circumscribed morphoea (CM), linear scleroderma (LS), generalized (GM), panclerotic (PM) and mixed morphoea (MM). The major problem in untreated patients is morbidity, so the aim of the therapy is to prevent this.
Iglesias E +7 more
doaj +11 more sources
Long-term methotrexate efficacy in juvenile localized scleroderma [PDF]
Pediatric Rheumatology Online Journal, 2011 Methods We prospectively followed a cohort of patients with JLS who were enrolled in a double-blind, randomized controlled trial. Oral MTX was used at a dose of 15 mg/m once a week (max 20 mg) for at lest 24 months; prednisone (1 mg/Kg/day, max 50 mg), in a single morning dose for 3 months was added.
Giuliotto S +5 more
doaj +12 more sources
Mycophenolate mofetil for methotrexate-resistant juvenile localized scleroderma. [PDF]
Rheumatology (Oxford), 2021 Objectives: To investigate safety and efficacy of MMF in patients with severe or MTX-refractory juvenile localized scleroderma. Methods: Consecutive juvenile localized scleroderma patients undergoing systemic treatment were included in a retrospective ...
Martini G +5 more
europepmc +8 more sources
Connective tissue nevus misdiagnosed as juvenile localized scleroderma [PDF]
Pediatric Rheumatology Online Journal, 2023 Background Connective tissue nevi (CTN) are congenital hamartomas caused by excessive proliferation of dermis components. In children, CTN can mimic juvenile localized scleroderma (JLS), an immune mediated skin disorder that requires aggressive ...
F. Tirelli +7 more
doaj +7 more sources
Juvenile Localized Scleroderma with Hyaline Deposits in the Renal Arteriole [PDF]
Case Reports in Dermatology, 2018 We report a 10-year-old boy with localized scleroderma of the linear and plaque type, who showed proteinuria and hematuria. In this patient, skin, articular, and renal manifestations appeared successively and then began to resolve in the same order.
Nobuko Tabata, Chiyoko Nagano Inoue
doaj +6 more sources
Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry [PDF]
ACR Open Rheumatology, 2019 Objective Localized scleroderma (LS) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile LS (jLS) cohort from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, a multicenter ...
Eveline Y. Wu +6 more
doaj +3 more sources
Juvenile localized scleroderma: a large retrospective cohort study from a tertiary care center [PDF]
Pediatric Rheumatology Online JournalBackground Juvenile localized scleroderma is a rare pediatric inflammatory disease that primarily affects the skin and subcutaneous tissue but also has the potential to impact deeper tissues and can be associated with extracutaneous manifestations ...
Bugra Han Egeli +8 more
doaj +4 more sources
Juvenile Localized Scleroderma. Questions of Treatment
Вопросы современной педиатрии, 2020 Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS.
Rinat K. Raupov, Mikhail M. Kostik
doaj +9 more sources
Reliability of LoSCAT score for activity and tissue damage assessment in a large cohort of patients with Juvenile Localized Scleroderma [PDF]
Pediatric Rheumatology Online Journal, 2018 Objectives To assess reliability of the two indexes of Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), the modified Localized Scleroderma Skin Severity Index (mLoSSI) and the Localized Scleroderma Skin Damage Index (LoSDI), when applied by ...
Anna Agazzi +4 more
doaj +4 more sources
Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma. [PDF]
Arthritis Care Res (Hoboken), 2017 ObjectiveLocalized scleroderma can negatively affect children's quality of life (QoL), but predictors of impact have not been well described. We sought to identify predictors of QoL impact in juvenile localized scleroderma patients.MethodsWe analyzed longitudinal data from a single‐center cohort of juvenile localized scleroderma patients, using ...
Ardalan K, Zigler CK, Torok KS.
europepmc +6 more sources