Mycophenolate mofetil for methotrexate-resistant juvenile localized scleroderma [PDF]
AbstractObjectivesTo investigate safety and efficacy of MMF in patients with severe or MTX-refractory juvenile localized scleroderma.MethodsConsecutive juvenile localized scleroderma patients undergoing systemic treatment were included in a retrospective longitudinal study.
Giorgia Martini +2 more
exaly +5 more sources
Juvenile localized scleroderma with autoimmune thyroid disorder
Hiremath N +5 more
doaj +4 more sources
Juvenile Localized Scleroderma. Questions of Treatment
Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS.
Rinat K. Raupov, Mikhail M. Kostik
doaj +9 more sources
Juvenile localized scleroderma: review of 44 patients [PDF]
Predominant form of childhood sclerosis is localized scleroderma (LSc) or morphoea. Preliminary classification includes circumscribed morphoea (CM), linear scleroderma (LS), generalized (GM), panclerotic (PM) and mixed morphoea (MM). The major problem in untreated patients is morbidity, so the aim of the therapy is to prevent this.
Iglesias E +7 more
doaj +4 more sources
Long-term methotrexate efficacy in juvenile localized scleroderma [PDF]
Methods We prospectively followed a cohort of patients with JLS who were enrolled in a double-blind, randomized controlled trial. Oral MTX was used at a dose of 15 mg/m once a week (max 20 mg) for at lest 24 months; prednisone (1 mg/Kg/day, max 50 mg), in a single morning dose for 3 months was added.
Giuliotto S +5 more
doaj +4 more sources
New Challenging Systemic Therapies for Juvenile Scleroderma: A Comprehensive Review [PDF]
Background: Juvenile scleroderma (JS) comprises a group of rare chronic autoimmune and fibrosing disorders in children, primarily presenting as juvenile localized scleroderma (jLS) or juvenile systemic sclerosis (jSS). While jLS predominantly affects the
Chiara Sassetti +5 more
doaj +2 more sources
Durometry as an outcome measure in juvenile localized scleroderma. [PDF]
Poff S +4 more
europepmc +4 more sources
Juvenile eosinophilic fasciitis: a single center case series [PDF]
Background Eosinophilic fasciitis (EF) is a rare disease characterized by skin induration and musculoskeletal abnormalities. Diagnostic criteria for EF are based on adult populations.
Leigh A. Stubbs +9 more
doaj +2 more sources
Reliability of using an ultrasound scoring measure for juvenile localized scleroderma (jLS) [PDF]
Li Suzanne C +13 more
doaj +2 more sources
Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. [PDF]
AbstractObjectiveJuvenile localized scleroderma (LS) is a chronic inflammatory skin disorder associated with substantial morbidity and disability. Although a wide range of therapeutic strategies has been reported in the literature, a lack of agreement on treatment specifics and accepted methods for clinical assessment has made it difficult to compare ...
Li SC +24 more
europepmc +4 more sources

