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Challenges and complications in juvenile localized scleroderma: A practical approach
Best Practice and Research in Clinical RheumatologyJuvenile localized scleroderma is characterised by inflammation which drives fibrosis in skin and soft tissues. The more severe subtypes of localized scleroderma such as linear and craniofacial are more common in children. Additionally, extracutaneous involvement is seen in half of all children and is associated with poorer treatment outcomes and ...
Kathryn Torok, Clare E Pain
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Juvenile Scleroderma-What has Changed in the Meantime?
Current Rheumatology Reviews, 2018 Background: Juvenile scleroderma is a rarely seen chronic connective tissue disorder characterized by stiffening of the skin. The frequency of the disease was reported as one per million.
Kenan Barut +2 more
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Juvenile Localized and Systemic Scleroderma
2016Juvenile localized scleroderma and juvenile systemic sclerosis (jSSc) are sclerotic disorders which differ greatly in their extent of involvement and prognosis. Juvenile localized scleroderma, also called morphea, involves the skin and subcutaneous tissues. It occurs in 4.7–20 per 100,000 children and is ten times more frequent than jSSc. Lesions range
Lauren V. Graham +2 more
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Juvenile localized scleroderma: A single‐centre experience from India
Journal of the European Academy of Dermatology and Venereology, 2022AbstractBackgroundJuvenile localized scleroderma (JLS) or morphoea, a rare chronic autoimmune disease predominantly affects skin, subcutaneous tissue and occasionally the adjacent muscle, fascia and bone. We report the largest single‐centre cohort of patients with JLS from India.MethodsPatients who were diagnosed to have JLS were enrolled from the ...
Ankur Kumar Jindal +11 more
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Juvenile Localized Scleroderma
2011Juvenile localized scleroderma (JLS), known as morphea, comprises a group of conditions which involve essentially the skin and subcutaneous tissues. They have various features and range from very small plaques to extensive fibrotic lesions which may cause significant functional changes and cosmetic deformities.
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Treatment of juvenile localized scleroderma with upadacitinib: A case series
Journal of the European Academy of Dermatology and VenereologyYonghu Sun
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OP0292 Therapeutic Strategies for Juvenile Localized Scleroderma
Annals of the Rheumatic Diseases, 2015Background Juvenile localized scleroderma (JLS) is a chronic inflammatory fibrosing disorder with numerous disease subtypes, results in deep tissue atrophy, limited functional capacity. Treatment of jLS is still contraversal, ranges from topical skin management to immunosuppressive therapy (IST).
M. Osminina +5 more
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Juvenile Localized Scleroderma
Rheumatic Disease Clinics of North America, 2021Natalia Vasquez-Canizares, Suzanne C. Li
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[Juvenile localized scleroderma].
Dermatologie (Heidelberg, Germany)Juvenile scleroderma, often referred to as juvenile localized scleroderma or "morphea", is a rare inflammatory disease of the skin and skin-related structures, accompanied by local sclerosis and tissue fibrosis. Depending on the clinical manifestation, four different subtypes can be defined: limited, generalized, linear, and mixed.
Timmy, Strauss +2 more
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The burden of extracutaneous manifestations in juvenile localized scleroderma: A literature review
Autoimmunity ReviewsJuvenile Localized Scleroderma (JLS) is an autoimmune disease leading to fibrosis of skin and subcutaneous tissues affecting children, that is characterized by extracutaneous manifestations (ECM) in about 20 % of patients. JLS and ECM can cause severe disabilities, potentially impacting patients' quality of life (QoL). We aimed to systematically review
Liguoro I., Simonini G., Martini G.
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