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Musculoskeletal MRI findings of juvenile localized scleroderma
Pediatric Radiology, 2017Juvenile localized scleroderma comprises a group of autoimmune conditions often characterized clinically by an area of skin hardening. In addition to superficial changes in the skin and subcutaneous tissues, juvenile localized scleroderma may involve the deep soft tissues, bones and joints, possibly resulting in functional impairment and pain in ...
Eric P, Eutsler +4 more
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DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma
Clinical Immunology, 2021Scleroderma refers to a group of chronic fibrotic immune-mediated diseases of unknown etiology. Characterizing epigenetic changes in childhood-onset scleroderma, systemic sclerosis or localized scleroderma, has not been previously performed. The aim of this study was to assess DNA methylation differences and similarities between juvenile systemic ...
Patrick, Coit +4 more
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New Developments in Juvenile Systemic and Localized Scleroderma
Rheumatic Disease Clinics of North America, 2013Juvenile localized scleroderma (jLS) and juvenile systemic sclerosis (jSS) are both orphan diseases, with jLS around 10 times more frequent than jSS. In recent years the time gap between the appearance of symptoms and diagnosis has become significantly shorter.
Ivan Foeldvari
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Challenges and complications in juvenile localized scleroderma: A practical approach
Best Practice & Research Clinical RheumatologyJuvenile localized scleroderma is characterised by inflammation which drives fibrosis in skin and soft tissues. The more severe subtypes of localized scleroderma such as linear and craniofacial are more common in children. Additionally, extracutaneous involvement is seen in half of all children and is associated with poorer treatment outcomes and ...
Clare E. Pain, Kathryn S. Torok
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Systemic therapy in juvenile localized scleroderma
Expert Review of Clinical Immunology, 2023Juvenile localized scleroderma (JLS) is a rare sclerosing disorder of childhood which can result in permanent morbidity and functional disability, if not effectively treated. Treatment should be started in the inflammatory phase before the development of any complication and/or damage.In this review, we will discuss how to assess disease activity and ...
Ivan Foeldvari, Edoardo Marrani
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Predictors of family impact of juvenile localized scleroderma
Pediatric Dermatology, 2021AbstractObjectiveTo measure the impact juvenile localized scleroderma (jLS) has on family quality of life and to identify predictors of family impact in this population which may inform the development of tailored resources to enhance family functioning for patients with jLS.MethodsA retrospective cohort study of pediatric patients with jLS and their ...
Katia Milovanova +5 more
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Juvenile localized scleroderma: A single‐centre experience from India
Journal of the European Academy of Dermatology and Venereology, 2022AbstractBackgroundJuvenile localized scleroderma (JLS) or morphoea, a rare chronic autoimmune disease predominantly affects skin, subcutaneous tissue and occasionally the adjacent muscle, fascia and bone. We report the largest single‐centre cohort of patients with JLS from India.MethodsPatients who were diagnosed to have JLS were enrolled from the ...
Ankur Kumar Jindal +11 more
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BILATERAL CHOROIDAL EXCAVATION IN JUVENILE LOCALIZED SCLERODERMA
RETINAL Cases & Brief Reports, 2018Purpose: To describe a case of bilateral choroidal excavation in a patient with juvenile localized scleroderma. Methods: Case report. Results: An asymptomatic 12-year-old boy with localized scleroderma presented for examination and was ...
Mackenzie L, Franklin, Shelley, Day
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Overview of Juvenile localized scleroderma and its management
World Journal of Pediatrics, 2019Juvenile localized scleroderma (JLS) is a rare pediatric disease characterized by inflammation and skin thickening. JLS is associated with deep tissue and extracutaneous involvement that often results in functional impairment and growth disturbances.
Suzanne C. Li, Rong-Jun Zheng
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Juvenile localized scleroderma: Is it a benign disease?
Revista Colombiana de Reumatología (English Edition), 2017Abstract Introduction Juvenile localized scleroderma is a polymorphic disease. It is more prevalent in girls and has a significant morbidity. Extra-cutaneous involvement is common, and polyautoimmunity can reach 7%. The clinical characteristics of this disease in Colombian patients are currently unknown.
Christine Arango +6 more
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