Results 31 to 40 of about 9,585 (206)
New Challenging Systemic Therapies for Juvenile Scleroderma: A Comprehensive Review [PDF]
PharmaceuticalsBackground: Juvenile scleroderma (JS) comprises a group of rare chronic autoimmune and fibrosing disorders in children, primarily presenting as juvenile localized scleroderma (jLS) or juvenile systemic sclerosis (jSS). While jLS predominantly affects the
Chiara Sassetti +5 more
doaj +2 more sources
Вопросы современной педиатрии, 2020 The localized scleroderma (morphea) is the clinical option of the juvenile scleroderma, the third in prevalence rheumatic condition in pediatrics. The article summarizes all the data on the classification, diagnostics, and differential diagnosis of ...
Rinat K. Raupov +2 more
doaj +3 more sources
Zdorovʹe Rebenka, 2019 Among rheumatic diseases in children, a special place belongs to juvenile localized scleroderma, which is highlighted as a separate form in the structure of scleroderma diseases and is characterized by: the onset of the disease up to 16 years, skin ...
L.F. Bogmat, V.V. Nikonova
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Juvenile localized scleroderma: beyond our eyes can see
Residência PediátricaINTRODUÇÃO: Esclerodermia localizada juvenil (ELJ) é a forma mais comum de esclerodermia na infância e representa um grupo de entidades clínicas distintas, com espessamento de epiderme, derme e tecido subcutâneo adjacente.
A. V. C. Almeida +6 more
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Endpoints and outcomes for localized scleroderma/morphea: a scoping literature review [PDF]
Pediatric Rheumatology Online JournalBackground Current treatment for localized scleroderma (LS) has been shown to halt disease activity, but little is still known about patient experiences with these treatments, nor is there consensus about optimal measurement strategies for future ...
Alexy Hernandez +5 more
doaj +2 more sources
Exploring the Association of Sociodemographic Factors and Primary Diagnosis With Transition Readiness in Adolescents With Rheumatic Disease. [PDF]
ACR Open RheumatolObjective Transitioning from pediatric to adult care is challenging for adolescents with chronic health conditions. The Transition Readiness Assessment Questionnaire (TRAQ) is a validated tool for measuring transition readiness in pediatric patients with chronic diseases.
Al Manaa M +6 more
europepmc +2 more sources
Current medical imagingBACKGROUND Although clinical assessment has historically been the primary method used for pediatric localized sclerosis (LS) diagnosis and staging, highfrequency ultrasonography (HFUS) is being investigated as a more accurate evaluation method for lesion.
Şeyma Türkmen +2 more
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3233 Von Willebrand Factor is Localized in the Extravascular tissue of Patients with Juvenile Scleroderma [PDF]
Journal of Clinical and Translational Science, 2019 OBJECTIVES/SPECIFIC AIMS: To further explore the role of vWF in the pathogenesis of scleroderma by identifying its location within the tissue of sample biopsies obtained as part of routine diagnosis with the use of immuno-histochemical staining.
Natalia Vasquez Canizares +4 more
doaj +2 more sources
Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation-Related Enzyme, and Molecular Docking Studies. [PDF]
Biomed Res IntDNA methylation is an epigenetic mechanism modulating gene expression without altering the genetic sequence and plays a significant role in skin disorders. Methylation patterns on specific genes can lead to either overexpression or suppression, impacting cellular functions critical to skin health.
Rani A +9 more
europepmc +2 more sources