Results 51 to 60 of about 1,395 (139)

Amicrobial Pustulosis of the Folds Successfully Treated With Apremilast: Report of Two Cases and Review of the Literature

The Journal of Dermatology, Volume 53, Issue 2, Page 339-350, February 2026.
ABSTRACT Amicrobial pustulosis of the folds (APF) is a rare, chronic‐relapsing neutrophilic dermatosis characterized by sterile pustules affecting major and minor skin folds. It predominantly affects women and is frequently associated with autoimmune diseases such as systemic lupus erythematosus, inflammatory bowel disease, and autoimmune thyroiditis ...
Luca Bettolini, Carlo Alberto Maronese, Stefano Bighetti, Giovanni Genovese, Luisa Sarno, Stefano Buffon, Francesca Laura Boggio, Federica Derlino, Angelo Valerio Marzano   +8 more
wiley   +1 more source

Juvenile-onset localized scleroderma activity detection by infrared thermography [PDF]

Rheumatology, 2002
The aim of this study was to define the clinical utility of infrared thermography in disease activity detection in localized scleroderma (LS).We retrospectively reviewed 130 thermal images of 40 children with LS and calculated the sensitivity and specificity of thermography, comparing clinical descriptions of the lesions and contemporary thermographs ...
Martini G., Murray K. J., Howell K. J., Harper J., Atherton D., Woo P., Zulian F., Black C. M.   +7 more
openaire   +4 more sources

Advances in Novel Therapeutic Strategies for Pulmonary Arterial Hypertension

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Pulmonary arterial hypertension (PAH) is a progressive, life‐threatening disease characterized by vascular remodeling, endothelial dysfunction, and chronic inflammation. Despite existing targeted therapies, long‐term outcomes remain poor, underscoring the need for more effective treatment.
Yalei Wang, Jiacheng Wu, Qian Ma, Hao Chen, Erha Lama, Yulu Yang, Jianwu Huang, Changhu Liu, Xiaofei Ni, Zhihua Qiu, Zihua Zhou, Sami Deniz   +11 more
wiley   +1 more source

Identifying Key Questions and Challenges in Microchimerism Biology

Advanced Science, Volume 12, Issue 48, December 29, 2025.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, J. Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
wiley   +1 more source

PRMT1 in Health and Disease: Emerging Perspectives From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 6, Issue 12, December 2025.
Protein arginine methyltransferase 1 (PRMT1) is a pivotal enzyme that catalyzes the asymmetric dimethylation of arginine residues, thereby functioning as a critical epigenetic regulator of diverse biological processes such as gene expression, RNA splicing, and DNA repair.
Yanqun Luo, Ying Gao, Xiaoliang Deng, Lei Wang, Tao Wu   +4 more
wiley   +1 more source

Localized scleroderma in a cohort of juvenile idiopathic arthritis children [PDF]

Pediatric Rheumatology, 2014
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. Localized scleroderma also known as morphea is an inflammatory, fibrosing skin disorder that leads to sclerosis of the dermis and eventually of the underlying tissues.
Giani, Teresa, Paganelli, Valeria, Marrani, Edoardo, Gabriele, Simonini, Pagnini, Ilaria, Marino, Achille, Cimaz, Rolando   +6 more
openaire   +1 more source

Progressive Soft Tissue Swelling in a Pediatric Patient Leading to the Diagnosis of Fibrodysplasia Ossificans Progressiva: A Case Report

Pediatric Dermatology, Volume 42, Issue 6, Page 1252-1254, November/December 2025.
ABSTRACT Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification (HO) and congenital malformation of the great toes. This case describes a 5‐year‐old Caucasian girl who initially presented with painless neck and back swelling as well as severe limitation of movement in the neck and ...
Orhan Yilmaz, Loretta Fiorillo
wiley   +1 more source

3233 Von Willebrand Factor is Localized in the Extravascular tissue of Patients with Juvenile Scleroderma

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: To further explore the role of vWF in the pathogenesis of scleroderma by identifying its location within the tissue of sample biopsies obtained as part of routine diagnosis with the use of immuno-histochemical staining.
Natalia Vasquez Canizares, Morayma Reyes Gil, Dawn M. Wahezi, Beamon Agarwal, Tamar Rubinstein   +4 more
doaj   +1 more source

Disabling pansclerotic morphea of childhood with extracutaneous manifestations

Indian Journal of Dermatology, 2013
Disabling pansclerotic morphea (DPM) of childhood is a rare generalized type of localized scleroderma (LS) that is known to follow an aggressive course with pansclerotic lesions leading to severe joint contractures and consequent immobility. Mortality is
Mahendra M Kura, Saurabh R Jindal
doaj   +1 more source

Narrowing Down Key Players in Autoimmunity via Single‐Cell Multiomics

European Journal of Immunology, Volume 55, Issue 6, June 2025.
This review explores how single‐cell sequencing and multiomics reveal cell states and communication networks involved in autoimmunity. We highlight insights into antigen specificity and autoreactive lymphocytes, uncovering mechanisms like molecular mimicry.
Altea Gjurgjaj, Cecilia Domínguez Conde
wiley   +1 more source