Results 61 to 70 of about 2,722 (180)

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): Architecture [PDF]

, 2014
We describe the architecture of the Patient Centered Outcomes Research Institute (PCORI) funded Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS, http://www.SCILHS.org) clinical data research network, which leverages the $48
Adams, William G, Bernstam, Elmer, Bickel, Jonathan, Ge, Yaorong, Hripcsak, George, Klann, Jeffrey G, Kohane, Isaac S, Mandel, Joshua, Mandl, Kenneth D, Marsolo, Keith, McFadden, Douglas, Murphy, Shawn N, Natter, Marc, Ofili, Elizabeth, Perkins, James, Quarshie, Alexander, Schneeweiss, Sebastian, Showalter, John, Weber, Griffin M, Weiler, Sarah, Zhou, Xiaobo   +20 more
core   +2 more sources

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, Volume 177, Issue 4, Page 736-748, April 2026.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, Volume 6, Issue 1, Page 16-38, March 2026.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

The Videofluorographic Swallowing Study in Rheumatologic Diseases: A Comprehensive Review [PDF]

, 2017
Autoimmune connective tissue diseases are a heterogeneous group of pathologies that affect about 10% of world population with chronic evolution in 20%-80%.
Costanzo, M., Cupido, F., DI PIAZZA, A., Galia, M., Lagalla, R., LO CASTO, A., LO RE, G., Midiri, F., Midiri, M., Picone, D., Salerno, S., Salvaggi, F., Scopelliti, L., Vernuccio, F.   +13 more
core   +3 more sources

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source

A Teenage Guitarist's Swollen Fingers

JEADV Clinical Practice, EarlyView.
Maho Matsuo, Hiroaki Iwata
wiley   +1 more source

Amicrobial Pustulosis of the Folds Successfully Treated With Apremilast: Report of Two Cases and Review of the Literature

The Journal of Dermatology, Volume 53, Issue 2, Page 339-350, February 2026.
ABSTRACT Amicrobial pustulosis of the folds (APF) is a rare, chronic‐relapsing neutrophilic dermatosis characterized by sterile pustules affecting major and minor skin folds. It predominantly affects women and is frequently associated with autoimmune diseases such as systemic lupus erythematosus, inflammatory bowel disease, and autoimmune thyroiditis ...
Luca Bettolini, Carlo Alberto Maronese, Stefano Bighetti, Giovanni Genovese, Luisa Sarno, Stefano Buffon, Francesca Laura Boggio, Federica Derlino, Angelo Valerio Marzano   +8 more
wiley   +1 more source

Association of FCGR3A and FCGR3B haplotypes with rheumatoid arthritis and primary Sjögren's syndrome [POSTER PRESENTATION] [PDF]

, 2005
Background Rheumatoid arthritis (RA) is an autoimmune disease that is thought to arise from a complex interaction between multiple genetic factors and environmental triggers.
Barrett, J.H., Bowman, S.J., Conaghan, P.G., Cooper, D., Emery, P., Green, M., Haroon-Rashid, L., Isaacs, J.D., Lawson, C.A., Mackie, S., Martin, S., Morgan, A.W., Pease, C.T., Quinn, M., Robinson, J.I.   +14 more
core   +2 more sources

Advances in Novel Therapeutic Strategies for Pulmonary Arterial Hypertension

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Pulmonary arterial hypertension (PAH) is a progressive, life‐threatening disease characterized by vascular remodeling, endothelial dysfunction, and chronic inflammation. Despite existing targeted therapies, long‐term outcomes remain poor, underscoring the need for more effective treatment.
Yalei Wang, Jiacheng Wu, Qian Ma, Hao Chen, Erha Lama, Yulu Yang, Jianwu Huang, Changhu Liu, Xiaofei Ni, Zhihua Qiu, Zihua Zhou, Sami Deniz   +11 more
wiley   +1 more source