Results 71 to 80 of about 10,033 (195)

The frequency of pulmonary hypertension in patients with juvenile scleroderma

Biomolecules & Biomedicine, 2015
Juvenile scleroderma (JS) represents a rarely seen group of connective tissue diseases with multiple organ involvement. Cardiac involvement in JSS is well known and, although rare in children, it may be an important cause of mortality and morbidity ...
Amra Adrovic, Funda Oztunc, Kenan Barut, Aida Koka, Refet Gojak, Sezgin Sahin, Tuncalp Demir, Ozgur Kasapcopur   +7 more
doaj   +1 more source

An i2b2-based, generalizable, open source, self-scaling chronic disease registry [PDF]

, 2014
Objective: Registries are a well-established mechanism for obtaining high quality, disease-specific data, but are often highly project-specific in their design, implementation, and policies for data use.
Bousvaros, Athos, Ilowite, Norman T, Inman, Christi J, Mandl, Kenneth D, Marsolo, Keith, McMurry, Andrew J, Natter, Marc D, Ortiz, David M, Quan, Justin, Sandborg, Christy I, Schanberg, Laura E, Wallace, Carol A, Warren, Robert W, Weber, Griffin M   +13 more
core   +1 more source

A Rare Case of Juvenile Systemic Sclerosis: Clinical Challenges and Management

Annals of Rheumatology and Autoimmunity
Scleroderma is “skleros” sclerosing or hardening of the “derma” skin. It includes both systemic and localized scleroderma (LS). Mostly, juvenile LS affects the skin, whereas juvenile systemic sclerosis (SSc) involves multiple organ systems.
Areej Bano, Shalini Verma, Shrish Bhatnagar   +2 more
doaj   +1 more source

Periodontitis and Periodontal Conditions in Systemically Healthy Children and Adolescents

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Objective To answer the PICoS question ‘in systemically healthy children and adolescents (Population), what are the main features of periodontitis, necrotising periodontal diseases (NPD) and other periodontal conditions (periodontal abscesses, endo‐periodontal lesions, traumatic occlusal forces, prosthesis‐ and tooth‐related factors ...
Inbar Eshkol‐Yogev, Nagore Ambrosio, Cheryl Somani, Elena Figuero, Lior Shapira, Janet Davies   +5 more
wiley   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source

Identifying Key Questions and Challenges in Microchimerism Biology

Advanced Science, Volume 12, Issue 48, December 29, 2025.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, J. Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
wiley   +1 more source

Optimal management strategies for paediatric morphea – insights from a case series

Pediatria Polska
Juvenile localized scleroderma, or morphea, is a rare chronic inflammatory disease primarily affecting the skin and subcutaneous tissue. Treatment options for paediatric cases are diverse, with a lack of standardised guidelines.
Kinga Łagosz, Natalia Bień, Justyna Ceryn, Paulina Barsińska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Aleksandra Lesiak   +6 more
doaj   +1 more source

How I explore ... the skin functional involvement in scleroderma [PDF]

, 2013
peer reviewedScleroderma refers to distinct clinical presentations sharing in common a sclerotic process most often clinically obvious on the skin. The involvement possibly affects the skin alone in morphea or in combination with internal lesions in ...
Andre, B., De Roover, C., Delvenne, Philippe, Franchimont, Claudine, Hermanns-Lê, Trinh, PIERARD, Gérald, Renwart, L.   +6 more
core  

PRMT1 in Health and Disease: Emerging Perspectives From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 6, Issue 12, December 2025.
Protein arginine methyltransferase 1 (PRMT1) is a pivotal enzyme that catalyzes the asymmetric dimethylation of arginine residues, thereby functioning as a critical epigenetic regulator of diverse biological processes such as gene expression, RNA splicing, and DNA repair.
Yanqun Luo, Ying Gao, Xiaoliang Deng, Lei Wang, Tao Wu   +4 more
wiley   +1 more source

Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): Architecture [PDF]

, 2014
We describe the architecture of the Patient Centered Outcomes Research Institute (PCORI) funded Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS, http://www.SCILHS.org) clinical data research network, which leverages the $48
Adams, William G, Bernstam, Elmer, Bickel, Jonathan, Ge, Yaorong, Hripcsak, George, Klann, Jeffrey G, Kohane, Isaac S, Mandel, Joshua, Mandl, Kenneth D, Marsolo, Keith, McFadden, Douglas, Murphy, Shawn N, Natter, Marc, Ofili, Elizabeth, Perkins, James, Quarshie, Alexander, Schneeweiss, Sebastian, Showalter, John, Weber, Griffin M, Weiler, Sarah, Zhou, Xiaobo   +20 more
core   +2 more sources