Results 101 to 110 of about 10,476 (135)

Treatment Options for Juvenile-Onset Systemic Lupus Erythematosus

Pediatric Drugs, 2002
Systemic lupus erythematosus (SLE) is an inflammatory chronic disease characterized by the presence of activated helper T-cells that induce a B-cell response, resulting in the secretion of pathogenic autoantibodies and the formation of immune complexes.
Luis, Carreño, Francisco Javier, López-Longo, Carlos Manuel, González, Indalecio, Monteagudo   +3 more
openaire   +2 more sources

Comparison of juvenile and adult onset systemic lupus erythematosus

British Journal of Hospital Medicine, 2012
Systemic lupus erythematosus is a multisystem autoimmune disease of unknown aetiology, described as juvenile systemic lupus erythematosus if the onset is before 16–18 years of age. This review outlines current understanding of juvenile systemic lupus erythematosus and differences between this and adult onset disease.
Tanya, Baqai, Yiannis, Ioannou
openaire   +2 more sources

Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus

Annals of the Rheumatic Diseases, 2014
This study tested the concurrent validity of the systemic lupus erythematosus responder index (SRI) in assessing improvement in juvenile-onset systemic lupus erythematosus (jSLE).The SRI considers changes in the SELENA-SLEDAI, BILAG and a 3-cm visual analogue scale of physician-rated disease activity (PGA) to determine patient improvement.
Mina R, Klein Gitelman MS, Nelson S, Eberhard BA, Higgins G, Singer NG, Onel K, Tucker L, O'Neil KM, Punaro M, Levy DM, Haines K, MARTINI, ALBERTO, Ruperto N, Lovell D, Brunner HI   +15 more
openaire   +4 more sources

Pulmonary hypertension in juvenile-onset systemic lupus erythematosus: a case series

Clinical and Experimental Rheumatology, 2022
Systemic lupus erythematosus (SLE) is a rare multisystem autoimmune disorder with a variable clinical phenotype. Pulmonary hypertension (PHTN) is a recognised (and not uncommonly asymptomatic) complication of the condition with an associated poor prognosis in adults.
Platt, Caroline, Longthorpe, Catherine, Sit, Jacqueline, Marks, Stephen D, Harmer, Matthew, Ciurtin, Coziana, Ramanan, Athimalaipet V, Beresford, Michael W   +7 more
openaire   +3 more sources

Juvenile-onset systemic lupus erythematosus

2013
Paediatric or juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune condition, differing from the adult form in terms of severity, organ manifestations, and a less striking female predominance. The diagnosis relies on the adult-derived American College of Rheumatology SLE classification criteria. Genetic, autoantibody, and host immune
Louise Watson, Michael W. Beresford
openaire   +1 more source

Anti‐C1q Antibodies in Juvenile‐Onset Systemic Lupus Erythematosus

Annals of the New York Academy of Sciences, 2009
The objective of this study was to evaluate the presence of anti‐C1q antibodies Hospital Israelita Albert Einstein Research Institute, São Paulo, Brazil in 67 juvenile systemic lupus erythematosus (JSLE) patients and 26 healthy controls and to assess the association of these antibodies with disease activity, nephritis, and presence of anti‐double ...
A A, Jesus, C A, Silva, M, Carneiro-Sampaio, M, Sheinberg, C L, Mangueira, S K, Marie, B L, Liphaus   +6 more
openaire   +2 more sources

Assessment of Damage in Juvenile-Onset Systemic Lupus Erythematosus: A Multicenter Cohort Study. [PDF]

Arthritis and Rheumatism, 2003
AbstractObjectiveTo investigate the prevalence of cumulative organ damage in patients with juvenile‐onset systemic lupus erythematosus (SLE) and its association with demographic and clinical variables, medication use, and quality of life.MethodsThe occurrence of organ system damage, as measured by the Systemic Lupus International Collaborating Clinics ...
Alberto Martini, Nicolino Ruperto, Angelo Ravelli   +2 more
exaly   +4 more sources

Ocular Manifestations in Children with Juvenile-Onset Systemic Lupus Erythematosus

Seminars in Ophthalmology, 2017
To study the ocular manifestations of juvenile systemic lupus erythematosus (JSLE), including the ocular side-effects of the systemic medications used.A descriptive cross-sectional study on 40 children diagnosed with JSLE was conducted. Ophthalmological and laboratory investigations as well as a calculation of the Systemic Lupus Disease Activity Index ...
Ghada, Gawdat, Dina, El-Fayoumi, Huda, Marzouk, Yomna, Farag   +3 more
openaire   +2 more sources

Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus

Annals of the Rheumatic Diseases, 2009
To investigate differences in clinical signs and symptoms, and in antinuclear antibodies (ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE).Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay
I E A, Hoffman, B R, Lauwerys, F, De Keyser, T W J, Huizinga, D, Isenberg, L, Cebecauer, J, Dehoorne, R, Joos, G, Hendrickx, F, Houssiau, D, Elewaut   +10 more
openaire   +2 more sources

THU0330 Damage in juvenile-onset systemic lupus erythematosus

Annals of the Rheumatic Diseases, 2012
Background Children and adolescents with juvenile-onset systemic lupus erythematosus (jSLE) face considerable morbidity due to sequelae of disease activity, comorbidities and adverse effects of treatment. In order to improve the management of these patients, it is essential to better understand the risk factors associated with the development of ...
P. Costa Reis, J. Isgro, S. Nativ, C. Yildirim-Toruner, A. Starr, L. Imundo, A. Eichenfield   +6 more
openaire   +1 more source