Results 121 to 130 of about 10,648,609 (305)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

University Symphonic Band, October 12, 1997

open access: yes, 2016
Recorded during a live performance at Miller Auditorium, Western Michigan University, Kalamazoo, Michigan, October 12, 1997, 3:00 p.m., the 36th concert of the School of Music's 1997-1998 season.University Symphonic Band, Robert L.
Western Michigan University. Symphonic Band
core  

Design of K-Band Substrate Integrated Waveguide Band-Pass Filter with High Rejection

open access: yesJournal of Microwaves, Optoelectronics and Electromagnetic Applications
This article presents the design of K-band Substrate Integrated Waveguide (SIW) Band-pass filter with high rejection, by using the topology with iris and the SIW resonators.
Ahmed Rhbanou   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Chemical Pressure‐Induced Unconventional Band Convergence Leads to High Thermoelectric Performance in SnTe

open access: yesAdvanced Science
Band convergence is considered a net benefit to thermoelectric performance as it decouples the density of states effective mass (md∗) and carrier mobility (µ) by increasing valley degeneracy.
Hongwei Ming   +2 more
doaj   +1 more source

A new stellar library in the K band

open access: yes, 2005
Stellar population synthesis models are crucial for the understanding of the large amount of data which is being gathered for galaxies at low and high redshift, and provide the only way to compare the "real world" with the theoretical framework. The best models require extensive empirical stellar spectral libraries, which at present are starting to be ...
Mármol Queraltó, E.   +7 more
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy