The H19/miR‐760/BST2 regulatory axis sustains breast cancer tumorigenesis and metastasis
The FEBS Journal, EarlyView.H19 and BST2 promote breast cancer aggressiveness through their reciprocal coregulation by miR‐760. Since both transcripts are targeted by miR‐760, overexpression of one sequesters the microRNA and relieves repression of the other: H19 raises BST2 levels, and BST2 raises H19 levels.
Kekely Klouyovo +8 more
wiley +1 more source
Macrophage restriction in <i>Drosophila</i> wounds and tumors via a matrix degradation-moderating protease inhibitor. [PDF]
Sci AdvSakai Y +5 more
europepmc +1 more source
Dimerization of human PARP15 is required for NAD+ binding and automodification
The FEBS Journal, EarlyView.This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen +9 more
wiley +1 more source
RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms
The FEBS Journal, EarlyView.RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon +4 more
wiley +1 more source
Ex Vivo Immune Response of Casein-Sensitized Lymphocytes to Bovine Milk Protein Composite Genotypes: Beyond the β-Casein A1/A2 Paradigm. [PDF]
NutrientsMarkiewicz LH +7 more
europepmc +1 more source
Gerodontology, EarlyView.ABSTRACT Introduction To evaluate the efficacy of dental varnishes/gels in the prevention/management of dental caries in older adults. Methods Cochrane, PubMed, Web of Science and EMBASE were searched through March 2024 for randomized controlled trials (RCT) including patients aged ≥ 60 years (or average age ≥ 60 years) utilizing varnish or gel ...
Theresa Cleary +3 more
wiley +1 more source
Peptidome and Metabolome Profiling of Fermented Milk Products Reveal Accumulation of Bioactive Compounds During Cold Storage. [PDF]
Curr Issues Mol BiolSheludchenko MS +5 more
europepmc +1 more source
A Systematic Review Evaluating Methods for Diagnosis, Treatment and Prevention of Dental Erosions
International Journal of Dental Hygiene, EarlyView.ABSTRACT Aim The aim of this systematic review was to investigate the quality of evidence for methods used to diagnose, restore and prevent dental erosions, by evaluating and summarising clinical controlled studies and in situ studies covering this field.
Maria Skalsky Jarkander +5 more
wiley +1 more source
The Complex World of Toothpaste Diversity, Meeting Patient Clinical Needs. An Umbrella Review
International Journal of Dental Hygiene, EarlyView.ABSTRACT Background Amidst numerous recent advancements in toothpaste formulations and active ingredients, some clinicians may believe all toothpastes are similar despite differences in their active ingredients and corresponding clinical application.
Jeanie Suvan, Crystal Marruganti
wiley +1 more source