Results 101 to 110 of about 14,634,982 (301)

Functional level assessment of individuals with transtibial limb loss: Evaluation in the clinical setting versus objective community ambulatory activity

open access: yesJournal of Rehabilitation and Assistive Technologies Engineering, 2016
The functional level (K level) of prosthetic users is used to choose appropriate prosthetic components, but ratings may highly subjective. A more objective and robust method to determine K level may be appealing.
Michael S Orendurff   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Achieving ultra low k dielectric constant for nanoelectronics interconnect systems

open access: yes, 2022
S.298-301Air gaps are a promising alternative to porous low-k dielectrics to achieve ultra low k-values in Cu damascene interconnects. Two approaches of air gap formation using wet etch back of sacrificial PECVD SiO2 dielectrics were evaluated concerning
Schulze, K., Schulz, S.E.
core   +1 more source

Direct and Inverse Approximation Theorems for Baskakov Operators with the Jacobi-Type Weight

open access: yesAbstract and Applied Analysis, 2011
We introduce a new norm and a new K-functional Kφλ(f;t)w,λ. Using this K-functional, direct and inverse approximation theorems for the Baskakov operators with the Jacobi-type weight are obtained in this paper.
Guo Feng
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A generalized version of Holmstedt\u27s formula for the K-functional [PDF]

open access: yes
Let $(A_0, A_1)$ be a compatible couple of quasi-normed spaces, and let $Φ_0$ and $Φ_1$ be two general parameters of $K$-interpolation method. We compute $K$-functional for the couple $((A_0,A_1)_{Φ_0}, (A_0, A_1)_{Φ_1})$ in terms of $K$-functional for ...
Fiorenza, Alberto   +2 more
core   +1 more source

Functional activity of H-K-ATPase in individual cells of OMCD: localization and effect of K+ depletion

open access: yes, 1996
Recent studies have indicated the presence of hydrogen-potassium-adenosinetriphosphatase (H-K-ATPase) in the collecting duct. We examined the localization of functional H-K-ATPase activity in individual cells of the outer and inner stripes of outer ...
F. Marumo, M. Kuwahara, W. J. Fu
core   +1 more source

Unique Regulation of Na-K-ATPase during Growth and Maturation of Intestinal Epithelial Cells

open access: yesCells, 2019
Na-K-ATPase on the basolateral membrane provides the favorable transcellular Na gradient for the proper functioning of Na-dependent nutrient co-transporters on the brush border membrane (BBM) of enterocytes.
Niraj Nepal, Subha Arthur, Uma Sundaram
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

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