Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. [PDF]
The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs.
Stephanie Barth +68 more
core +2 more sources
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
zhypan/Functional-Annotation-of-Pig: Functional-Annotation-of-Pig
Zhangyuan Pan#, Yuelin Yao#, Hongwei Yin, Zexi Cai, Ying Wang, Lijing Bai, Colin Kern, Michelle Halstead, Kelly Chanthavixay, Nares Trakooljul, Klaus Wimmers, Goutam Sahana, Guosheng Su, Mogens Sandø Lund, Merete Fredholm, Peter Karlskov-Mortensen ...
pan
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
K-State First CAT Community Program Learning Assistant Guide 2014-2015 [PDF]
CAT CommunitiesA guide for Learning Assistants (LAs) in Connecting Across Topics (CAT) Communities. Provides an overview of all K-State First programs, as well as specific guidelines and suggestions for in-class activities, co-curricular events, and how ...
Kansas State University, K-State First
core
K+ Block Is the Mechanism of Functional Asymmetry in Bacterial Na(v) Channels. [PDF]
Crystal structures of several bacterial Na(v) channels have been recently published and molecular dynamics simulations of ion permeation through these channels are consistent with many electrophysiological properties of eukaryotic channels.
Van Ngo +4 more
doaj +1 more source
A characterization of weighted peetre K-functionals
Let \(X=L_ p[a,b]\) (1\(\leq p\leq \infty)\) and w a ``weight'' (a continuous and locally positive function in [a,b]). Let \(W^ k_ p(w)\) (k\(\in N)\) be the set of all functions which are locally absolutely continuous together with \(g'...g^{(k-1)}\) and \(\| w^ kg^{(k)}\|_ ...
openaire +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
K-State First: A Proposal to Create a First-Year Program at Kansas State University [PDF]
K-State First, University's First Year Experience ProgramA proposal to start a first-year student experience program at Kansas State University. The report provides an outline of recommendations for the implementation of the program, research regarding ...
Kansas State University, K-State First
core

