Results 71 to 80 of about 1,902,060 (282)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Focused ultrasound-mediated temozolomide delivery into intact blood–brain barrier tissue improves survival in patient-derived xenograft model of glioblastoma

open access: yesFluids and Barriers of the CNS
Background Glioblastoma (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by rapid proliferation and invasive infiltration into normal brain tissue. Despite maximal resection and temozolomide (TMZ) chemotherapy, over
Jaewoo Shin   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Cuttlefish-Bone-Derived Hybrid Composite Scaffolds for Bone Tissue Engineering

open access: yesNanomaterials
Current investigations into the fabrication of innovative biomaterials that stimulate cartilage development result from increasing interest due to emerging bone defects.
Vignesh Raj Sivaperumal   +7 more
doaj   +1 more source

On the general K-interpolation method for the sum and the intersection

open access: yesJournal of Inequalities and Applications, 2016
Let ( A 0 , A 1 ) $(A_{0}, A_{1})$ be a compatible couple of normed spaces. We study the interrelation of the general K-interpolation spaces of the couple ( A 0 + A 1 , A 0 ∩ A 1 ) $(A_{0}+A_{1}, A_{0} \cap A_{1})$ with those of the couples ( A 0 , A 1 )
Irshaad Ahmed, Muhammad Awais
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Measuring overall functional diversity by aggregating its multiple facets: Functional richness, biomass evenness, trait evenness and dispersion

open access: yesMethods in Ecology and Evolution
Human activities induce environmental changes, which can affect individuals' traits thereby leading to changes in functional diversity and finally in ecosystem functioning.
Laurie Anne Wojcik   +3 more
doaj   +1 more source

Generalized Jensen functional equation on restricted domain

open access: yesAnnals of the West University of Timisoara: Mathematics and Computer Science, 2014
We prove the Hyers-Ulam stability on restricted domains of generalized Jensen functional ...
Chahbi Abdellatif   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Interpolation of bilinear operators between Banach function spaces

open access: yes, 1999
We study bilinear operators between couples of Banach function spaces with the second coordinate $L_\infty$-space. We show an estimate in terms of the $K$-functional.
Mastylo, M., Staszak, D.
core  

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