Results 131 to 140 of about 151,957 (275)

Vitamin K2 inhibits PGE2-mediated osteoblast ferroptosis by upregulation of CBR1 via the Nrf2/Keap1 pathway

Communications Biology
Osteoporosis is increasingly attracting attention. Studies have indicated a correlation between vitamin K2 levels and bone mass, but the specific mechanisms remain unclear. Therefore, this study aims to further elucidate the specific molecular mechanisms
Lin Tao, Hongyang Li, Jinpeng Wang, Qichang Liu, Wenhai Cao, Yue Zhu   +5 more
doaj   +1 more source

The D(-k2)-triple {1,k2+1,k2+4} with k prime

, 2011
Let n be a nonzero integer. A set of m distinct positive integers is called a D(n)-m-tuple if the product of any two of them increased by n is a perfect square. Let k be a prime number.
Alan Filipin, Fujita, Yasutsugu, Yasutsugu Fujita, Filipin, Alan   +3 more
core   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Synergistic Stabilization of Potassium Metal Anodes Through Orange‐Peel Elimination and Robust Solid–Electrolyte Interphase Formation

Advanced Science, EarlyView.
Synergistic control of surface uniformity and solid–electrolyte interphase robustness regulates potassium deposition, suppressing dendritic growth and enabling uniform, dense potassium plating. This combined strategy promotes stable interfacial chemistry and homogeneous electric‐field distribution, leading to enhanced reversibility and long‐term ...
Pan He, Yupei Han, Yundong Zhou, Ruhan He, Rui Xu, Yunlong Zhao, Junjun Wang, Wanjun Ren, Matthew Hopper, Qinyou An, Denys Makarov, Ian S. Gilmore, Liqiang Mai, Yang Xu   +13 more
wiley   +1 more source

Variationer i beläggning i tid och rum för tre tåglinjer norr om Mälaren

, 2017
Syftet med denna studie är att redovisa beläggningsvariationer i tid och rum för att bedöma om det finns potential för att omfördela vardagsresor från de högst belagda tiderna och delsträckorna till mindre belagda, utan respektive med förändrad ...
Jansson, Kjell, Pyddoke, Roger
core  

Robust Amorphous MOF‐Based Aerogels Digital Biosensor for Sensitive Detection of Organophosphate Pesticides

Advanced Science, EarlyView.
We report a robust aerogel digital biosensor by integrating an enzyme‐mediated amorphous MOF within an aerogel matrix for on‐site pesticide detection. The enzyme‐mediated assembly strategy enables in situ tailoring of MOF into a porous amorphous structure, achieving both high stability and activity.
Changshun Su, Xiangyu Zhai, Houru Li, Yijie Wang, Hongxia Li, Yueyao Jiang, Geyu Lu, Xu Yan   +7 more
wiley   +1 more source

Realtidskartor i kollektivtrafiken : What you see is where you get

, 2020
Inom ramen för projektet What you see is where you get har upplevda och faktiska nyttor med en så kallad realtidskarta för kollektivtrafik studerats.
Dahlman, Joakim, Stave, Christina, Hjort, Mattias, Lindström, Anders, Lidestam, Björn   +4 more
core  

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Dynamic bus lanes in Sweden – a pre-study : PROVDYK – Final report

, 2015
Dedicated bus lanes and bus streets have, in recent years, become common measures for prioritisation of public transport. By ensuring free path along routes, they increase average speed and travel time reliability of buses.
Smith, Göran, Häll, Carl-Henrik, Olstam, Johan, Anund, Anna, Habibovic, Azra   +4 more
core  

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source