Results 1 to 10 of about 6,721 (196)

Evaluation of the Effects of the Quaternary Ammonium Silane K21 on Zebrafish Viability, Toxicity, Growth, and Development [PDF]

Biomedicines
Background: The FDA-cleared antimicrobial quaternary ammonium silane K21 is recognized for its antimicrobial properties. This study explored potential applications of the K21 molecule in human health protection, disease prevention, and treatment using ...
Clifton Carey, Surendra Rajpurohit, Ashwin Ajith   +2 more
exaly   +7 more sources

Antimicrobial FiteBac® K21 promotes antimicrobial Potency and wound healing

Heliyon, 2023
Objectives: Successful root canal therapy is dependent on the efficacy of complete instrumentation and adequate use of chemical irrigant to eliminate the biofilm from dentin surface.
K -K Mak, Muhammad Sharjeel Ilyas, Umer Daood   +2 more
exaly   +6 more sources

Antibacterial and antibiofilm efficacy of k21-E in root canal disinfection

Dental Materials, 2021
The aim of the current project was to study the antimicrobial efficacy of a newly developed irrigant, k21/E against E. faecalis biofilm.Root canals were instrumented and randomly divided into the following groups: irrigation with saline, 6% NaOCl (sodium hypochlorite), 6% NaOCl+2% CHX (Chlorhexidine), 2% CHX, 0.5% k21/E (k21 - quaternary ammonium ...
Umer Daood, K -K Mak
exaly   +7 more sources

Quaternary ammonium silane (k21) based intracanal medicament triggers biofilm destruction [PDF]

BMC Oral Health, 2021
Background Compare antimicrobial efficacy of a quarternary ammonium silane (QAS)/k21 as an intracanal medicament against E. faecalis and C. albicans biofilms formed on root dentin. Methodology Dentin blocks were sterilized and E. faecalis and C. albicans
Amr Fawzy, Umer Daood, Fabian Davamani   +2 more
exaly   +4 more sources

K21 Compound, a Potent Antifungal Agent: Implications for the Treatment of Fluconazole-Resistant HIV-Associated Candida Species [PDF]

Frontiers in Microbiology, 2019
Background/Objectives: With mucocutaneous candidiasis being highly prevalent in HIV patients, the emergence of fluconazole-resistant Candida species forms a major challenge in treating and eradicating these infections.
Cathy N. John, Pedro M. D. S. Abrantes, Bhupesh K. Prusty, Dharam V. Ablashi, Charlene W. J. Africa   +4 more
doaj   +7 more sources

From an Antimicrobial Agent to a constituent of 3D Printed Heterogenous Scaffolds Stimulating Bone Characteristics: An In-vitro and Animal model evaluation [PDF]

Regenerative Therapy
This paper describes a promising candidate molecule, investigates the pattern of scaffold composition which arises and assesses the effect of the agent on its mechanical properties.
Shahad Ahmed Daood, Martha Then Xin Yi, Nicole Wen Ce Mun, Sharjeel Ilyas, Lee Yin Shien, Oh Jia En, Syed Saad Bin Qasim, Yichen Dai, Galvinderjeet Kaur Grewal, Ng Mei Liit, Gopu Sriram, Malikarjuna Rao Pichika, Kit-Kay Mak, Ranjeet Ajit Bapat, Zeeshan Sheikh, Umer Daood   +15 more
doaj   +2 more sources

Semi-Mechanistic Modeling of S-531011, a Humanized Anti-CCR8 Monoclonal Antibody, for Prediction of CCR8 Receptor Occupancy in Human Tumor Tissues. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Semi‐mechanistic modeling approaches could be useful for optimal dose selection, and one of the approaches is pharmacokinetic (PK)/receptor occupancy (RO) model for monoclonal antibodies. This study aimed to develop a semi‐mechanistic PK/RO model of S‐531011, a humanized monoclonal antibody against human CCR8 and under development for the ...
Yamaguchi D, Nogami W, Sonoda Y, Morihara H, Katsube T.   +4 more
europepmc   +2 more sources

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD-L1 Transcription. [PDF]

Adv Sci (Weinh)
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Xue H, Jie X, Liu Z, Fang R, Wu S, Dong X, Xu S.   +6 more
europepmc   +2 more sources

Drug-induced metabolic remodeling promotes antimicrobial activity in macrophages and extends longevity in vivo [PDF]

Life Science Alliance
A potent antimicrobial promotes mitochondrial fission and mitophagy, boosting the effectiveness of macrophages to defend against bacterial infection and promoting lifespan extension in C. elegans . Multiple immune mechanisms must be coordinated to defend
Claudia Hollmann, Eun Chan Park, Zheng Liu, Faye Nourollahi, Emīls Edgars Bašēns, Jonathan Dietz, Trushnal S Waghmare, Mehul Vora, Georgy Nikolayshvili, Nanci S Kane, Tongbin Li, Fabian Imdahl, Kay F Macleod, Zaiga Nora-Krukle, Mohamed M Elashiry, Christopher Rongo, Bhupesh K Prusty   +16 more
doaj   +2 more sources

Reestablishment of RPN Evaluation Method in FMEA Procedure for K21 [PDF]

Journal of the Korean Society for Quality Management, 2012
Purpose: To ensure good quality munitions, we require quantitative risk management and optimal risk management of system characteristics. Methods: Failure mode and effects analysis (FMEA) is a widely used technique to assess or to improve reliability of products at early stage of design and development. Traditionally, the prioritization of failures for
Chang-Hee Lee, Kyung-Woo Yang, Sang-Bu Kim   +2 more
exaly   +2 more sources