K562细胞 - Open Access .click

Results 21 to 30 of about 193 (134)

, 1999
为进一步证实菠萝蛋白酶对肿瘤细胞的诱导分化作用，采用形态观察计数、血红蛋白定量测定、发光法测定细胞吞噬能力和Ｎｏｒｔｈｅｒｎ原位杂交法观察和检测了菠萝蛋白酶诱导Ｋ５６２细胞分化及其ｐ５３基因表达变化．结果显示，菠萝蛋白酶可诱导Ｋ５６２细胞向红系和粒／巨噬系两个方向分化；在菠萝蛋白酶作用下，ｐ５３基因于给药后８ｈ转录表达增强，２４ｈ达高峰，此后又下降，其时相变化先于分化发生．这些结果提示ｐ５３基因在Ｂｒｏｍｅｌａｉｎ诱导Ｋ５６２细胞分化过程中可能起启动分化的重要作用 ...
张铮 +4 more
core

Use of a Cytobrush for Sampling the Ear Canal of Dogs With Otitis Externa

Veterinary Dermatology, Volume 37, Issue 2, Page 227-235, April 2026.
Cytological examination of the ear canal is essential for evaluating dogs with otitis externa (OE). The conventional sampling method uses a swab. However, the cytobrush (gynaecological cervical brush), already used for cytological collection from other anatomical sites, has not been adequately investigated for this purpose in dogs with OE.
Nicoly Radaeli Atanasio +3 more
wiley +1 more source

Study on the abnormal expression of the transcription factor FoxO3a and its mechanism in chronic myelocytic leukemia [PDF]

, 2011
背景：慢性粒细胞白血病(ChronicMyelocyticLeukemia，CML)是一种致命性的恶性造血干细胞疾病，发生源于人9号和22号染色体的易位，导致费城染色体t(9;22)(q34;q11)和融合蛋白P210BCR/ABL的形成。P210BCR/ABL显示异常增强的酪氨酸激酶活性，过度激活下游Ras、PI3K/Akt等信号通路导致肿瘤的发生。FoxO蛋白家族作为转录因子通过调节细胞内多种重要基因的表达，而介导细胞周期、DNA损伤修复、凋亡、氧化应激、细胞分化代谢等细胞生理过程 ...
杜艳
core

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source

The Transcription Factor FoxO3a Inhibits Proliferation, Promotes Apotosis and Differerntiation of K562 Cell [PDF]

, 2012
慢性粒细胞白血病一旦发展至急变期，预后极差，目前的各种治疗方法均不能有效控制其病情进展，多在数月内死亡，因而加强对急变期的研究具有很重要的科学及临床意义。急变发生机制中，BCR-ABL融合基因大量表达、继发性多种基因突变以及凋亡受阻、耐药等机制逐渐已经被阐明，但有关分化障碍的机制研究很少且不明确[1;2]。分化障碍往往与信号通路中的转录因子异常有关，FoxO3a是FOX转录因子家族是一个重要成员，是BCR-ABL/PI3K/AKT信号通路的下游因子，而其在慢粒急变中的功能失活 ...
李楠楠
core

Hybrid Probiotic Hydrogel With Curcumin‐Loaded MnO2 Nanoparticles Enhances Diabetic Wound Healing Through Multimodal Microenvironmental Regulation

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source

Multiple pregnancy with complete hydatidiform mole and coexisting normal fetus: systematic review and meta‐analysis of clinical outcomes from non‐randomized studies

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 272-282, March 2026.
ABSTRACT Objective Complete hydatidiform mole and coexisting normal fetus (CHMCF) is a rare condition for which there is significant heterogeneity in diagnosis, counseling and management of complications. The objective of this study was to summarize the prevalence of clinical outcomes in reported cases of CHMCF.
N. Salmeri +8 more
wiley +1 more source

Research on the effect of DHA on glucose metabolism in human lung cancer cells and its anti-tumor mechanism [PDF]

, 2015
研究背景及目的：肺癌是人类最常见的恶性肿瘤之一，尽管近年来治疗取得了很大进展，治疗效果仍然较差。癌细胞具有偏向通过糖酵解方式来进行糖代谢获得能量的代谢特征使得肿瘤细胞能够比正常细胞具有更强的葡萄糖代谢能力，为肿瘤细胞的快速增殖与生长提供了能量来源，也使其具备更强的凋亡抵抗能力。天然产物凭借其来源广泛、类型多样、不良反应小，具有开发为化疗药物增效减毒辅助药物的潜力等特点备受关注。双氢青蒿素是青蒿叶中分离的有效抗疟成分，体内代谢活性产物为双氢青蒿素。药物学研究证实青蒿素类药物具有抗疟、抗血吸虫 ...
米彦军
core

Ultrasound features in early pregnancy for predicting abnormal karyotype in first‐trimester miscarriage

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 376-384, March 2026.
ABSTRACT Objective To investigate whether combining abnormal morphological features observed on ultrasound in live pregnancies that ended in a first‐trimester miscarriage can predict an abnormal karyotype. Methods This retrospective observational cohort study was conducted at the early‐pregnancy assessment unit at University College London Hospital ...
T. Setty +5 more
wiley +1 more source

慢性粒细胞白血病
白血病
medicine general

姜黄素
脐血