Results 31 to 40 of about 192 (134)
Veterinary Dermatology, EarlyView.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source
Characterization of Dll4 Monoclonal Antibody which can block the Dll4-Notch signaling pathway [PDF]
, 2017 1917年，ThomasHuntMorgan在果蝇中首次发现Notch基因，1980年Notch基因首次被克隆出来。Notch信号通路是一条保守而重要的信号转导通路，它对细胞命运的影响非常大，通过相邻细胞之间的相互作用调节细胞分化、增殖和凋亡，在许多至关重要的生理、病理过程中都起着重要作用。Notch信号通路由Notch受体、Notch配体（DSL蛋白）、CSL（CBF-1，Suppressorofhairless，Lag的合称）DNA结合蛋白、其他的效应物和Notch的调节分子等组成 ...
徐哲妮
core
Veterinary Dermatology, Volume 37, Issue 1, Page 103-110, February 2026.Background: Otitis externa with secondary bacterial or yeast infection is a common problem in small animal practice. Cold physical plasma (CPP) has been reported to have antimicrobial activity in vitro. Results: Ears treated additionally with CPP showed lower otic scores after 21 days compared to nontreated ears, although this difference was not ...
Ralf S. Mueller, Cosima Bouassiba
wiley +1 more source
Reprogramming of histone methylation modification during the monocyte-macrophage differentiation [PDF]
, 2016 单核-巨噬细胞分化过程受到多方面因素的影响，不同分化诱导物激活不同信号通路引起的不同转录因子的改变进而导致单核-巨噬细胞的分化是目前研究巨噬细胞分化机制的基本思路。巨噬细胞分化过程中如何受动态建立的表观遗传学修饰、调控转录因子的动态变化机制仍未明了。本研究使用ChIP-on-chip发现了正性组蛋白甲基化修饰H3K4me3以及负性修饰H3K27me3在巨噬-细胞分化相关的装录因子启动子上均有修饰，如HOXAs和FOXOs等。HOXAs基因的表达被快速抑制与单核-巨噬细胞分化进程密切相关 ...
郑启凡
core
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu +13 more
wiley +1 more source
Matrine Inhibits Proliferation and Induces Apoptosis via Bid-mediated mitochondrial pathway in esophageal cancer cells [PDF]
, 2012 食管癌是一种高发的致命性恶性肿瘤，这些年来在美国及其他发达国家的迅速发展。在2011年确诊的病例超过167200例，在中国发病率也是居高不下。在食管癌的治疗手段中以手术和放化疗为主，但是由于食管癌对放化疗有很高的耐受性，而手术治疗又增加了患者的痛苦，所以我们亟待找到一种新的有效的药物治疗食管癌的方法。 苦参为中国传统中药，系豆科植物苦参的干燥根，是以苦参次碱15酮为基本结构的化合物，主要来源于苦参根及苦豆子的提取物。苦参提取物中含有多种生物碱，最主要成分为氧化苦参碱和苦参碱。苦参碱对人体发挥很多药理作用，
王趫
core
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley +1 more source
姜黄素衍生物C1209抑制慢性粒细胞白血病细胞增殖与阻断Hsp90伴侣功能的关系 [PDF]
, 2018 目的研究姜黄素衍生物C1209抑制慢性粒细胞白血病细胞增殖与阻断Hsp90伴侣功能的关系。方法采用荧光光谱法,研究不同浓度C1209与Hsp90、其N端片段（NHsp90）、M端片段（MHsp90）、C端片段（CHsp90）的相互作用,以及不同温度（293 K、303 K、310 K）下,C1209与Hsp90的相互作用;实验选取280 nm为激发波长,290510 nm的波长范围内进行荧光光谱扫描。采用孔雀绿磷钼酸铵-无机磷检测法,研究C1209对Hsp90-ATPase活性的抑制。四甲基偶氮唑蓝 ...
周义湘 +3 more
core
Boron Difluoride Chelated Aminoanthraquinone Photosensitizer for Type I Photodynamic Therapy
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Type I photosensitizers capable of generating cytotoxic reactive oxygen species (ROS), with reduced oxygen dependence under photoirradiation, are regarded as a promising phototherapeutic approach for hypoxic solid tumors. Herein, based on the electron donor of 9‐phenyl‐carbazole (Cz) and the electron acceptor of anthraquinone (AQ ...
Tian Zhang +8 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2018 目的研究姜黄素诱导自噬对K562细胞增殖的影响。方法采用1、5、10、20和40μM/L姜黄素及自噬抑制剂3-MA作用于K562细胞24h,采用MTT实验观察K562细胞增殖变化情况,随后采用Western-blot检测自噬标志蛋白LC3-II/LC3-I变化水平;同时Western blot分析p53,p21和p27表达变化。结果姜黄素能以时间、剂量依赖性方式抑制K562细胞增殖,与3-MA对照组相比,LC3-II/LC3-I比值显著上升,姜黄素诱导K562细胞周期停滞,上调p53 ...
于波海, 于鑫, 王鑫, 滕旭
doaj