Results 201 to 210 of about 79,611 (233)
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Stereoselective Accumulation of Propranolol Enantiomers in K562 and K562/ADR Cells
Chirality, 2013ABSTRACTThe stereoselective uptake of propranolol enantiomers was investigated by using the K562 and K562 adriamycin‐resistant cell line (K562/ADR) as a model. An enantioselective RP‐HPLC method was applied to determine the accumulation of propranolol (PPL) stereoisomers in K562 and K562/ADR cells.
Xiao-Li, Zheng +3 more
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Glycophorins of human erythroleukemic K562 cells
Archives of Biochemistry and Biophysics, 1987Glycophorins related to alpha glycophorin, of the human erythrocyte membrane, were isolated from human erythroleukemic K562 cells. The glycophorins were purified using sodium dodecyl sulfate (SDS)/trichloroacetic acid fractionation and Folch and hot phenol extractions. 0.1-0.2 micrograms was obtained/10(8) cells, or approximately a 15% yield.
R E, Silver +2 more
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K562—A human erythroleukemic cell line
International Journal of Cancer, 1979AbstractWe have studied the surface membrane properties of the human leukemic cell line K562 which previously has been reported to represent an early stage of granulocyte maturation. The surface glycoprotein pattern of the K562 cells obtained after galactose oxidase‐NaB[3H]4 labelling and slab gel electrophoresis shows striking similarities with that ...
L C, Andersson +2 more
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Anti-cancer effects of deguelin on human leukemia K562 and K562/ADM cells In Vitro
Journal of Huazhong University of Science and Technology, 2007In order to investigate the anti-cancer effects of deguelin and on K562 and K562/ADM cells in vitro and the underlying molecular mechanism and compare the cytotoxicity of deguelin on K562, K562/ADM cells and human peripheral blood mononuclear cells (PBMCs). The effects of deguelin on cell proliferation were assessed by MTT assay.
Qiuling, Wu +3 more
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Mechanism of Simvastatin-Induced K562 Cell Apoptosis
Pharmacology, 2009Statins are being widely used for the therapy and prevention of several types of tumors, including human chronic myelogenous leukemia, but the underlying molecular mechanisms still remain unknown. Therefore, inhibition of cell proliferation, apoptosis and involved molecules were investigated in K562 cells after incubation with simvastatin.The results ...
Yong-Chang, Yang +8 more
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Variation amongst K562 cell cultures.
Experimental hematology, 1983K562 cell cultures were obtained from three laboratories (A, B and C) outside our institution, and were designated according to source as K562A, K562B or K562C. The cultures obtained were constitutive or "wild type" K562 cell cultures, not cloned sublines.
I W, Dimery +6 more
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BCL11A represses HBG transcription in K562 cells
Blood Cells, Molecules, and Diseases, 2009BCL11A on chromosome 2p16 was recently shown to be a major quantitative trait locus for Hb F level and F-cell number in several populations with or without beta-hemoglobinopathy. We now show that BCL11A isoforms are expressed in K562 cells. Butyrate induction of HBG globin production in K562 is associated with reduced BCL11A.
Zhiyi, Chen +3 more
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Canadian Journal of Physiology and Pharmacology, 2004
Natural products from plants such as flavonoids are potential drugs to overcome multidrug resistance (MDR) in cancer treatments. However, their modes of action are still unclear. In this study, the effects of quercetin on mitochondrial membrane potential (ΔΨm) change as well as quercetin's ability to induce apoptosis and inhibit Pgp-mediated efflux of
S, Kothan +5 more
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Natural products from plants such as flavonoids are potential drugs to overcome multidrug resistance (MDR) in cancer treatments. However, their modes of action are still unclear. In this study, the effects of quercetin on mitochondrial membrane potential (ΔΨm) change as well as quercetin's ability to induce apoptosis and inhibit Pgp-mediated efflux of
S, Kothan +5 more
openaire +2 more sources