Results 1 to 10 of about 4,454,791 (262)

Characterization of a particulate pathway for copper in K562 cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1994
More than half of the 67Cu recovered from K562 cells following a brief incubation with 67Cu-ceruloplasmin was recovered in particulate fractions of the cell. The fractions in Percoll had densities that ranged between 1.040 and 1.060 g/dl. In as early as 5 min, two fractions, densities of 1.051 and 1.056, respectively, were discernible.
L A, Davidson, S L, McOrmond, E D, Harris   +2 more
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Glycosphingolipids of K562 cells: A chemical and immunological analysis

International Journal of Cancer, 1981
AbstractThe K562 cell line, which was established from a patient with chronic myeloid leukemia in blast crisis, was thought to be myeloid, but recent data indicate that it is an undifferentiated erythroid cell line. We have found that the glycosphingolipid content of these cells differs considerably from that of mature erythrocytes ...
A, Suzuki, R A, Karol, S K, Kundu, D M, Marcus   +3 more
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BCL11A represses HBG transcription in K562 cells

Blood Cells, Molecules, and Diseases, 2009
BCL11A on chromosome 2p16 was recently shown to be a major quantitative trait locus for Hb F level and F-cell number in several populations with or without beta-hemoglobinopathy. We now show that BCL11A isoforms are expressed in K562 cells. Butyrate induction of HBG globin production in K562 is associated with reduced BCL11A.
Zhiyi, Chen, Hong-yuan, Luo, Martin H, Steinberg, David H K, Chui   +3 more
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Anti-cancer effects of deguelin on human leukemia K562 and K562/ADM cells In Vitro

Journal of Huazhong University of Science and Technology, 2007
In order to investigate the anti-cancer effects of deguelin and on K562 and K562/ADM cells in vitro and the underlying molecular mechanism and compare the cytotoxicity of deguelin on K562, K562/ADM cells and human peripheral blood mononuclear cells (PBMCs). The effects of deguelin on cell proliferation were assessed by MTT assay.
Qiuling, Wu, Yan, Chen, Hongli, Liu, Jing, He   +3 more
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Expression profile of Notch‐related genes in multidrug resistant K562/A02 cells compared with parental K562 cells

International Journal of Laboratory Hematology, 2010
SummaryDrug resistance is the major setback of acute myeloid leukemia (AML) therapy. Notch proteins have demonstrated functional regulation in cell proliferation, differentiation, and apoptosis and thus may affect drug resistance. Our study aimed to identify the Notch‐related gene profile in drug‐resistant AML cells and provide potential strategies for
S, Yan, D, Ma, M, Ji, D, Guo, J, Dai, P, Zhao, C, Ji   +6 more
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Geldanamycin Induces Cell Cycle Arrest in K562 Erythroleukemic Cells

IUBMB Life, 1999
AbstractGeldanamycin (GA), a benzoquinone ansamycin, is one of the specific inhibitors of 90‐kDa heat shock protein and induces growth inhibition and apoptosis in certain cancer cell lines. We have investigated the mechanism of GA‐induced growth inhibition in K562 erythroleukemic cells.
H R, Kim, C H, Lee, Y H, Choi, H S, Kang, H D, Kim   +4 more
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K562 cells: a source for embryonic globin chains

Journal of Chromatography B: Biomedical Sciences and Applications, 1991
A combination of DEAE-cellulose chromatography and reversed-phase high-performance liquid chromatography (HPLC) has been used to devise a method for generating large quantities of embryonic as well as fetal globin chains. The identity of these globin chains was further confirmed by their tryptic peptide mapping. This technique could, therefore, provide
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Stromal cell-dependent terminal maturation of K562 erythroleukaemia cells

Leukemia Research, 1991
K562 cells were cultured over monolayers of various cell types for four days and the characteristics of those cells which became firmly adherent to such monolayers studied. The monolayers used were composed of stromal cells derived from human bone marrow, two human fibroblast lines, human umbilical cord-derived endothelial cells, bone marrow ...
S R, Zuhrie, S N, Wickramasinghe
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Suppressor substance produced by the K562 cell line in vitro

Journal of Surgical Oncology, 1983
AbstractSupernatant fluids from three human cultured cell lines, K562, NALM‐1, and Daudi, all isolated from patients with lymphoreticular malignancies, were tested for suppressive activity toward normal lymphocytes in vitro. It was found that the K562 line elaborated material which effectively suppressed the response of normal human blood lymphocytes ...
J M, Korzelius, P M, Bealmear, O A, Holtermann   +2 more
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Erythroid properties of K562 cells

Experimental Cell Research, 1983
J.L. Villeval, P.G. Pelicci, A. Tabilio, M. Titeux, A. Henri, F. Houesche, P. Thomopoulos, W. Vainchenker, M. Garbaz, H. Rochant, J. Breton-Gorius, P.A.W. Edwards, U. Testa   +12 more
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