Results 1 to 10 of about 75,344 (250)
Antileukemic Activity of hsa-miR-203a-5p by Limiting Glutathione Metabolism in Imatinib-Resistant K562 Cells [PDF]
Current Issues in Molecular Biology, 2022 Imatinib has been the first and most successful tyrosine kinase inhibitor (TKI) for chronic myeloid leukemia (CML), but many patients develop resistance to it after a satisfactory response. Glutathione (GSH) metabolism is thought to be one of the factors
Priyanka Singh +3 more
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CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia
Cell Death Discovery, 2021 Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) confers poor prognosis and is found in approximately 25% of cases of acute myeloid leukemia (AML).
Sivasundaram Karnan +20 more
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X-ray-irradiated K562 feeder cells for expansion of functional CAR-T cells
Biochemistry and Biophysics Reports, 2023 Immunotherapy, particularly CAR-T therapy has recently emerged as an innovator for cancer treatment. Gamma-irradiated K562 cells is a common and effective method to stimulated CAR-T cells prior to treatment.
Khac Cuong Bui +12 more
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K562 human erythroleukemia cells demonstrate commitment [PDF]
Blood, 1985 Commitment, ie, the decision to express a differentiated phenotype and to terminate proliferation irreversibly in the absence of inducer, was investigated in K562 human erythroleukemia cells. Cells were cultured for 0, 1, 2, 3, or 4 days with inducer and then plated in medium containing methylcellulose without inducer.
P T, Rowley +2 more
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Toxicology Reports, 2022 The objective was to investigate the effect of 4-hydroxybenzoic acid (4-HBA) and 4-hydroxy-3-methoxybenzoic acid (Vanillic acid, VA) on p-glycoprotein (P-gp) activity in multidrug-resistant K562/Dox cancer cells.
Ohnmar Myint +5 more
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Proteomic Analysis of Quercetin-Treated K562 Cells [PDF]
International Journal of Molecular Sciences, 2019 Among natural products under investigation for their additive potential in cancer prevention and treatment, the flavonoid quercetin has received attention for its effects on the cell cycle arrest and apoptosis. In the past, we addressed this issue in K562 cells, a cellular model of the human chronic myeloid leukemia.
Brisdelli F. +7 more
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Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs
Retrovirology, 2022 Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such defense is the transcriptional silencing of incoming viral DNA, including the silencing of unintegrated retroviral DNA in most cells ...
Franziska K. Geis +2 more
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High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription. [PDF]
PLoS ONE, 2013 We examined the antileukemic effects of high concentrations of L-ascorbic acid (high AA) on human leukemic cells. In vitro, high AA markedly induced apoptosis in various leukemic cell lines by generating hydrogen peroxide (H2O2) but not in normal ...
Hiroshi Kawada +7 more
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Iterative endocytosis of transferrin by K562 cells [PDF]
Biochemical Journal, 1994 The effect of iron on the exocytosis of transferrin by K562 cells was studied by first allowing the cells to endocytose apotransferrin or diferric transferrin. Subsequent release of the apotransferrin was very rapid with a t 1/2 of 3.01 min, compared with 5.5 min for diferric transferrin.
S P, Young, A, Bomford
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Apoptosis Sensitization by Euphorbia Factor L1 in ABCB1-Mediated Multidrug Resistant K562/ADR Cells
Molecules, 2013 In this article, reversal activities of Euphorbia factor L1 (EFL1) against ABCB1-mediated multidrug resistance (MDR) and apoptosis sensitization in K562/ADR cells are reported.
Zhong-Zhen Zhao +7 more
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