Results 1 to 10 of about 41,280 (164)
Antileukemic Activity of hsa-miR-203a-5p by Limiting Glutathione Metabolism in Imatinib-Resistant K562 Cells [PDF]
Current Issues in Molecular Biology, 2022 Imatinib has been the first and most successful tyrosine kinase inhibitor (TKI) for chronic myeloid leukemia (CML), but many patients develop resistance to it after a satisfactory response. Glutathione (GSH) metabolism is thought to be one of the factors
Priyanka Singh +3 more
doaj +2 more sources
Acylphosphatase is involved in differentiation of K562 cells [PDF]
Cell Death and Differentiation, 1997 The level of both isoforms of acylphosphatase was evaluated in the human erythroleukemia K562 cell line during differentiation. K562 cells were treated with PMA, which induces megakaryocytic differentiation, and with aphidicolin or hemin, which stimulate erythrocytic differentiation. While the MT isoform showed an average 10-fold increase independently
Paola Chiarugi +2 more
exaly +4 more sources
Effects of P-Glycoprotein and Its Inhibitors on Apoptosis in K562 Cells
Molecules, 2014 P-glycoprotein (P-gp) is a major factor in multidrug resistance (MDR) which is a serious obstacle in chemotherapy. P-gp has also been implicated in causing apoptosis of tumor cells, which was shown to be another important mechanism of MDR recently.
Yaqiong Zu +4 more
doaj +3 more sources
Characterization of K562 cells: uncovering novel chromosomes, assessing transferrin receptor expression, and probing pharmacological therapies [PDF]
Cellular and Molecular Life Sciences, 2023 Assam El-Osta +2 more
exaly +2 more sources
CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia
Cell Death Discovery, 2021 Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) confers poor prognosis and is found in approximately 25% of cases of acute myeloid leukemia (AML).
Sivasundaram Karnan +20 more
doaj +1 more source
X-ray-irradiated K562 feeder cells for expansion of functional CAR-T cells
Biochemistry and Biophysics Reports, 2023 Immunotherapy, particularly CAR-T therapy has recently emerged as an innovator for cancer treatment. Gamma-irradiated K562 cells is a common and effective method to stimulated CAR-T cells prior to treatment.
Khac Cuong Bui +12 more
doaj +1 more source
Toxicology Reports, 2022 The objective was to investigate the effect of 4-hydroxybenzoic acid (4-HBA) and 4-hydroxy-3-methoxybenzoic acid (Vanillic acid, VA) on p-glycoprotein (P-gp) activity in multidrug-resistant K562/Dox cancer cells.
Ohnmar Myint +5 more
doaj +1 more source
Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs
Retrovirology, 2022 Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such defense is the transcriptional silencing of incoming viral DNA, including the silencing of unintegrated retroviral DNA in most cells ...
Franziska K. Geis +2 more
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Iterative endocytosis of transferrin by K562 cells [PDF]
Biochemical Journal, 1994 The effect of iron on the exocytosis of transferrin by K562 cells was studied by first allowing the cells to endocytose apotransferrin or diferric transferrin. Subsequent release of the apotransferrin was very rapid with a t 1/2 of 3.01 min, compared with 5.5 min for diferric transferrin.
S P, Young, A, Bomford
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Proteomic Analysis of Quercetin-Treated K562 Cells [PDF]
International Journal of Molecular Sciences, 2019 Among natural products under investigation for their additive potential in cancer prevention and treatment, the flavonoid quercetin has received attention for its effects on the cell cycle arrest and apoptosis. In the past, we addressed this issue in K562 cells, a cellular model of the human chronic myeloid leukemia.
Brisdelli F. +7 more
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