Results 41 to 50 of about 41,316 (200)

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Mn-Zn ferrite nanoparticles inducing ferroptosis to reverse the resistance in CML cells

Journal of Translational Medicine
Background Chronic myeloid leukemia (CML) is a malignant clonal disease of hematopoietic stem cells driven by the BCR-ABL fusion gene. Although tyrosine kinase inhibitors (TKIs) serve as targeted therapies, drug resistance remains one of the key ...
Miao Zhu, Yanqian Zhao, Li Xu, Mei Sun, Yuxiang Sun   +4 more
doaj   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Asperuloside regulates the proliferation, apoptosis, and differentiation of chronic myeloid leukemia cell line K562 through the RAS/MEK/ERK pathway

Heliyon
Context: Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disease caused by excessive proliferation and abnormal differentiation of hematopoietic stem cells.
Bingjie Zhao, Hong Che, Linlin Li, Lian Hu, Wenjing Yi, Li Xiao, Songshan Liu, Zhufa Hou   +7 more
doaj   +1 more source

Tetrandrine overcomes drug resistance mediated by bone marrow microenvironment by regulating the expression of P-glycoprotein in acute leukemia

Hematology, 2022
Objectives: To study the effect of TET on the reversal of drug resistance in the bone marrow microenvironment, and to further promote the research on drug reversal.Methods: We established a co-culture system of bone marrow mesenchymal stem cells (BM-MSC)
Xinyi Zhou, Nan Jin, Baoan Chen
doaj   +1 more source

Naturally Occurring Bicoumarin Compound Daphnoretin Inhibits Growth and Induces Megakaryocytic Differentiation in Human Chronic Myeloid Leukemia Cells

Cells, 2022
Daphnoretin extracted from the stem and roots of Wikstroemia indica (L.) C.A. Mey has been shown to possess antiviral and antitumor activities. Herein, we hypothesized that daphnoretin might induce megakaryocytic differentiation, thereby inhibiting the ...
Yu-Chuen Huang, Chun-Ping Huang, Chin-Ping Lin, Kai-Chien Yang, Yu-Jie Lei, Hao-Pei Wang, Yueh-Hsiung Kuo, Yu-Jen Chen   +7 more
doaj   +1 more source

Synthesis of Tris(indol‐3‐yl)methanes From Indoles, CO2, and Dimethylphenylsilane With BPh3: Two‐Step Construction of π‐Conjugated Systems

Chemistry – A European Journal, EarlyView.
Tris(indol‐3‐yl)methanes were synthesized from indoles, CO2, and PhMe2SiH in the presence of BPh3 in acetonitrile at 50°C. One product, tris(4‐bromo‐1‐methylindol‐3‐yl)methane, underwent a palladium‐catalyzed cascade reaction for the formation of a novel polycyclic heteroaromatic compound, where the methine C(sp3) atom originating from CO2 was ...
Sha Li, So Saibara, Reito Yasui, Kazuto Takaishi, Natsumi Nitta, Tadashi Ema   +5 more
wiley   +1 more source

Trifolium Repens Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway

Cells, 2020
Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action ...
Federica Sarno, Giacomo Pepe, Pasquale Termolino, Vincenzo Carafa, Crescenzo Massaro, Fabrizio Merciai, Pietro Campiglia, Angela Nebbioso, Lucia Altucci   +8 more
doaj   +1 more source

Knocking-down cyclin A(2) by siRNA suppresses apoptosis and switches differentiation pathways in K562 cells upon administration with doxorubicin. [PDF]

PLoS ONE, 2009
Cyclin A(2) is critical for the initiation of DNA replication, transcription and cell cycle regulation. Cumulative evidences indicate that the deregulation of cyclin A(2) is tightly linked to the chromosomal instability, neoplastic transformation and ...
Xiaohui Wang, Yujun Song, Jinsong Ren, Xiaogang Qu   +3 more
doaj   +1 more source

1‐(Acetylamino)thioxanthones and Derivatives: Synthesis From 1‐Halogenothioxanthones and Biological Properties

European Journal of Organic Chemistry, EarlyView.
The conversion of 1‐halogenothioxanthones into 1‐(acetylamino) derivatives and their NaH‐mediated cyclization have been optimized. This rapid method yields thiochromeno[4,3,2‐de]quinol‐2‐ones that exhibit promising in vitro anticancer activity. Institute and/or researcher Bluesky usernames: https://bsky.app/profile/iscr‐rennes.bsky.social.
Najet Ballagha, Frédéric Lassagne, William Erb, Isabelle Rouaud, Sophie Tomasi, Ziad Fajloun, Mona El Samarji, Mohamad Rima, Anamaria Mendonça Santos, Laurent Picot, Valérie Thiéry, Hédi M’Rabet, Florence Mongin   +12 more
wiley   +1 more source