K562 human erythroleukemia cells demonstrate commitment [PDF]
Blood, 1985 Commitment, ie, the decision to express a differentiated phenotype and to terminate proliferation irreversibly in the absence of inducer, was investigated in K562 human erythroleukemia cells. Cells were cultured for 0, 1, 2, 3, or 4 days with inducer and then plated in medium containing methylcellulose without inducer.
P T, Rowley +2 more
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Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib [PDF]
, 2009 <p><b>Objective:</b> To investigate the interaction of imatinib mesylate (IM) with the clinically relevant adenosine triphosphate-binding cassette efflux transporter MDR1 (ABCB1) in cells from patients with chronic myeloid leukemia (CML)
Holyoake, T.L. +4 more
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Genotoxikus hatásra bekövetkező funkcionális és strukturális DNS változások = Functional and structural changes in DNA upon genotoxic effects [PDF]
, 2008 Morfológiai és biokémiai vizsgálataink arra utalnak, hogy a a genotoxikus hatások kategorizálhatók az okozott kromatin változások alapján. A kemotoxikus változások potenciális diagnosztikus jelentősége miatt vizsgáltuk a nehézfémek (elsősosrban kadmium) (
Szepessy, Edit +6 more
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Growth inhibitory effects of etoposide in K562, K/VP.5, and K562/SSedit-2 cells.
, 2022 Growth inhibitory effects of etoposide in K562, K/VP.5, and K562/SSedit-2 cells.
Victor A. Hernandez (12647320) +5 more
core +1 more source
Assesment Of The Efficacy Of HESA-A On The Proliferation And Apoptosis Of Chronic Myelogenous Leukemia Cell Line(K562) [PDF]
پیاورد سلامت, 2012 Background and Aim: Chronic myelogenous leukemia is characterized by Philadelphia (Ph) chromosome, the presence of BCR-ABL fusion gene and constitutive activation of the ABL1 tyrosine kinase.
Mahdihe Ghasemi +5 more
doaj +1 more source
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells
ChemMedChem, 2017 AbstractSTAT5 is a transcription factor, a member of the STAT family of signaling proteins. STAT5 is involved in many types of cancer, including chronic myelogenous leukemia (CML), in which this protein is found constitutively activated as a consequence of BCR‐ABL expression. The neuroleptic drug pimozide was recently reported to act as an inhibitor of
Rondanin, Riccardo +8 more
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Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines
Saudi Pharmaceutical Journal, 2021 Background: Phytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-2) and phospholipase A2 ...
Affidah Sabran +5 more
doaj +1 more source
, 1982 In a study described in the chapter, cytotoxic potential of blood lymphocytes of vaccinated individuals was tested and the cells that interact with K562 cells were characterized.
Patarroyo, M +7 more
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The effect of membrane active agents on human leukaemia cells [PDF]
, 1998 This Thesis investigates the effect of membrane-active agents, such as synthetic ether lipids (SEL), local anaesthetics and polyunsaturated fatty acids (PUFAs) on human leukaemia cells.
Jones, Eirian Wynne
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source