Results 41 to 50 of about 10,434 (197)

individual gene knock outs in K562 cells-2

, 2023
This data (individual gene knock outs in K562 cells,1-8) includes bulk RNA sequencing data from individual gene knockouts K562 cells for 5 selected genes (KCTD5, EIF2AK1, APAF1, CCNC, IGF1R, triplicate samples for each) in addition to control guideRNA ...
Awad Shady
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

The effect of membrane active agents on human leukaemia cells [PDF]

, 1998
This Thesis investigates the effect of membrane-active agents, such as synthetic ether lipids (SEL), local anaesthetics and polyunsaturated fatty acids (PUFAs) on human leukaemia cells.
Jones, Eirian Wynne
core  

INCREASED ANTI K562 CYTOTOXICITY OF BLOOD MONONUCLEAR CELLS AFTER YELLOW FEVER VACCINATION, PROBABLY THE FUNCTION OF ACTIVATED T CELLS

, 1982
In a study described in the chapter, cytotoxic potential of blood lymphocytes of vaccinated individuals was tested and the cells that interact with K562 cells were characterized.
Patarroyo, M, Manuel Patarroyo, Fagraeus, A, Klein, E, Ehrnst, A, Eva Klein, Astrid Fagraeus, Anneka Ehrnst   +7 more
core   +1 more source

Lycorine attenuated proliferation and induced apoptosis on imatinib-resistant K562 cell by inhibiting autophagy

Discover Oncology
Background Tyrosine kinase inhibitor (TKI) resistance is a significant factor exacerbating the burden on chronic myeloid leukemia (CML) patients and impacting clinical efficacy.
Jun Bai, Zuxi Feng, Yaqiong Chen, Yanhong Li, Liansheng Zhang, Lijuan Li   +5 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Cellular morphology and proliferative properties of K562-IR cells.

, 2020
A. K562 parental cells (I). K562-IR cells 24h day after of a new passage. A few adherent cells are observed. (II). The proliferation of adherent K562-IR cells (III).
Eda Acikgoz (816259), Güner Hayri Özsan (8501598), Ahmet Sinan Yavuz (8501586), Öykü Gönül Geyik (8501589), Seda Baykal-Köse (8501583), Osman Uğur Sezerman (8501595), Halil Ateş (8501592), Zeynep Yüce (6556511)   +7 more
core   +1 more source

Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21

Frontiers in Immunology, 2019
Background: Natural Killer (NK) cell-based immunotherapy used to treat cancer requires the adoptive transfer of a large number of activated NK cells. Here, we report a new effective method to expand human NK cells ex vivo using K562 cells genetically ...
SoonHo Kweon, Minh-Trang Thi Phan, Sejong Chun, HongBi Yu, Jinho Kim, Seokho Kim, Jaemin Lee, Alaa Kassim Ali, Seung-Hwan Lee, Sang-Ki Kim, Junsang Doh, Duck Cho, Duck Cho, Duck Cho   +13 more
doaj   +1 more source

Cell cycle-independent upregulation of p27Kip1 by p21Waf1 in K562 cells [PDF]

Oncogene, 2001
Cellular differentiation frequently involves sequential peaks in the expression of cyclin-dependent kinase inhibitors (cdki's). For example, an increase in levels of the cdki p27Kip1 follows upregulation of p21Waf1 in several cell types induced to differentiate by diverse stimuli.
R A, Steinman, Y, Lu, B, Yaroslavskiy, C, Stehle   +3 more
openaire   +2 more sources

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source