Results 31 to 40 of about 10,434 (197)
K562-IR cells are resistant to TKIs and do not conform to known TKI resistance mechanisms.
, 2020 A. Cell viability of K562 and K562-IR cell treated with 10μM TKIs B. Cell viability of K562-IR cells treated with Cmax (daily clinical dose) concentrations. Flow cytometry analyses results were shown in the S1 Results of S1 Fig.
Eda Acikgoz (816259) +7 more
core +1 more source
Differences of basic and induced autophagic activity between K562 and K562/ADM cells
Intractable & Rare Diseases Research, 2017 Patients with acute myeloid leukemia (AML) often have a poor prognosis due to drug resistance, which is regarded as a tough problem during the period of clinical therapeutics. It has been reported that autophagy, an important event in various cellular processes, plays a crucial role in mediating drug-resistance to cancer cells.
Wang, Feifei +9 more
openaire +3 more sources
Journal of Experimental & Clinical Cancer Research, 2009 Background The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated. Methods K562 cells were cocultured with leukemic MSCs under serum deprivation. Cell Counting Kit-8
Liu Bin +9 more
doaj +1 more source
Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34+ cells to imatinib [PDF]
, 2009 <p><b>Objective:</b> To investigate the interaction of imatinib mesylate (IM) with the clinically relevant adenosine triphosphate-binding cassette efflux transporter MDR1 (ABCB1) in cells from patients with chronic myeloid leukemia (CML)
Holyoake, T.L. +4 more
core +1 more source
BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]
, 2012 MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Jørgensen, Heather G. +18 more
core +1 more source
Hemoglobin Expression in Clones of K562 Cell Line [PDF]
European Journal of Biochemistry, 1982 The K562 cell line was cloned by dilution and the pattern of hemoglobin (Hb) production was analyzed in the clones thus obtained. The pattern of hemoglobin synthesis was different from one clone to another. According to the Hb phenotype the clones were classified in three main groups; group I no detectable Hb; group II Hb Portland; group III Hb ...
U, Testa +9 more
openaire +2 more sources
Assesment Of The Efficacy Of HESA-A On The Proliferation And Apoptosis Of Chronic Myelogenous Leukemia Cell Line(K562) [PDF]
پیاورد سلامت, 2012 Background and Aim: Chronic myelogenous leukemia is characterized by Philadelphia (Ph) chromosome, the presence of BCR-ABL fusion gene and constitutive activation of the ABL1 tyrosine kinase.
Mahdihe Ghasemi +5 more
doaj +1 more source
Growth inhibitory effects of etoposide in K562, K/VP.5, and K562/SSedit-2 cells.
, 2022 Growth inhibitory effects of etoposide in K562, K/VP.5, and K562/SSedit-2 cells.
Victor A. Hernandez (12647320) +5 more
core +1 more source
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells
ChemMedChem, 2017 AbstractSTAT5 is a transcription factor, a member of the STAT family of signaling proteins. STAT5 is involved in many types of cancer, including chronic myelogenous leukemia (CML), in which this protein is found constitutively activated as a consequence of BCR‐ABL expression. The neuroleptic drug pimozide was recently reported to act as an inhibitor of
Rondanin, Riccardo +8 more
openaire +2 more sources
Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines
Saudi Pharmaceutical Journal, 2021 Background: Phytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-2) and phospholipase A2 ...
Affidah Sabran +5 more
doaj +1 more source