Results 31 to 40 of about 4,454,791 (262)

HA117 gene increased the multidrug resistance of K562 cells in vitro: an investigation to the function of a novel gene related to drug resistance

Journal of Experimental & Clinical Cancer Research, 2009
Objective A novel multi-drug resistance gene named as HA117 has been screened and cloned in multidrug resisitant leukemia cell lines in our previous research, but its function is still unknown.
Liu Xiaomei, Luo Qing, Xu Youhua, Jin Xianqing, Zheng Gaihuan, Guo Yuxia, Zhao Zhenzhen, Chen Yong   +7 more
doaj   +1 more source

K562-IR cells form intact tumor spheroids and express E-cadherin.

, 2020
A. Spheroid formation assay of K562 and K562-IR w/ IM (10μM) cells in agarose culture for 15 days. K562 cells do not form tumor spheroids whereas K562-IR cells show extensive spheroid formation (n = 3 biological replicate). Spheroid diameter measurements
Eda Acikgoz (816259), Güner Hayri Özsan (8501598), Ahmet Sinan Yavuz (8501586), Öykü Gönül Geyik (8501589), Seda Baykal-Köse (8501583), Osman Uğur Sezerman (8501595), Halil Ateş (8501592), Zeynep Yüce (6556511)   +7 more
core   +1 more source

CFTR in K562 human leukemic cells

American Journal of Physiology-Cell Physiology, 2003
In this study, the expression and functional characterization of CFTR (cystic fibrosis transmembrane regulator) was determined in K562 chronic human leukemia cells. Expression of the CFTR gene product was determined by RT-PCR and confirmed by immunohistochemistry and Western blot analysis.
Assef, Yanina Andrea, Damiano, Alicia Ermelinda, Zotta, Elsa, Ibarra, Cristina Adriana, Kotsias, Basilio Aristides   +4 more
openaire   +3 more sources

Hemoglobin Expression in Clones of K562 Cell Line [PDF]

European Journal of Biochemistry, 1982
The K562 cell line was cloned by dilution and the pattern of hemoglobin (Hb) production was analyzed in the clones thus obtained. The pattern of hemoglobin synthesis was different from one clone to another. According to the Hb phenotype the clones were classified in three main groups; group I no detectable Hb; group II Hb Portland; group III Hb ...
TESTA U., VAINCHENKER W., BEUZARD Y., ROUYER FESSARD P., GUERRASIO, Angelo, TITEUX M., LAPOTRE P., BOUGUET J., BRETON GORIUS J., ROSA J.   +9 more
openaire   +3 more sources

K562-IR cells are resistant to TKIs and do not conform to known TKI resistance mechanisms.

, 2020
A. Cell viability of K562 and K562-IR cell treated with 10μM TKIs B. Cell viability of K562-IR cells treated with Cmax (daily clinical dose) concentrations. Flow cytometry analyses results were shown in the S1 Results of S1 Fig.
Eda Acikgoz (816259), Güner Hayri Özsan (8501598), Ahmet Sinan Yavuz (8501586), Öykü Gönül Geyik (8501589), Seda Baykal-Köse (8501583), Osman Uğur Sezerman (8501595), Halil Ateş (8501592), Zeynep Yüce (6556511)   +7 more
core   +1 more source

Differences of basic and induced autophagic activity between K562 and K562/ADM cells

Intractable & Rare Diseases Research, 2017
Patients with acute myeloid leukemia (AML) often have a poor prognosis due to drug resistance, which is regarded as a tough problem during the period of clinical therapeutics. It has been reported that autophagy, an important event in various cellular processes, plays a crucial role in mediating drug-resistance to cancer cells.
Wang, Feifei, Chen, Jing, Zhang, Zhewen, Yi, Juan, Yuan, Minmin, Wang, Mingyan, Zhang, Na, Qiu, Xuemin, Wei, Hulai, Wang, Ling   +9 more
openaire   +3 more sources

Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells

Journal of Experimental & Clinical Cancer Research, 2009
Background The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated. Methods K562 cells were cocultured with leukemic MSCs under serum deprivation. Cell Counting Kit-8
Liu Bin, Lu ShiHong, Ren Qian, Xu Fangyun, Wang Xueming, Guo Hongxing, Chen Naiyao, Wei Zhaohui, Zhang Lei, Zhao Hui   +9 more
doaj   +1 more source

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]

, 2012
MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Jørgensen, Heather G., Holyoake, T.L., Holyoake, T., Abed El Baky, Mohamed, Bartholomew, C., Melo, Junia V., Roy, P., Melo, J.V., Abed El Baky, M., Roy, S., Jørgensen, H., Jorgensen, H.G., Strathdee, G., Strathdee, Gordon, Melo, J., Roy, Swagata, Holyoake, Tessa L., Roy, Poornima, Bartholomew, Christopher   +18 more
core   +1 more source

Apoptosis and mitotic slippage following drug intervention in leukaemia cells [PDF]

, 2011
PhDThe response of leukaemia cells to therapeutic agents includes cell cycle arrest and apoptosis. The former response is useful in retarding disease progression, but induction of the latter is essential for disease eradication.
Omar, Najood Amer
core   +4 more sources

HERG1 Currents in Native K562 Leukemic Cells

Journal of Membrane Biology, 2007
The human ether-a-go-go related gene (HERG1) K+ channel is expressed in neoplastic cells, in which it was proposed to play a role in proliferation, differentiation and/or apoptosis. K562 cells (a chronic myeloid leukemic human cell line) express both the full-length (herg1a) and the N-terminally truncated (herg1b) isoforms of the gene, and this was ...
Cavarra, Maria Soledad, del Monaco, Silvana Maria, Assef, Yanina Andrea, Ibarra, Cristina Adriana, Kotsias, Basilio Aristides   +4 more
openaire   +3 more sources