Results 31 to 40 of about 75,344 (250)

The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis [PDF]

, 2013
Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Courtial, Nadine, Herkt, Stefanie, Hussong, Helge, Kolodziej, Stephan, Lausen, Jörn, Mücke, Christian   +5 more
core   +2 more sources

Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells. [PDF]

, 2018
MicroRNAs, non-coding regulators of gene expression, are likely to function as important downstream effectors of many transcription factors including MYB. Optimal levels of MYB are required for transformation/maintenance of BCR-ABL-expressing cells.
Blandino, Giovanni, Calabretta, Bruno, Cordone, Iole, De Dominici, Marco, Korita, Etleva, Lulli, Valentina, Magenta, Alessandra, Marchesi, Francesco, Mengarelli, Andrea, Pelosi, Andrea, Pisani, Francesco, Regazzo, Giulia, Rizzo, Maria G., Sacconi, Andrea, Spagnuolo, Manuela, Strano, Sabrina   +15 more
core   +3 more sources

Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]

, 2009
The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele, De Martino, Luisa, Di Stefano, Carla, Fiorito, Filomena, Indelicato, Manuela, Marfe, Gabriella, Pucci, Bruna, Russo, Matteo A., Tafani, Marco   +8 more
core   +1 more source

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair. [PDF]

, 2020
Repair of double strand DNA breaks (DSBs) can result in gene disruption or gene modification via homology directed repair (HDR) from donor DNA. Altering cellular responses to DSBs may rebalance editing outcomes towards HDR and away from other repair ...
A Ferreira, A Montagnoli, A Orthwein, AC Komor, B Roberts, B Verdoodt, C Anders, C Yu, CD Richardson, CD Richardson, D Szklarczyk, DW Huang, E Lingeman, ES Koltun, FK Zimmermann, H Ghezraoui, J Song, JA Doudna, JE Haber, JP Duxin, K Jayathilaka, K Nakanishi, K Okita, KJ Livak, L Lei, L Pessoa-Brandão, LA Gilbert, LN Brandão, M Cavazzana, M Lei, M Yamada, MA DeWitt, MD Canny, MD Rainey, MH Porteus, N Hustedt, N Zielke, NK Sasi, NR Pannunzio, R Ceccaldi, RC Alver, S Hughes, S Lin, SB Thyme, T Maruyama, T Takenaka, T Tsuji, TA Day, TL Roth, TS Nambiar, U Eichenlaub-Ritter, VT Chu, W Li, X Liang, Z Romero   +54 more
core   +1 more source

Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy [PDF]

Toxicology Mechanisms and Methods, 2012
Arsenic trioxide (As(2)O(3)) has been reported to have potent antitumor effects in vitro and in vivo by inducing cell death via cell cycle arrest and apoptosis in leukemia cells, but the mechanisms of As(2)O(3)-mediated cell death are not fully understood.
Juan, Cheng, Hu-Lai, Wei, Jing, Chen, Bei, Xie   +3 more
openaire   +2 more sources

Assesment Of The Efficacy Of HESA-A On The Proliferation And Apoptosis Of Chronic Myelogenous Leukemia Cell Line(K562) [PDF]

پیاورد سلامت, 2012
Background and Aim: Chronic myelogenous leukemia is characterized by Philadelphia (Ph) chromosome, the presence of BCR-ABL fusion gene and constitutive activation of the ABL1 tyrosine kinase.
Mahdihe Ghasemi, Fatemeh Nadali, Seyed Naser Ostad, Farhad Zaker, Shahrbanoo Rostamy, Hossein Dargahi   +5 more
doaj   +1 more source

Differences of basic and induced autophagic activity between K562 and K562/ADM cells

Intractable & Rare Diseases Research, 2017
Patients with acute myeloid leukemia (AML) often have a poor prognosis due to drug resistance, which is regarded as a tough problem during the period of clinical therapeutics. It has been reported that autophagy, an important event in various cellular processes, plays a crucial role in mediating drug-resistance to cancer cells.
Feifei, Wang, Jing, Chen, Zhewen, Zhang, Juan, Yi, Minmin, Yuan, Mingyan, Wang, Na, Zhang, Xuemin, Qiu, Hulai, Wei, Ling, Wang   +9 more
openaire   +3 more sources

Calcitonin receptor gene expression in K562 chronic myelogenous leukemic cells

Cancer Cell International, 2003
Background The peptide hormone calcitonin (CT) can significantly effect the proliferation rate of CT receptor (CTR) positive human cancer cells. We wish to identify additional human cancers expressing CTRs and assay the effects of CT on their growth ...
Pondel Marc D, Mould Richard
doaj   +1 more source

Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines

Saudi Pharmaceutical Journal, 2021
Background: Phytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-2) and phospholipase A2 ...
Affidah Sabran, Endang Kumolosasi, Ibrahim Jantan, Jamia Azdina Jamal, Norazrina Azmi, Malina Jasamai   +5 more
doaj   +1 more source

Comparative proteomic analysis of differentially expressed proteins between K562 and K562/ADM cells

Chinese Medical Journal, 2008
Multidrug resistance to chemotherapeutic agents is an important clinical problem during the treatment of leukemia. The resistance process is multifactorial. To realize the total factors involved in multidrug resistance, we analyzed the differentially expressed proteins of K562 and K562/ADM cells and we investigated one of the up-regulated proteins ...
Shao-hua, Shen, Long-jun, Gu, Pei-qing, Liu, Xin, Ye, Wei-shan, Chang, Ben-shang, Li   +5 more
openaire   +2 more sources