Results 21 to 30 of about 4,454,791 (262)

Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs

Retrovirology, 2022
Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such defense is the transcriptional silencing of incoming viral DNA, including the silencing of unintegrated retroviral DNA in most cells ...
Franziska K. Geis, Demetra P. Kelenis, Stephen P. Goff   +2 more
doaj   +1 more source

Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy [PDF]

Toxicology Mechanisms and Methods, 2012
Arsenic trioxide (As(2)O(3)) has been reported to have potent antitumor effects in vitro and in vivo by inducing cell death via cell cycle arrest and apoptosis in leukemia cells, but the mechanisms of As(2)O(3)-mediated cell death are not fully understood.
Juan, Cheng, Hu-Lai, Wei, Jing, Chen, Bei, Xie   +3 more
openaire   +2 more sources

High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription. [PDF]

PLoS ONE, 2013
We examined the antileukemic effects of high concentrations of L-ascorbic acid (high AA) on human leukemic cells. In vitro, high AA markedly induced apoptosis in various leukemic cell lines by generating hydrogen peroxide (H2O2) but not in normal ...
Hiroshi Kawada, Mitsuyo Kaneko, Masakazu Sawanobori, Tomoko Uno, Hideyuki Matsuzawa, Yoshihiko Nakamura, Hiromichi Matsushita, Kiyoshi Ando   +7 more
doaj   +1 more source

Apoptosis Sensitization by Euphorbia Factor L1 in ABCB1-Mediated Multidrug Resistant K562/ADR Cells

Molecules, 2013
In this article, reversal activities of Euphorbia factor L1 (EFL1) against ABCB1-mediated multidrug resistance (MDR) and apoptosis sensitization in K562/ADR cells are reported.
Zhong-Zhen Zhao, Hu-Biao Chen, Lan-Lan Fan, Xi-Cheng He, Yi-Na Tang, Tao Yi, Jian-Ye Zhang, Min-Ting Lin   +7 more
doaj   +1 more source

hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]

PLoS ONE, 2013
The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma, Youtian Hu, Mingxiong Guo, Zan Huang, Wenxin Li, Yingliang Wu   +5 more
doaj   +1 more source

In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells [PDF]

International Journal of Biological Sciences, 2016
Chronic myelogenous leukemia (CML) is a malignant hematological disorder mainly caused by the Bcr-Abl tyrosine kinase. While Bcr-Abl inhibitors including Imatinib showed antitumor efficacy on many CML patients, resistance was frequently reported in recent years. Therefore, novel drugs for CML are still expected.
Zhou, Qianxiang, Chen, Yali, Chen, Xi, Zhao, Wennan, Zhong, Yuxu, Wang, Ran, Jin, Meihua, Qiu, Yuling, Kong, Dexin   +8 more
openaire   +2 more sources

Multi-Drug–Resistant Cells Enriched From Chronic Myeloid Leukemia Cells by Doxorubicin Possess Tumor-Initiating–Cell Properties

Journal of Pharmacological Sciences, 2013
Multiple drug resistance (MDR) occurring during chemotherapy is a major obstacle for treatment of cancers using chemotherapeutic drugs; thus, the mechanisms underlying MDR have attracted intensive attention.
Hong Xin, Ying Kong, Xiaoxiao Jiang, Ke Wang, Xiaoran Qin, Ze-Hong Miao, Yizhun Zhu, Wenfu Tan   +7 more
doaj   +1 more source

Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells

Cells, 2020
Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment.
Jui-Hung Yen, Ching-Yen Lin, Chin-Hsien Chuang, Hsien-Kuo Chin, Ming-Jiuan Wu, Pei-Yi Chen   +5 more
doaj   +1 more source

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]

, 2012
Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
Marie Docherty, Michelle Le Brocq, Brenda Gibson, Halsey, C., Derek Gilchrist, Docherty, M., Gilchrist, D., Gibson, B., McNeill, M., Christina Halsey, Halsey, Christina, Gerard Graham, Graham, G., Mhairi McNeill, Le Brocq, M., Gilchrist Derek, Halsey Christina, Gibson Brenda, McNeill Mhairi, Graham Gerard, Docherty Marie, Le Brocq Michelle   +21 more
core   +1 more source

Pinellia pedatisecta agglutinin targets drug resistant K562/ADR leukemia cells through binding with sarcolemmal membrane associated protein and enhancing macrophage phagocytosis. [PDF]

PLoS ONE, 2013
Pinelliapedatisecta agglutinin (PPA) has previously been used in labeling fractions of myeloid leukemia cells in our laboratory. We report here that a bacterial expressed recombinant PPA domain b tagged with soluble coxsackie and adenovirus receptor ...
Kan Chen, Xinyan Yang, Liqin Wu, Meilan Yu, Xiaoyan Li, Na Li, Shuanghui Wang, Gongchu Li   +7 more
doaj   +1 more source