Results 21 to 30 of about 41,316 (200)

K562 human erythroleukemia cells demonstrate commitment [PDF]

Blood, 1985
Commitment, ie, the decision to express a differentiated phenotype and to terminate proliferation irreversibly in the absence of inducer, was investigated in K562 human erythroleukemia cells. Cells were cultured for 0, 1, 2, 3, or 4 days with inducer and then plated in medium containing methylcellulose without inducer.
P T, Rowley, B M, Ohlsson-Wilhelm, B A, Farley   +2 more
openaire   +3 more sources

HERG1 Currents in Native K562 Leukemic Cells

Journal of Membrane Biology, 2007
The human ether-a-go-go related gene (HERG1) K+ channel is expressed in neoplastic cells, in which it was proposed to play a role in proliferation, differentiation and/or apoptosis. K562 cells (a chronic myeloid leukemic human cell line) express both the full-length (herg1a) and the N-terminally truncated (herg1b) isoforms of the gene, and this was ...
Cavarra, Maria Soledad, del Monaco, Silvana Maria, Assef, Yanina Andrea, Ibarra, Cristina Adriana, Kotsias, Basilio Aristides   +4 more
openaire   +3 more sources

Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells

Journal of Experimental & Clinical Cancer Research, 2009
Background The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated. Methods K562 cells were cocultured with leukemic MSCs under serum deprivation. Cell Counting Kit-8
Liu Bin, Lu ShiHong, Ren Qian, Xu Fangyun, Wang Xueming, Guo Hongxing, Chen Naiyao, Wei Zhaohui, Zhang Lei, Zhao Hui   +9 more
doaj   +1 more source

Differences of basic and induced autophagic activity between K562 and K562/ADM cells

Intractable & Rare Diseases Research, 2017
Patients with acute myeloid leukemia (AML) often have a poor prognosis due to drug resistance, which is regarded as a tough problem during the period of clinical therapeutics. It has been reported that autophagy, an important event in various cellular processes, plays a crucial role in mediating drug-resistance to cancer cells.
Wang, Feifei, Chen, Jing, Zhang, Zhewen, Yi, Juan, Yuan, Minmin, Wang, Mingyan, Zhang, Na, Qiu, Xuemin, Wei, Hulai, Wang, Ling   +9 more
openaire   +3 more sources

Hemoglobin Expression in Clones of K562 Cell Line [PDF]

European Journal of Biochemistry, 1982
The K562 cell line was cloned by dilution and the pattern of hemoglobin (Hb) production was analyzed in the clones thus obtained. The pattern of hemoglobin synthesis was different from one clone to another. According to the Hb phenotype the clones were classified in three main groups; group I no detectable Hb; group II Hb Portland; group III Hb ...
U, Testa, W, Vainchenker, Y, Beuzard, P, Rouyer-Fessard, A, Guerrasio, M, Titeux, P, Lapotre, J, Bouguet, J, Breton-Gorius, J, Rosa   +9 more
openaire   +2 more sources

Assesment Of The Efficacy Of HESA-A On The Proliferation And Apoptosis Of Chronic Myelogenous Leukemia Cell Line(K562) [PDF]

پیاورد سلامت, 2012
Background and Aim: Chronic myelogenous leukemia is characterized by Philadelphia (Ph) chromosome, the presence of BCR-ABL fusion gene and constitutive activation of the ABL1 tyrosine kinase.
Mahdihe Ghasemi, Fatemeh Nadali, Seyed Naser Ostad, Farhad Zaker, Shahrbanoo Rostamy, Hossein Dargahi   +5 more
doaj   +1 more source

Calcitonin receptor gene expression in K562 chronic myelogenous leukemic cells

Cancer Cell International, 2003
Background The peptide hormone calcitonin (CT) can significantly effect the proliferation rate of CT receptor (CTR) positive human cancer cells. We wish to identify additional human cancers expressing CTRs and assay the effects of CT on their growth ...
Pondel Marc D, Mould Richard
doaj   +1 more source

Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines

Saudi Pharmaceutical Journal, 2021
Background: Phytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-2) and phospholipase A2 ...
Affidah Sabran, Endang Kumolosasi, Ibrahim Jantan, Jamia Azdina Jamal, Norazrina Azmi, Malina Jasamai   +5 more
doaj   +1 more source

Effects of Pimozide Derivatives on pSTAT5 in K562 Cells

ChemMedChem, 2017
AbstractSTAT5 is a transcription factor, a member of the STAT family of signaling proteins. STAT5 is involved in many types of cancer, including chronic myelogenous leukemia (CML), in which this protein is found constitutively activated as a consequence of BCR‐ABL expression. The neuroleptic drug pimozide was recently reported to act as an inhibitor of
Rondanin, Riccardo, Simoni, Daniele, Maccesi, Martina, Romagnoli, Romeo, Grimaudo, Stefania, Pipitone, Rosaria Maria, Meli, Maria, Cascio, Antonio, Tolomeo, Manlio   +8 more
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source