Results 21 to 30 of about 10,434 (197)

hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]

PLoS ONE, 2013
The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma, Youtian Hu, Mingxiong Guo, Zan Huang, Wenxin Li, Yingliang Wu   +5 more
doaj   +1 more source

Pinellia pedatisecta agglutinin targets drug resistant K562/ADR leukemia cells through binding with sarcolemmal membrane associated protein and enhancing macrophage phagocytosis. [PDF]

PLoS ONE, 2013
Pinelliapedatisecta agglutinin (PPA) has previously been used in labeling fractions of myeloid leukemia cells in our laboratory. We report here that a bacterial expressed recombinant PPA domain b tagged with soluble coxsackie and adenovirus receptor ...
Kan Chen, Xinyan Yang, Liqin Wu, Meilan Yu, Xiaoyan Li, Na Li, Shuanghui Wang, Gongchu Li   +7 more
doaj   +1 more source

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]

, 2012
Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
Marie Docherty, Michelle Le Brocq, Brenda Gibson, Halsey, C., Derek Gilchrist, Docherty, M., Gilchrist, D., Gibson, B., McNeill, M., Christina Halsey, Halsey, Christina, Gerard Graham, Graham, G., Mhairi McNeill, Le Brocq, M.   +14 more
core   +1 more source

Multi-Drug–Resistant Cells Enriched From Chronic Myeloid Leukemia Cells by Doxorubicin Possess Tumor-Initiating–Cell Properties

Journal of Pharmacological Sciences, 2013
Multiple drug resistance (MDR) occurring during chemotherapy is a major obstacle for treatment of cancers using chemotherapeutic drugs; thus, the mechanisms underlying MDR have attracted intensive attention.
Hong Xin, Ying Kong, Xiaoxiao Jiang, Ke Wang, Xiaoran Qin, Ze-Hong Miao, Yizhun Zhu, Wenfu Tan   +7 more
doaj   +1 more source

Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells

Cells, 2020
Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment.
Jui-Hung Yen, Ching-Yen Lin, Chin-Hsien Chuang, Hsien-Kuo Chin, Ming-Jiuan Wu, Pei-Yi Chen   +5 more
doaj   +1 more source

HA117 gene increased the multidrug resistance of K562 cells in vitro: an investigation to the function of a novel gene related to drug resistance

Journal of Experimental & Clinical Cancer Research, 2009
Objective A novel multi-drug resistance gene named as HA117 has been screened and cloned in multidrug resisitant leukemia cell lines in our previous research, but its function is still unknown.
Liu Xiaomei, Luo Qing, Xu Youhua, Jin Xianqing, Zheng Gaihuan, Guo Yuxia, Zhao Zhenzhen, Chen Yong   +7 more
doaj   +1 more source

K562 human erythroleukemia cells demonstrate commitment [PDF]

Blood, 1985
Commitment, ie, the decision to express a differentiated phenotype and to terminate proliferation irreversibly in the absence of inducer, was investigated in K562 human erythroleukemia cells. Cells were cultured for 0, 1, 2, 3, or 4 days with inducer and then plated in medium containing methylcellulose without inducer.
P T, Rowley, B M, Ohlsson-Wilhelm, B A, Farley   +2 more
openaire   +3 more sources

CFTR in K562 human leukemic cells

American Journal of Physiology-Cell Physiology, 2003
In this study, the expression and functional characterization of CFTR (cystic fibrosis transmembrane regulator) was determined in K562 chronic human leukemia cells. Expression of the CFTR gene product was determined by RT-PCR and confirmed by immunohistochemistry and Western blot analysis.
Assef, Yanina Andrea, Damiano, Alicia Ermelinda, Zotta, Elsa, Ibarra, Cristina Adriana, Kotsias, Basilio Aristides   +4 more
openaire   +3 more sources

K562-IR cells form intact tumor spheroids and express E-cadherin.

, 2020
A. Spheroid formation assay of K562 and K562-IR w/ IM (10μM) cells in agarose culture for 15 days. K562 cells do not form tumor spheroids whereas K562-IR cells show extensive spheroid formation (n = 3 biological replicate). Spheroid diameter measurements
Eda Acikgoz (816259), Güner Hayri Özsan (8501598), Ahmet Sinan Yavuz (8501586), Öykü Gönül Geyik (8501589), Seda Baykal-Köse (8501583), Osman Uğur Sezerman (8501595), Halil Ateş (8501592), Zeynep Yüce (6556511)   +7 more
core   +1 more source

HERG1 Currents in Native K562 Leukemic Cells

Journal of Membrane Biology, 2007
The human ether-a-go-go related gene (HERG1) K+ channel is expressed in neoplastic cells, in which it was proposed to play a role in proliferation, differentiation and/or apoptosis. K562 cells (a chronic myeloid leukemic human cell line) express both the full-length (herg1a) and the N-terminally truncated (herg1b) isoforms of the gene, and this was ...
Cavarra, Maria Soledad, del Monaco, Silvana Maria, Assef, Yanina Andrea, Ibarra, Cristina Adriana, Kotsias, Basilio Aristides   +4 more
openaire   +3 more sources