Results 21 to 30 of about 75,344 (250)

Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures. [PDF]

, 2014
Telomerase is a reverse transcriptase that maintains telomeres on the ends of chromosomes, allowing rapidly dividing cells to proliferate while avoiding senescence and apoptosis.
Hart, Kristina, Mathies, Richard A, Novak, Richard   +2 more
core   +1 more source

The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis [PDF]

, 2007
Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Cheng Zhu, Periasamy Selvaraj, Timothy P. Tolentino   +2 more
core   +2 more sources

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus [PDF]

, 2012
The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional folding of a 1 Mbp
Ann Dean, Bau, Bau, Bender, Bender, Botta, Chunhui Hou, Cook, Cui, de Gennes, Dekker, Dorier, Dostie, Drissen, Duan, Farrell, François Képès, Fraser, Hadjur, Handoko, Hou, Hou, Ivan Junier, Junier, Kalhor, Kiefer, Kim, Krivega, Kurukuti, Langowski, Lee, Lieberman-Aiden, Marenduzzo, Mateos-Langerak, Mukhopadhyay, Murrell, Ong, Palstra, Phillips, Ragoczy, Reuillon, Rosa, Rousseau, Ryan K. Dale, Schoenfelder, Sexton, Sexton, Simonis, Song, Song, Splinter, Stamatoyannopoulos, Strick, Tolhuis, Vakoc, Wallace, Yaffe   +56 more
core   +6 more sources

HERG1 Currents in Native K562 Leukemic Cells

Journal of Membrane Biology, 2007
The human ether-a-go-go related gene (HERG1) K+ channel is expressed in neoplastic cells, in which it was proposed to play a role in proliferation, differentiation and/or apoptosis. K562 cells (a chronic myeloid leukemic human cell line) express both the full-length (herg1a) and the N-terminally truncated (herg1b) isoforms of the gene, and this was ...
Cavarra, Maria Soledad, del Monaco, Silvana Maria, Assef, Yanina Andrea, Ibarra, Cristina Adriana, Kotsias, Basilio Aristides   +4 more
openaire   +3 more sources

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
A Quintas-Cardama, A Quintas-Cardama, A Quintas-Cardama, AJ Tipping, AJ Tipping, B Zhang, C Akgul, C Bellodi, G Gurel, H de Lavallade, H Konig, HG Jorgensen, HM Kantarjian, J Kuroda, KJ Aichberger, L Legros, M Copland, M Copland, NB Heaney, R Chen, R Tang, RG Powell, RM Stone, S Chu, SM Graham, SV Sharma, T Kobayashi, Y Chen   +27 more
core   +1 more source

Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP. [PDF]

, 2017
Platelet activation in response to stimulation of the Protease Activated Receptor 4 (PAR4) receptor differs by race. One factor that contributes to this difference is the expression level of Phosphatidylcholine Transfer Protein (PCTP), a regulator of ...
Bray, Paul F., Edelstein, Leonard C., Holinstat, Michael, Kong, Xianguo, Shaw, Chad A., Simon, Lukas M.   +5 more
core   +3 more sources

Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells

Journal of Experimental & Clinical Cancer Research, 2009
Background The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated. Methods K562 cells were cocultured with leukemic MSCs under serum deprivation. Cell Counting Kit-8
Liu Bin, Lu ShiHong, Ren Qian, Xu Fangyun, Wang Xueming, Guo Hongxing, Chen Naiyao, Wei Zhaohui, Zhang Lei, Zhao Hui   +9 more
doaj   +1 more source

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]

, 2018
The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core   +1 more source

A new principle of cell sorting by using selective electroporation in a modified flow cytometer [PDF]

, 1990
When a strong electric field pulse of a few microseconds is applied to biological cells, small pores are formed in the cell membranes; this process is called electroporation.
Bakker Schut, Tom C., Greve, Jan, Grooth, Bart G. de   +2 more
core   +8 more sources

In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells [PDF]

International Journal of Biological Sciences, 2016
Chronic myelogenous leukemia (CML) is a malignant hematological disorder mainly caused by the Bcr-Abl tyrosine kinase. While Bcr-Abl inhibitors including Imatinib showed antitumor efficacy on many CML patients, resistance was frequently reported in recent years. Therefore, novel drugs for CML are still expected.
Zhou, Qianxiang, Chen, Yali, Chen, Xi, Zhao, Wennan, Zhong, Yuxu, Wang, Ran, Jin, Meihua, Qiu, Yuling, Kong, Dexin   +8 more
openaire   +2 more sources