Results 11 to 20 of about 4,454,791 (262)
Antileukemic Activity of hsa-miR-203a-5p by Limiting Glutathione Metabolism in Imatinib-Resistant K562 Cells [PDF]
Current Issues in Molecular Biology, 2022 Imatinib has been the first and most successful tyrosine kinase inhibitor (TKI) for chronic myeloid leukemia (CML), but many patients develop resistance to it after a satisfactory response. Glutathione (GSH) metabolism is thought to be one of the factors
Priyanka Singh +3 more
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Proteomic Analysis of Quercetin-Treated K562 Cells [PDF]
International Journal of Molecular Sciences, 2019 Among natural products under investigation for their additive potential in cancer prevention and treatment, the flavonoid quercetin has received attention for its effects on the cell cycle arrest and apoptosis. In the past, we addressed this issue in K562 cells, a cellular model of the human chronic myeloid leukemia.
Brisdelli F. +7 more
core +5 more sources
Effects of P-Glycoprotein and Its Inhibitors on Apoptosis in K562 Cells
Molecules, 2014 P-glycoprotein (P-gp) is a major factor in multidrug resistance (MDR) which is a serious obstacle in chemotherapy. P-gp has also been implicated in causing apoptosis of tumor cells, which was shown to be another important mechanism of MDR recently.
Yaqiong Zu +4 more
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Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21
Frontiers in Immunology, 2019 Background: Natural Killer (NK) cell-based immunotherapy used to treat cancer requires the adoptive transfer of a large number of activated NK cells. Here, we report a new effective method to expand human NK cells ex vivo using K562 cells genetically ...
SoonHo Kweon +13 more
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Calcitonin receptor gene expression in K562 chronic myelogenous leukemic cells [PDF]
Cancer Cell International, 2003 Background The peptide hormone calcitonin (CT) can significantly effect the proliferation rate of CT receptor (CTR) positive human cancer cells. We wish to identify additional human cancers expressing CTRs and assay the effects of CT on their growth ...
Pondel Marc D, Mould Richard
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CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia
Cell Death Discovery, 2021 Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) confers poor prognosis and is found in approximately 25% of cases of acute myeloid leukemia (AML).
Sivasundaram Karnan +20 more
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X-ray-irradiated K562 feeder cells for expansion of functional CAR-T cells
Biochemistry and Biophysics Reports, 2023 Immunotherapy, particularly CAR-T therapy has recently emerged as an innovator for cancer treatment. Gamma-irradiated K562 cells is a common and effective method to stimulated CAR-T cells prior to treatment.
Khac Cuong Bui +12 more
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Toxicology Reports, 2022 The objective was to investigate the effect of 4-hydroxybenzoic acid (4-HBA) and 4-hydroxy-3-methoxybenzoic acid (Vanillic acid, VA) on p-glycoprotein (P-gp) activity in multidrug-resistant K562/Dox cancer cells.
Ohnmar Myint +5 more
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Acylphosphatase is involved in differentiation of K562 cells [PDF]
Cell Death & Differentiation, 1997 The level of both isoforms of acylphosphatase was evaluated in the human erythroleukemia K562 cell line during differentiation. K562 cells were treated with PMA, which induces megakaryocytic differentiation, and with aphidicolin or hemin, which stimulate erythrocytic differentiation. While the MT isoform showed an average 10-fold increase independently
CHIARUGI, PAOLA +6 more
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Iterative endocytosis of transferrin by K562 cells [PDF]
Biochemical Journal, 1994 The effect of iron on the exocytosis of transferrin by K562 cells was studied by first allowing the cells to endocytose apotransferrin or diferric transferrin. Subsequent release of the apotransferrin was very rapid with a t 1/2 of 3.01 min, compared with 5.5 min for diferric transferrin.
S P, Young, A, Bomford
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