Results 11 to 20 of about 10,434 (197)
Effects of P-Glycoprotein and Its Inhibitors on Apoptosis in K562 Cells
Molecules, 2014 P-glycoprotein (P-gp) is a major factor in multidrug resistance (MDR) which is a serious obstacle in chemotherapy. P-gp has also been implicated in causing apoptosis of tumor cells, which was shown to be another important mechanism of MDR recently.
Yaqiong Zu +4 more
doaj +3 more sources
CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia
Cell Death Discovery, 2021 Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) confers poor prognosis and is found in approximately 25% of cases of acute myeloid leukemia (AML).
Sivasundaram Karnan +20 more
doaj +1 more source
Toxicology Reports, 2022 The objective was to investigate the effect of 4-hydroxybenzoic acid (4-HBA) and 4-hydroxy-3-methoxybenzoic acid (Vanillic acid, VA) on p-glycoprotein (P-gp) activity in multidrug-resistant K562/Dox cancer cells.
Ohnmar Myint +5 more
doaj +1 more source
Iterative endocytosis of transferrin by K562 cells [PDF]
Biochemical Journal, 1994 The effect of iron on the exocytosis of transferrin by K562 cells was studied by first allowing the cells to endocytose apotransferrin or diferric transferrin. Subsequent release of the apotransferrin was very rapid with a t 1/2 of 3.01 min, compared with 5.5 min for diferric transferrin.
S P, Young, A, Bomford
openaire +2 more sources
Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs
Retrovirology, 2022 Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such defense is the transcriptional silencing of incoming viral DNA, including the silencing of unintegrated retroviral DNA in most cells ...
Franziska K. Geis +2 more
doaj +1 more source
Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy [PDF]
Toxicology Mechanisms and Methods, 2012 Arsenic trioxide (As(2)O(3)) has been reported to have potent antitumor effects in vitro and in vivo by inducing cell death via cell cycle arrest and apoptosis in leukemia cells, but the mechanisms of As(2)O(3)-mediated cell death are not fully understood.
Juan, Cheng +3 more
openaire +2 more sources
High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription. [PDF]
PLoS ONE, 2013 We examined the antileukemic effects of high concentrations of L-ascorbic acid (high AA) on human leukemic cells. In vitro, high AA markedly induced apoptosis in various leukemic cell lines by generating hydrogen peroxide (H2O2) but not in normal ...
Hiroshi Kawada +7 more
doaj +1 more source
Current Issues in Molecular Biology, 2022 Imatinib has been the first and most successful tyrosine kinase inhibitor (TKI) for chronic myeloid leukemia (CML), but many patients develop resistance to it after a satisfactory response. Glutathione (GSH) metabolism is thought to be one of the factors
Priyanka Singh +3 more
doaj +1 more source
Apoptosis Sensitization by Euphorbia Factor L1 in ABCB1-Mediated Multidrug Resistant K562/ADR Cells
Molecules, 2013 In this article, reversal activities of Euphorbia factor L1 (EFL1) against ABCB1-mediated multidrug resistance (MDR) and apoptosis sensitization in K562/ADR cells are reported.
Zhong-Zhen Zhao +7 more
doaj +1 more source
In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells [PDF]
International Journal of Biological Sciences, 2016 Chronic myelogenous leukemia (CML) is a malignant hematological disorder mainly caused by the Bcr-Abl tyrosine kinase. While Bcr-Abl inhibitors including Imatinib showed antitumor efficacy on many CML patients, resistance was frequently reported in recent years. Therefore, novel drugs for CML are still expected.
Zhou, Qianxiang +8 more
openaire +2 more sources