Results 1 to 10 of about 3,694 (142)

P481: FAILURE OF BONE MARROW ERYTHROPOIESIS IN ACUTE MYELOID LEUKEMIA IS DRIVEN BY LOSS OF ERYTHROBLASTIC ISLANDS [PDF]

HemaSphere, 2023
Laura Mosteo, Lidia Rocha, Ana Raquel Maceiras, Bruno Cavadas, Carolina Pereira, Marta Lopes, Sérgio Chacim, Inês Ramos, Edwin Hawkins, José Mário Mariz, Graça Porto, Delfim Duarte   +11 more
doaj   +3 more sources

Autopsy findings of acute erythroid leukemia [PDF]

Autopsy and Case Reports, 2023
Acute erythroid leukemia (AEL) is an exceedingly uncommon but distinct hematological malignancy that shows neoplastic proliferation of erythroid precursors with maturation arrest and no significant myeloblasts.
Mayur Parkhi, Nabhajit Mallik, Deepesh Lad, Man Updesh Singh Sachdeva, Amanjit Bal, Pankaj Malhotra, Suvradeep Mitra   +6 more
doaj   +3 more sources

Erbin: an important therapeutic target for blocking tumor metastasis [PDF]

Frontiers in Pharmacology
Erbin is an adapter protein that interacts with the v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) in epithelial cells. Erbin plays an important role in various signaling pathways, including cell proliferation, apoptosis, and ...
Tingting Qiu, Liquan Tan, Jialong Yan, Qunli Luo   +3 more
doaj   +2 more sources

CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions [PDF]

Acta Neuropathologica Communications
Erythroblastic sarcoma (ES) (previously called chloroma or granulocytic sarcoma) are rare hematological neoplams characterized by the proliferation of myeloid blasts at extramedullary sites, and primarily involve the skin and soft tissue of middle-aged ...
Arnault Tauziède-Espariat, Lucille Lew-Derivry, Samuel Abbou, Alice Métais, Gaëlle Pierron, Stéphanie Reynaud, Julien Masliah-Planchon, Cassandra Mariet, Lauren Hasty, Volodia Dangouloff-Ros, Nathalie Boddaert, Marie Csanyi, Aude Aline-Fardin, Claire Lamaison, Fabrice Chrétien, Kévin Beccaria, Stéphanie Puget, Pascale Varlet   +17 more
doaj   +2 more sources

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications [PDF]

Blood Advances, 2020
AbstractAcute myeloid leukemia (AML) is a heterogeneous disease with poor prognosis and limited treatment strategies. Determining the role of cell-extrinsic regulators of leukemic cells is vital to gain clinical insights into the biology of AML. Iron is a key extrinsic regulator of cancer but its systemic regulation remains poorly explored in AML.
Marta Lopes, Tiago L. Duarte, Maria J. Teles, Laura Mosteo, Sérgio Chacim, Eliana Aguiar, Joana Pereira-Reis, Mónica Oliveira, André M. N. Silva, Nuno Gonçalves, Gabriela Martins, Isabella Y. Kong, Magnus Zethoven, Stephin Vervoort, Sandra Martins, Miguel Quintela, Edwin D Hawkins, Fernanda Trigo, João T. Guimarães, José M. Mariz, Graça Porto, Delfim Duarte   +21 more
openaire   +3 more sources

Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing [PDF]

, 2012
Pancreatic adenocarcinoma (PAC) is among the most lethal malignancies. While research has implicated multiple genes in disease pathogenesis, identification of therapeutic leads has been difficult and the majority of currently available therapies provide ...
Aldrich, Jessica, Baker, Angela, Barrett, Michael, Benson, Hollie, Borad, Mitesh J., Braggio, Esteban, Carpten, John, Christoforides, Alexis, Craig, David W., Demeure, Michael J., Egan, Jan B., Fonseca, Rafael, Han, Haiyong, Hostetter, Galen H., Izatt, Tyler, Kiefer, Jeffrey A., Kurdoglu, Ahmet, Lake, Douglas, Legendre, Christophe, Liang, Winnie S., Phillips, Lori, Posner, Richard, Ramanathan, Ramesh K., Sinari, Shripad, Stewart, A. Keith, Stites, Edward C., Tembe, Waibhav, Von Hoff, Daniel, Weiss, Glen J.   +28 more
core   +15 more sources

Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic leukemia [PDF]

Blood, 1992
Abstract We have performed a retrospective analysis of the clinical, morphologic, and cytogenetic findings in 26 patients diagnosed between January 1969 and September 1991 with acute erythroblastic leukemia de novo (EL or AML-M6). Clonal chromosomal abnormalities were found in 20 (77%) patients (95% confidence interval [CI], 61% to 93%).
O I, Olopade, M, Thangavelu, R A, Larson, R, Mick, A, Kowal-Vern, H R, Schumacher, M M, Le Beau, J W, Vardiman, J D, Rowley   +8 more
openaire   +3 more sources

Acute erythroid leukemia: autopsy report of a rare disease

Autopsy and Case Reports, 2011
Acute erythroid leukemia (AEL) is a rare subtype of acute myeloid leukemia (AML), characterized by predominant erythroid proliferation. The 2008 World Health Organization (WHO) classification of AML defined two AEL subtypes: erythroleukaemia (EL), in ...
Cristiane Rúbia Ferreira, Fabiana Roberto Lima, Edna Harumi Goto, Elizabeth In Myung Kim, Luciana Andréa Avena Smeili, Fernando Peixoto Ferraz de Campos, Maria Claudia Nogueira Zerbini   +6 more
doaj   +1 more source

Biochemical Abnormality of DNA Synthesis of Erythroblasts in Acute and Chronic Myeloid Leukemia [PDF]

Blood, 1973
Abstract Six patients with acute and chronic myeloid leukemia (AML and CML) showed a low incorporation of labeled DNA precursors into basophilic erythroblasts. Based on mitotic indices and the use of vincristine as a stathmokinetic tool, it was evident that brisk proliferation in this cell compartment took place.
P, Ernst, M, Baccarani, S A, Killmann
openaire   +2 more sources

Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction [PDF]

, 2015
published_or_final_versio
Chai, YH, Chiu, S, Ding, Y, GAO, F, He, J, Lian, Q, Liang, X, Tse, HF, Zhang, Y   +8 more
core   +1 more source