Results 1 to 10 of about 2,190 (132)

P481: FAILURE OF BONE MARROW ERYTHROPOIESIS IN ACUTE MYELOID LEUKEMIA IS DRIVEN BY LOSS OF ERYTHROBLASTIC ISLANDS [PDF]

HemaSphere, 2023
Laura Mosteo, Lidia Rocha, Ana Raquel Maceiras, Bruno Cavadas, Carolina Pereira, Marta Lopes, Sérgio Chacim, Inês Ramos, Edwin Hawkins, José Mário Mariz, Graça Porto, Delfim Duarte   +11 more
doaj   +3 more sources

The NFIA::CBFA2T3 identifies a molecularly defined subgroup of acute erythroid leukemia/erythroid sarcoma [PDF]

Frontiers in Oncology
IntroductionThe World Health Organization classification of tumors of hematopoietic and lymphoid tissues recognizes acute erythroid leukemia as a distinct entity under myeloid neoplasms.
Marta Brunetti, Kristin Andersen, Geir Erland Tjønnfjord, Geir Erland Tjønnfjord, Geir Erland Tjønnfjord, Bernward Zeller, Signe Spetalen, Signe Spetalen, Monica Cheng Munthe-Kaas, Liv Toril Nygård Osnes, Tina Treu Os, Francesca Micci   +11 more
doaj   +2 more sources

Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study. [PDF]

J Pathol Clin Res
Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Jenei A, Kajtár B, László T, Juratli HA, Vida L, Szepesi Á, Mózes R, Timár B, Halter J, Dirnhofer S, Tzankov A.   +10 more
europepmc   +2 more sources

Could Old-School Erythroleukaemia be Back in Style Thanks to <i>TP53</i>? [PDF]

EJHaem
eJHaem, Volume 6, Issue 4, August 2025.
Rieu JB, Canali A, Comont T, Ousset L, De Mas V.   +4 more
europepmc   +2 more sources

Masking as Myelofibrosis: A Case of Tp53 Mutated Acute Erythroid Leukemia Presenting With Pancytopenia and Bone Pain. [PDF]

Case Rep Hematol
Acute erythroid leukemia is a rare form of acute myeloid leukemia, comprising only 1% of myelogenous leukemia diagnoses. Presentations can vary and given its aggressive nature, prompt investigation and appropriate treatment are needed when suspicions arise. Here, we discuss a case of a 54‐year‐old male who initially presented with worsening fatigue and
Parker K, Cutrer RC.
europepmc   +2 more sources

Erbin: an important therapeutic target for blocking tumor metastasis [PDF]

Frontiers in Pharmacology
Erbin is an adapter protein that interacts with the v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) in epithelial cells. Erbin plays an important role in various signaling pathways, including cell proliferation, apoptosis, and ...
Tingting Qiu, Liquan Tan, Jialong Yan, Qunli Luo   +3 more
doaj   +2 more sources

Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis. [PDF]

Hemasphere
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
El Hoss S, Lizarralde-Iragorri MA, Maciel TT, Hermine O.   +3 more
europepmc   +2 more sources

CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions [PDF]

Acta Neuropathologica Communications
Erythroblastic sarcoma (ES) (previously called chloroma or granulocytic sarcoma) are rare hematological neoplams characterized by the proliferation of myeloid blasts at extramedullary sites, and primarily involve the skin and soft tissue of middle-aged ...
Arnault Tauziède-Espariat, Lucille Lew-Derivry, Samuel Abbou, Alice Métais, Gaëlle Pierron, Stéphanie Reynaud, Julien Masliah-Planchon, Cassandra Mariet, Lauren Hasty, Volodia Dangouloff-Ros, Nathalie Boddaert, Marie Csanyi, Aude Aline-Fardin, Claire Lamaison, Fabrice Chrétien, Kévin Beccaria, Stéphanie Puget, Pascale Varlet   +17 more
doaj   +2 more sources

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications [PDF]

Blood Advances, 2020
Abstract Acute myeloid leukemia (AML) is a heterogeneous disease with poor prognosis and limited treatment strategies. Determining the role of cell-extrinsic regulators of leukemic cells is vital to gain clinical insights into the biology of AML.
Marta Lopes, Tiago L. Duarte, Maria J. Teles, Laura Mosteo, Sérgio Chacim, Eliana Aguiar, Joana Pereira-Reis, Mónica Oliveira, André M. N. Silva, Nuno Gonçalves, Gabriela Martins, Isabella Y. Kong, Magnus Zethoven, Stephin Vervoort, Sandra Martins, Miguel Quintela, Edwin D Hawkins, Fernanda Trigo, João T. Guimarães, José M. Mariz, Graça Porto, Delfim Duarte   +21 more
openaire   +3 more sources

Clinical, morphologic, and cytogenetic characteristics of 26 patients with acute erythroblastic leukemia [PDF]

Blood, 1992
Abstract We have performed a retrospective analysis of the clinical, morphologic, and cytogenetic findings in 26 patients diagnosed between January 1969 and September 1991 with acute erythroblastic leukemia de novo (EL or AML-M6). Clonal chromosomal abnormalities were found in 20 (77%) patients (95% confidence interval [CI], 61% to 93%).
O I, Olopade, M, Thangavelu, R A, Larson, R, Mick, A, Kowal-Vern, H R, Schumacher, M M, Le Beau, J W, Vardiman, J D, Rowley   +8 more
openaire   +3 more sources