Results 11 to 20 of about 1,571,779 (177)

Adult Erythroblastic Sarcoma With PCM1::JAK2 Fusion and a Novel NOP10::NUTM1 Fusion Complicated by Secondary HLH. [PDF]

J Cell Mol Med
ABSTRACT Erythroblastic sarcoma is a rare and aggressive hematologic malignancy presenting as a mass‐forming extramedullary proliferation of immature erythroid cells. Myeloid/lymphoid neoplasms with JAK2 rearrangement, most often PCM1::JAK2, may show eosinophilia, myelofibrosis, and expansion of immature erythroid precursors.
Ge T, Kuang D, Mao X, Liu S, Wang J, Ao Q, Xiao M.   +6 more
europepmc   +2 more sources

Severe Folate Deficiency Mimicking Myelodysplastic Syndrome/Acute Myeloid Leukemia: A Case Report. [PDF]

Case Rep Hematol
Folate deficiency is common and often asymptomatic, but severe cases can cause megaloblastic anemia. Rarely, it presents with pancytopenia and bone marrow changes resembling myelodysplastic syndrome/neoplasm (MDS) and/or acute myeloid leukemia (AML), complicating diagnosis and management. We present a case of a patient with severe folate deficiency, in
Potter S, Williams M, Hanley TM.
europepmc   +2 more sources

Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study. [PDF]

J Pathol Clin Res
Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Jenei A, Kajtár B, László T, Juratli HA, Vida L, Szepesi Á, Mózes R, Timár B, Halter J, Dirnhofer S, Tzankov A.   +10 more
europepmc   +2 more sources

Could Old-School Erythroleukaemia be Back in Style Thanks to <i>TP53</i>? [PDF]

EJHaem
eJHaem, Volume 6, Issue 4, August 2025.
Rieu JB, Canali A, Comont T, Ousset L, De Mas V.   +4 more
europepmc   +2 more sources

Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis. [PDF]

Hemasphere
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
El Hoss S, Lizarralde-Iragorri MA, Maciel TT, Hermine O.   +3 more
europepmc   +2 more sources

Genetic analysis of primary lung interdigitating dendritic cell sarcomas. [PDF]

J Pathol
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Ermakov MS, Filipe JF, Eidenhammer S, Ott G, Halbwedl I, Kashofer K, Popper H.   +6 more
europepmc   +2 more sources

Preserved cellular immunity in smoldering acute leukemia [PDF]

, 1976
"Smoldering acute leukemia", a variant of acute myelogenous leukemia, has been recognized with frequent incidence in recent years. This is chracterized by benign clinical course, poor physical findings, leukopenia and mild anemia in the ...
Hironobu Toki, Toki, Hironobu
core   +1 more source

Identification of cooperating genetic events in acute leukemia [PDF]

, 2009
The genetic alterations associated with acute leukemia can be divided into two functional groups. The class I mutations enhance cellular proliferation and survival by constitutive activation of mainly protein tyrosine kinases signaling pathways.
Liu, Ting
core   +1 more source

Targeting the MLL complex in acute leukemia [PDF]

, 2014
Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core   +1 more source

Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid Leukemia [PDF]

, 2009
Background Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute myeloid leukemias (AML), and in mixed phenotype acute leukemias in infancy - a disease with extremely poor prognosis.
Meyer, Claus, Röhrs, Sonja, Claus Meyer, Slany, Robert, Scherr, Michaela, Wilhelm G Dirks, Meyer Claus, Marschalek Rolf, Dirks, Wilhelm G., Quentmeier Hilmar, Wallace, Andrew, Scherr Michaela, Sonja Röhrs, Hans G Drexler, Drexler, Hans Günter, Quentmeier, Hilmar, Dirks Wilhelm G, Marschalek, Rolf (Prof. Dr.), Robert Slany, Drexler Hans G, Rolf Marschalek, Slany Robert, Andrew Wallace, Wallace Andrew, Röhrs Sonja, Michaela Scherr, Hilmar Quentmeier   +26 more
core   +1 more source