Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study. [PDF]
Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Jenei A +10 more
europepmc +2 more sources
Could Old-School Erythroleukaemia be Back in Style Thanks to <i>TP53</i>? [PDF]
eJHaem, Volume 6, Issue 4, August 2025.
Rieu JB +4 more
europepmc +2 more sources
Masking as Myelofibrosis: A Case of Tp53 Mutated Acute Erythroid Leukemia Presenting With Pancytopenia and Bone Pain. [PDF]
Acute erythroid leukemia is a rare form of acute myeloid leukemia, comprising only 1% of myelogenous leukemia diagnoses. Presentations can vary and given its aggressive nature, prompt investigation and appropriate treatment are needed when suspicions arise. Here, we discuss a case of a 54‐year‐old male who initially presented with worsening fatigue and
Parker K, Cutrer RC.
europepmc +2 more sources
Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis. [PDF]
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
El Hoss S +3 more
europepmc +2 more sources
GRAVIS MYASTHENIA – ACUTE ERYTHROBLASTIC LEUKEMIA CORRELATION
Myasthenia Gravis is a chronic autoimmune neuromuscular disorder that is characterized by fluctuating weakness of the voluntary muscle groups. It occurs in all races, at any age (especially under 40 or over 60), both genders, with a prevalence of 20/100,000 population in the United States.
Angela Mirela Soare, Cezar Mihai Popescu
openaire +1 more source
Clinical studies on iron metabolism of erythroblasts in preleukemic stage [PDF]
The appearance of sideroblasts in hypoplastic anemia (HAl and acute myelocytic leukemia (AML), together with their sideroblastograms, was studied. Hematological studies on cases with type III sideroblast dominance by sideroblastograms produced the ...
Kimura, Ikuro +2 more
core +1 more source
HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer [PDF]
Background: HAGE protein is a known immunogenic cancer-specific antigen. Methods: The biological, prognostic and predictive values of HAGE expression was studied using immunohistochemistry in three cohorts of patients with BC (n=2147): early primary (EP ...
A G Pockley +48 more
core +3 more sources
Bullous pyoderma gangrenosum and myelodysplastic syndrome [PDF]
Pyoderma gangrenosum can present as a cutaneous manifestation of paraneoplastic syndromes. A case of bullous pyoderma gangrenosum associated with bicytopenia is described.
Almeida, Fernando Augusto De +7 more
core +4 more sources
Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia [PDF]
Regulation of erythropoiesis is achieved by integration of distinct signals. Among these, macrophages are emerging as erythropoietin-complementary regulators of erythroid development, particularly under stress conditions. We investigated the contribution
Abdel-Wahab, Omar +15 more
core +1 more source
MiR-148a inhibits angiogenesis by targeting ERBB3. [PDF]
MicroRNAs (miRNAs) play an important role in carcinogenesis in various solid cancers including breast cancer. Down-regulation of microRNA-148a (miR-148a) has been reported in certain cancer types.
Jiang, Bing-Hua +4 more
core +1 more source

