Results 21 to 30 of about 2,220 (157)

GRAVIS MYASTHENIA – ACUTE ERYTHROBLASTIC LEUKEMIA CORRELATION

Romanian Medical Journal, 2017
Myasthenia Gravis is a chronic autoimmune neuromuscular disorder that is characterized by fluctuating weakness of the voluntary muscle groups. It occurs in all races, at any age (especially under 40 or over 60), both genders, with a prevalence of 20/100,000 population in the United States.
Angela Mirela Soare, Cezar Mihai Popescu
openaire   +1 more source

Autopsy findings of acute erythroid leukemia

Autopsy and Case Reports, 2023
Acute erythroid leukemia (AEL) is an exceedingly uncommon but distinct hematological malignancy that shows neoplastic proliferation of erythroid precursors with maturation arrest and no significant myeloblasts.
Mayur Parkhi, Nabhajit Mallik, Deepesh Lad, Man Updesh Singh Sachdeva, Amanjit Bal, Pankaj Malhotra, Suvradeep Mitra   +6 more
doaj  

Trisomy 10 and acute myeloid leukemia

, 2002
We report the second case of trisomy 10 as the sole abnormality in acute erythroblastic leukemia (AML M6). Trisomy 10 is a rare recurring numerical chromosomal abnormality is probably linked to a myeloblast subset with CD7+ and CD33+ immunophenotype ...
Pagliuca, A, Czepulkowski, B, Mufti, G J, Powell, A R   +3 more
core   +1 more source

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Immunological classification of acute myeloblastic leukemias: relevance to patient outcome

, 2003
Immunophenotyping is a major tool to assign acute leukemia blast cells to the myeloid lineage. However, because of the large heterogeneity of myeloid-related lineages, no clinically relevant immunological classification of acute myeloblastic leukemia ...
Campos, L, Slimane, Fawzi Kara, Lecalvez, Geneviève, Falkenrodt, A, V Deneys, A Falkenrodt, Bernier, Michel, Faure, GC, Campos, Lydia, Garand, Richard, Maynadie, M, Bene, MC, R O Casasnovas, L Campos, M C Béné, M Bernier, M Maynadié, Casanovas, RO, Maynadié, Marc, Bernier, M, R Garand, Casasnovas, René Olivier, Faure, Gilbert, Béné, Marie-Christine, G C Faure, Falkenrodt, Annie, Garand, R., Lecalvez, G, F K Slimane, Deneys, Véronique, G Lecalvez, Slimane, FK   +31 more
core   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

Clinical and Statistical Studies on the Changes of the Clinical Pictures of Leukemia Part 1. On the Changes of the Clinical Pictures of Acute Leukemia in the Initial Stage [PDF]

, 1968
On 237 cases of acute leukemia admitted to our clinic from 1953 to 1965, the main symptoms and hematological findings in the initial stage were statistically evaluated.
Ishizaki, Masanobu
core  

High-resolution molecular allelokaryotyping identifies novel genomic alterations in acute promyelocytic leukemia (APL)

, 2010
Introduction: Experimental evidence obtained in transgenic mice revealed that PML-RARA is necessary but not sufficient for the development of APL, suggesting that additional genetic mutations are also required for its development.
Testoni, Nicoletta, Paolini, Stefania, Stefania Paolini, Candoni, Anna, Francesca Arruga, Emanuela Ottaviani, Giuseppe Saglio, LONETTI, ANNALISA, Pane, Fabrizio, Michela Rondoni, Francesco Lo Coco, Michele Baccarani, Anna Candoni, Messa, Francesca, Nicoletta Testoni, Hasan Syed Khizer, Saglio, Giuseppe, Giovanni Martinelli, IACOBUCCI, ILARIA, Daniela Cilloni, Papayannidis, Cristina, Fabrizio Pane, Viviana Guadagnuolo, Francesca Messa, Arruga, Francesca, GUADAGNUOLO, VIVIANA, Cilloni, Daniela, Annalisa Lonetti, Cristina Papayannidis, Rondoni, Michela, Baccarani, Michele, Martinelli, Giovanni, Khizer, Hasan Syed, Ottaviani, Emanuela, Ilaria Iacobucci, Coco, Francesco Lo   +35 more
core   +1 more source

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

HMGB3 promotes brain metastasis of lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism

Cancer Communications, Volume 45, Issue 12, Page 1676-1705, December 2025.
Abstract Background Brain metastasis, a leading cause of death in patients with lung adenocarcinoma (LUAD), arises from tumor cells adapting to the unique microenvironment of the brain through metabolic remodeling regulated by key oncogenes. Here, we aimed to determine the role of high mobility group protein box 3 (HMGB3) in regulating tumor cell ...
Huanhuan Cui, Yuechao Yang, Sen Li, Yan Hao, Mingtao Feng, Changshuai Zhou, Xin Chen, Yang Gao, Lei Chen, Xiaojun Wu, Weiguo Hu, Liangdong Li, Yiqun Cao   +12 more
wiley   +1 more source