Results 31 to 40 of about 3,733 (177)

An introspective update on the influence of miRNAs in breast carcinoma and neuroblastoma chemoresistance [PDF]

, 2014
Chemoresistance to conventional cytotoxic drugsmay occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence ...
Ayers, Duncan, Carta, Alessia, Chetcuti, Rachel   +2 more
core   +4 more sources

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Repair or destruction: an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis [PDF]

, 2017
Cellular differentiation, developmental processes, and environmental factors challenge the integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis, or proteostasis, involves folding and degradation of damaged proteins ...
Amerik, Anckar, Apaja, Arndt, Arndt, Aviram, Balch, Ballinger, Bar-Lavan, Barrott, Bartel, Bays, Becuwe, Behrends, Bengtson, Boban, Boban, Bodnar, Boomsma, Bordallo, Brandman, Brehme, Broersen, Buchner, Calderwood, Carra, Catlett, Choe, Christianson, Chu, Ciechanover, Ciocca, Ciryam, Commerford, Connell, Craig, Crippa, Crosas, Cuervo, Cuervo, Cyr, Dai, Davies, Defenouillere, Deng, Deyter, Donati, Douglas, Douglas, Dunker, Duttler, Ehrlich, Eisele, Ellis, Fan, Fang, Fang, Fang, Fang, Ferreira, Finley, Finley, Foresti, Fourie, Fredrickson, Gallagher, Gamerdinger, Gardner, Garrido, Goldberg, Guerriero, Guo, Han, Hartl, Hatakeyama, Heck, Hemmingsen, Hessa, Hettema, Higy, Hondele, Hondele, Hoppe, Iwata, Jana, Jego, Jiang, Jin, Joshi, Kahn, Kampinga, Kaplan, Katsogiannou, Kaushik, Kaushik, Keller, Kenyon, Kerscher, Kettern, Khmelinskii, Kim, Kitagawa, Koegl, Komander, Koren, Kraft, Kuhlbrodt, Kuhlbrodt, Kumar, Kuo, Kwon, Laba, Labbadia, Lakshmipathy, Lee, Lerch-Bader, Levine, Li, Li, Lopez, Lopez-Otin, MacGurn, Maier, Matsumura, Mattiroli, Maurer, McDonough, Meacham, Mehnert, Meng, Merz, Metzger, Min, Mishra, Mizushima, Morano, Morimoto, Morimoto, Morimoto, Morishima, Murata, Murata, Nahleh, Nillegoda, Nillegoda, Nillegoda, Park, Park, Paul, Petrucelli, Powers, Powers, Prasad, Qian, Ranford, Rape, Ravid, Rees, Roberts, Roberts, Rodina, Rodrigo-Brenni, Rosenbaum, Ruggiano, Russell, Rüb, Rüdiger, Saez, Saibil, Salminen, Samant, Schopf, Shahsavarani, Shao, Shiber, Shiga, Shin, Singh, Singh, Singh, Soss, Sowa, Spiechowicz, Stuttmann, Sulistio, Sultana, Summers, Sung, Swanson, Taipale, Takayama, Tasaki, Tasaki, Tawo, Taylor, Terman, Tzankov, Ulbricht, Urushitani, VanPelt, Venkatesh, Verma, Vilchez, Walther Dirk, Wang, Wang, Willhoft, Williams, Xie, Xu, Xu, Yonashiro, Yu, Zargari, Zhang, Zhang, Zhao, Zhao, Zhou, Zuehlke, Zuiderweg   +220 more
core   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

Ptk7-Deficient Mice Have Decreased Hematopoietic Stem Cell Pools as a Result of Deregulated Proliferation and Migration

, 2016
International audienceHematopoietic stem cells (HSCs) located in adult bone marrow or fetal liver in mammals produce all cells from the blood system. Atthe top of the hierarchy are long-term HSCs endowed with lifelong self-renewal and differentiation ...
Arcangeli, Marie-Laure, Aurrand-Lions, Michel, Bardin, Florence, Borg, Jean-Paul, de Grandis, Maria, Giordano, Marilyn, Lembo, Frédérique, Lhoumeau, Anne-Catherine, Marchetto, Sylvie, Orsoni, Jean-Christophe   +9 more
core   +3 more sources

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties [PDF]

, 2013
Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl transfer, termed pseudokinases, have emerged as important signalling domains across all kingdoms of life.
Babon, Jeffrey J., Bailey, Fiona P., Chen, Kelan, Daly, Roger J., Elowe, Sabine, Eyers, Patrick A., Fukuda, Koichi, Gee, Christine L., Hammaren, Henrik, Jura, Natalia, Liu, Ling, Lucet, Isabelle S., Manning, Gerard, Mudgett, Mary Beth, Murphy, James M., Nimchuk, Zachary, Qin, Jun, Reese, Michael L., Silvennoinen, Olli, Tripaydonis, Anne, Ungureanu, Daniela, Varghese, Leila N., Young, Samuel N., Zhang, Qingwei   +23 more
core   +1 more source

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

Neurofibromatosis 2011: a report of the Children’s Tumor Foundation Annual Meeting [PDF]

, 2011
The 2011 annual meeting of the Children\u27s Tumor Foundation, the annual gathering of the neurofibromatosis (NF) research and clinical communities, was attended by 330 participants who discussed integration of new signaling pathways into NF research ...
Alison C. Lloyd, Anat Stemmer-Rachamimov, C. Oliver Hanemann, D. Gareth Evans, David Ingram, David Viskochil, Debra A. Mayes, Duojia Pan, Dusica Babovic-Vuksanovic, Filippo Giancotti, Helen Morrison, Karen Cichowski, Kathryn North, Kim Hunter-Schaedle, Ludwine Messiaen, Margret R. Wallace, Maria T. Acosta, Meena Upadhyaya, Michel Kalamarides, Nancy Ratner, Olli Carpen, Roger Packer   +21 more
core   +3 more sources

HMGB3 promotes brain metastasis of lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism

Cancer Communications, Volume 45, Issue 12, Page 1676-1705, December 2025.
Abstract Background Brain metastasis, a leading cause of death in patients with lung adenocarcinoma (LUAD), arises from tumor cells adapting to the unique microenvironment of the brain through metabolic remodeling regulated by key oncogenes. Here, we aimed to determine the role of high mobility group protein box 3 (HMGB3) in regulating tumor cell ...
Huanhuan Cui, Yuechao Yang, Sen Li, Yan Hao, Mingtao Feng, Changshuai Zhou, Xin Chen, Yang Gao, Lei Chen, Xiaojun Wu, Weiguo Hu, Liangdong Li, Yiqun Cao   +12 more
wiley   +1 more source

Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib. [PDF]

, 2018
Many cancer therapies produce toxic side effects whose molecular mechanisms await full elucidation. The most feared and studied side effect of chemotherapeutic drugs is cardiotoxicity.
Berrino, L, De Angelis, A, Ferraro, E, Gorini, S, Malara, N, Rosano, G   +5 more
core   +4 more sources