Off‐target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
British Journal of Pharmacology, Volume 181, Issue 20, Page 3799-3818, October 2024.Abstract Statins are one of the most important classes of drugs. In this analytical review, we elucidate the intricate molecular mechanisms and toxicological rationale regarding both the on‐ (targeting 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase [HMGCR]) and off‐target effects of statins.
Francisco Alejandro Lagunas‐Rangel +7 more
wiley +1 more source
Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway [PDF]
, 2012 [Abstract] Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis.
Antón-Aparicio, Luis M. +4 more
core +3 more sources
Antibody–drug conjugates in cancer therapy: mechanisms and clinical studies
MedComm, Volume 5, Issue 8, August 2024.The antibodies of ADCs bind to antigens on the cell surface, forming ADC–antigen complexes. These complexes are subsequently internalized into lysosomes via receptor‐mediated endocytosis. Once inside the lysosomes, the ADCs can be degraded by enzymes or the acidic environment, releasing cytotoxic payloads that can disrupt DNA or inhibit microtubule ...
Jun He +4 more
wiley +1 more source
A rare type of acute leukemia in peripheral blood smear
Hematology, Transfusion and Cell Therapy, 2023 Edwin Uriel Suárez +2 more
doaj +1 more source
Sialic acid in the regulation of blood cell production, differentiation and turnover
Immunology, Volume 172, Issue 4, Page 517-532, August 2024.Sialylation is a post‐translational glycosylation modification utilized in haematopoiesis to meet the dynamic needs of the organism by enforcing rapid changes in availability of lineage‐specific cell types. Though long thought to be generated only cell‐autonomously within the intracellular ER‐Golgi secretory apparatus, emerging data also demonstrate ...
Eric Edward Irons +2 more
wiley +1 more source
Food Frontiers, Volume 5, Issue 4, Page 1749-1764, July 2024.A combination of transcriptomic and proteomic analysis was used to investigate the effect of a particular sRNA known as Salmonella adhesive‐associated sRNA (SaaS) on the intestinal damage induced by Salmonella. SaaS was found to strengthen Salmonella's invasion in the colon by specifically targeting PGLYRP1, TfR1, and HSD11B2 to suppress the host's ...
Lin‐lin Cai +5 more
wiley +1 more source
Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells [PDF]
, 2005 Background Cancer prevention trials using different types of antioxidant supplements have been carried out at several occasions and one of the investigated compounds has been the antioxidant N-acetyl-L-cysteine (NAC).
Anna C Gustafsson +86 more
core +1 more source
Pathophysiology of myelodyspoastic syndrome – network between bone marrow and nervus system [PDF]
, 2013 科学研究費助成事業(学術研究助成基金助成金)研究成果報告書：挑戦的萌芽研究2011-2012課題番号 ...
Chiba Shigeru, 千葉 滋
core
Exploring the interdependencies of research funders in the UK [PDF]
, 2014 Investment in medical research is vital to the continuing improvement of the UK's health and wealth. It is through research that we expand our understanding of disease and develop new treatments for patients.
Crane, P +13 more
core +1 more source
Rb and hematopoiesis: stem cells to anemia [PDF]
, 2008 The retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of studies have described its role in various ...
Carl R Walkley +2 more
core +1 more source