Genetic modification and effector functions of natural killer cells in acute myeloid leukemia [PDF]
, 2006 Acute myeloid leukemia (AML) is characterized by a poor long-term outcome in the majority of patients following conventional treatment with chemotherapy.
Siegler, Uwe
core +1 more source
The PML-RAR alpha transcript in long-term follow-up of acute promyelocytic leukemia patients [PDF]
, 2001 Background and Objectives. Detection of PML-RAR alpha transcripts by RT-PCR is now established as a rapid and sensitive method for diagnosis of acute promyelocytic leukemia (APL), Although the majority of patients in longterm clinical remission are ...
Gameiro, P +11 more
core
Acta haematologica Polonica, 1993 A retrospective analysis of the relation of relapses and anaemias to the frequency of micronucleated erythroblasts in bone marrow smear in 140 children with acute lymphoblastic leukaemia after BFM and Memphis schemes of therapy was carried out. The anaemias correlated with the frequency of micronucleated erythroblasts in statistically significant ...
K, Rytwiński +3 more
openaire +1 more source
Death Rate Higher in Minorities with Acute Leukemia
, 2011 Blacks and Hispanics have fewer cases of acute leukemia compared to whites but they die at a substantially higher rate, according to study results presented at the Fourth AACR Conference on The Science of Cancer Health Disparities, held here Sept. 18-21,
AACR, Communications Staff
core +1 more source
Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells [PDF]
, 2004 The granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R binds to the GM-CSF receptor complex with low affinity and acts as a competitive antagonist.
Jakupovic, I. +3 more
core
ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia [PDF]
, 2014 Background: Acute leukemia in early age (EAL) is characterized by acquired genetic alterations such as MLL rearrangements (MLL-r). The aim of this case-controlled study was to investigate whether single nucleotide polymorphisms (SNPs) of IKZF1, ARID5B ...
Andrade, Camilla +18 more
core +2 more sources
, 2018 Deferasirox (DFX), in addition to its iron-chelation property, has marked anti-proliferative effects on cancer cells. However, the activity and mechanism by which DFX inhibits acute myeloid leukemia (AML) cells remain to be elucidated.
Huang, Yu-Ting +8 more
core +1 more source
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors [PDF]
, 2002 FLT3 mutations, either internal tandem duplications (ITDs) or aspartate residue 835 (D835) point mutations, are present in approximately one third of patients with acute myeloid leukemia (AML) and have been associated with an increased relapse rate.
Kottaridis, P.D. +5 more
core
, 2017 Let-7a-3 transcribes the miRNA let-7a, of which the expression is dysregulated in cancer. We evaluated the significance of let-7a-3 gene methylation in patients with de novo acute myeloid leukemia (AML).
Ko, Ya-Chen;Fang, Woei-Horng;Lin, Tsung-Chin;Hou, Hsin-An;Chen, Chien-Yuan;Tien, Hwei-Fang;Lin, Liang-In +1 more
core +1 more source
In vitro and in vivo analysis of human cell-based immunotherapies for acute myeloid leukemia [PDF]
, 2011 Conventional cancer therapies like surgery, radiation and chemotherapy help to eliminate primary tumor masses but often fail to eradicate disseminated tumor cells.
Spranger, Stefani
core +1 more source