Results 41 to 50 of about 3,733 (177)

Pure Erythroleukemia (Variant Acute Myeloid Leukemia-vAML-M6) with Deletion of Chromosome 20, Mainly Presenting as Late Erythroblasts, a Unique Case Report with Review of Literature [PDF]

Indian Journal of Hematology and Blood Transfusion, 2012
Acute erythroleukemia is characterized by a predominant immature erythroid population and accounts for approximately 2-5 % of all cases of acute leukemia. Two subtypes are recognized based on the presence or absence of a significant myeloid component: erythroleukemia and pure erythroid leukemia.
Javid, Rasool, Sajad, Geelani, , Khursheed, , Yasir, Mohd Suhail, Lone, Mohd, Shaban   +5 more
openaire   +2 more sources

The Role of WT1 in Embryonic Development and Normal Organ Homeostasis. [PDF]

, 2016
The Wilms' tumor suppressor gene 1 (Wt1) is critically involved in a number of developmental processes in vertebrates, including cell differentiation, control of the epithelial/mesenchymal phenotype, proliferation, and apoptosis.
Muñoz-Chapuli, Ramon, Wilm, Bettina
core   +1 more source

The bone marrow niche landscape: a journey through aging, extrinsic and intrinsic stressors in the haemopoietic milieu [PDF]

, 2022
Inflammation and its effects in the bone marrow microenvironment represent a paradigmatic condition in which the hematopoietic niche and the immune systems, thought to properly sustain blood cell production and distinguish between friend and foe, can ...
Melaccio, Assunta, Ria, Roberto, Solimando, Antonio Giovanni, Vacca, Angelo   +3 more
core   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

International Journal of Cancer, Volume 157, Issue 2, Page 371-383, 15 July 2025.
What's new? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita, Chiara Maria Mazzanti, Francesca Lessi, Caterina Marchiò, Cristian Scatena, Michele Menicagli, Matteo Ghilli, Manuela Roncella, Antonio Giuseppe Naccarato, Anna Sapino, Jacob Hochman, Mauro Pistello, Generoso Bevilacqua   +12 more
wiley   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, Volume 12, Issue 20, May 29, 2025.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer [PDF]

, 2014
Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment.
Aburatani, Ahlquist, Arlinghaus, Barasch, Barresi, Barresi, Barresi, Barresi, Batra, Birrer, Borregaard, Borregaard, Borregaard, Bowtell, Braun, Buemi, Buemi, Canipari, Cheah, Chinnaiyan, Cho, Cooperman, Cordon-Cardo, Cosgrove, Cowland, de la Chapelle, Delwel, Di Carlo, El-Omar, Eschrich, Fenoglio-Preiser, Flower, Friedl, Frühbeck, García-Valdecasas, García-Valdecasas, Ghosh, Godley, Gould, Gould, Green, Hahn, Henshall, Hsieh, Hsieh, Huang, Hunt, Hynes, Jain, Katagiri, Kern, Khan, Khandan, Kim, Kim, Kjeldsen, Kovacs, Krishnan, Kumamoto, Langdon, Lee, Lemoine, Leonardi, Li, Li, Libermann, Lin, Mak, Matthews, McCubrey, Mei, Milella, Morel, Moses, Moses, Moses, Moses, Moses, Murty, Neilands, Neri, Ostrowski, Paley, Pesatori, Popescu, Raul, Rice, Ringel, Schlemper, Selby, Shen, Shurtleff, Strong, Strong, Strong, Sukhatme, Syrjänen, Tao, Taylor, Thun, Turhan, Verspaget, Vogel, Von Hoff, Wang, Wang, Waxman, Xu, Xu, Xu, Yan, Young, Yu, Yu, Zaoui, Zeng, Zhang, Zografos   +117 more
core   +2 more sources

Inter‐Ethnic Differences in the Efficacy and Safety of Tyrosine Kinase Inhibitors Used in Oncology: Insights From Phase 3 Clinical Trials

Clinical and Translational Science, Volume 18, Issue 5, May 2025.
ABSTRACT Differences in the efficacy and safety of tyrosine kinase inhibitors (TKIs) have been observed across ethnic/ancestry subpopulations (previously reviewed to 2017). With an expanding number of TKIs approved since that time, an updated review of TKI response across ethnic/ancestry subpopulations in Phase 3 TKI clinical trials was conducted.
Nicki M. Kyriacou, Annette S. Gross, Andrew J. McLachlan   +2 more
wiley   +1 more source

Analyzing the role of ferroptosis in ribosome‐related bone marrow failure disorders: From pathophysiology to potential pharmacological exploitation

IUBMB Life, Volume 76, Issue 12, Page 1011-1034, December 2024.
Abstract Within the last decade, the scientific community has witnessed the importance of ferroptosis as a novel cascade of molecular events leading to cellular decisions of death distinct from apoptosis and other known forms of cell death. Notably, such non‐ apoptotic and iron‐dependent regulated cell death has been found to be intricately linked to ...
Aliki Papadimitriou‐Tsantarliotou, Chrysostomos Avgeros, Maria Konstantinidou, Ioannis S. Vizirianakis   +3 more
wiley   +1 more source

Transcriptional Assessment by Microarray Analysis and Large-Scale Meta-analysis of the Metabolic Capacity of Cardiac and Skeletal Muscle Tissues to Cope With Reduced Nutrient Availability in Gilthead Sea Bream (Sparus aurata L.) [PDF]

, 2017
The effects of nutrient availability on the transcriptome of cardiac and skeletal muscle tissues were assessed in juvenile gilthead sea bream fed with a standard diet at two feeding levels: (1) full ration size and (2) 70 % satiation followed by a ...
Baron, Daniel, Calduch-Giner, Josep A., Crespo, Diego, Echasseriau, Yann, Planas, Josep V., Prunet, Patrick, Pérez-Sánchez, Jaume   +6 more
core   +1 more source