Results 41 to 50 of about 2,220 (157)

Off‐target effects of statins: molecular mechanisms, side effects and the emerging role of kinases

British Journal of Pharmacology, Volume 181, Issue 20, Page 3799-3818, October 2024.
Abstract Statins are one of the most important classes of drugs. In this analytical review, we elucidate the intricate molecular mechanisms and toxicological rationale regarding both the on‐ (targeting 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase [HMGCR]) and off‐target effects of statins.
Francisco Alejandro Lagunas‐Rangel, Edgars Liepinsh, Robert Fredriksson, Ahmed M. Alsehli, Michael J. Williams, Maija Dambrova, Jörgen Jönsson, Helgi B. Schiöth   +7 more
wiley   +1 more source

A rare type of acute leukemia in peripheral blood smear

Hematology, Transfusion and Cell Therapy, 2023
Edwin Uriel Suárez, María José Cortti, Carlos Soto de Ozaeta   +2 more
doaj   +1 more source

Antibody–drug conjugates in cancer therapy: mechanisms and clinical studies

MedComm, Volume 5, Issue 8, August 2024.
The antibodies of ADCs bind to antigens on the cell surface, forming ADC–antigen complexes. These complexes are subsequently internalized into lysosomes via receptor‐mediated endocytosis. Once inside the lysosomes, the ADCs can be degraded by enzymes or the acidic environment, releasing cytotoxic payloads that can disrupt DNA or inhibit microtubule ...
Jun He, Xianghua Zeng, Chunmei Wang, Enwen Wang, Yongsheng Li   +4 more
wiley   +1 more source

Modelling Down Syndrome leukaemia using transchromosomic ES cell lines.

, 2009
PhDAMKL (acute megakaryoblastic leukaemia) accounts for at least 50% of all cases of acute myeloid leukaemia (AML) associated with Down Syndrome (DS). Every tenth neonate with DS develops Transient Myeloproliferative Disorder (TMD), a self-regressing
De Vita, Serena
core  

Characterization of cellular dynamics during bone marrow regeneration in normal and leukemic states [PDF]

, 2023
Bone marrow (BM) regeneration is needed to overcome myelosuppression during cancer therapy-induced injury to maximize the dose and effectiveness of tumor targeting therapy.
Zhao, Xueli
core  

Sialic acid in the regulation of blood cell production, differentiation and turnover

Immunology, Volume 172, Issue 4, Page 517-532, August 2024.
Sialylation is a post‐translational glycosylation modification utilized in haematopoiesis to meet the dynamic needs of the organism by enforcing rapid changes in availability of lineage‐specific cell types. Though long thought to be generated only cell‐autonomously within the intracellular ER‐Golgi secretory apparatus, emerging data also demonstrate ...
Eric Edward Irons, Sajina Gc, Joseph T. Y. Lau   +2 more
wiley   +1 more source

Identification of downstream target genes of the t-cell oncoprotein HOX11 by global gene expression profiling

, 2004
HOX11 is a homeodomain transcription factor that has been implicated in leukaemic transformation associated with T-cell acute lymphoblastic leukaemia (T-ALL).
Dixon, Darcelle Natalie
core  

Multi‐omics approaches reveal inflammatory response and intestinal damage mediated by sRNA SaaS during Salmonella invasion in mice

Food Frontiers, Volume 5, Issue 4, Page 1749-1764, July 2024.
A combination of transcriptomic and proteomic analysis was used to investigate the effect of a particular sRNA known as Salmonella adhesive‐associated sRNA (SaaS) on the intestinal damage induced by Salmonella. SaaS was found to strengthen Salmonella's invasion in the colon by specifically targeting PGLYRP1, TfR1, and HSD11B2 to suppress the host's ...
Lin‐lin Cai, Yun‐ting Xie, Hai‐jing Hu, Xing‐lian Xu, Hu‐hu Wang, Guang‐hong Zhou   +5 more
wiley   +1 more source

Badanie chimeryzmu specyficznego liniowo po allogenicznym przeszczepieniu komórek macierzystych

, 2014
IntroductionDonor lineage-specific chimerism of hematopoietic cells enables very precise monitoring of engraftment in selected cell lines after allogeneic stem cell transplantation (allo-SCT).Materials and methodsThe study group consisted of 12 acute ...
Dzierżak-Mietła, Monika; Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Head: prof. dr hab. n. med. Sławomira Kyrcz-Krzemień, Katowice, Poland, Białas, Krzysztof; Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Head: prof. dr hab. n. med. Sławomira Kyrcz-Krzemień, Katowice, Poland, Zielińska, Patrycja, Koclęga, Anna; Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Head: prof. dr hab. n. med. Sławomira Kyrcz-Krzemień, Katowice, Poland, Markiewicz, Mirosław; Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Head: prof. dr hab. n. med. Sławomira Kyrcz-Krzemień, Katowice, Poland, Jagoda, Krystyna; Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Head: prof. dr hab. n. med. Sławomira Kyrcz-Krzemień, Katowice, Poland, Kopera, Małgorzata; Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Head: prof. dr hab. n. med. Sławomira Kyrcz-Krzemień, Katowice, Poland, Karolczyk, Agnieszka; Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Head: prof. dr hab. n. med. Sławomira Kyrcz-Krzemień, Katowice, Poland, Kyrcz-Krzemień, Sławomira; Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Head: prof. dr hab. n. med. Sławomira Kyrcz-Krzemień, Katowice, Poland   +8 more
core   +1 more source

Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies

, 2016
Recently our group and others have identified DDX41 mutations both as germ line and acquired somatic mutations in families with multiple cases of late onset myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML), suggesting that DDX41 acts as
Suthers, G.K., Yong, A., Weinel, L.M., Lee, Y., Rafidi, G., Feng, J., Phillips, K., Altree, M., Poplawski, N., D'Andrea, R.J., Jaensch, L., Fine, M., Schreiber, A.W., Lewis, I.D., Lee, M.K., Chong, C.E., Lewinsohn, M., Phung, C., et al., Brown, A.L., Babic, M.   +20 more
core   +1 more source