Results 51 to 60 of about 10,434 (197)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Generation of K562/ADM cells.

, 2013
(A) K562/ADM cells were established after exposure of K562 cells to ADM. MDR1 expression in parental and drug-treated K562 cells was normalized to the GAPDH housekeeping gene. (B) FACS analysis of K562 and K562/ADM cells stained with P-gp antibody.
Stephen J. Ohms (489675), Yiqiao Hu (392239), Jun Y. Fan (489677), M. Frances Shannon (6653), Zhiyong Mao (489676), Yan Xu (14594), Qiao Wang (174321), Guangming Gong (263029), Zhen Li (49109)   +8 more
core   +1 more source

TAM family kinases are potential candidate targets for therapeutic intervention in chronic myeloid leukemia

Discover Oncology
Background Chronic Myeloid Leukemia (CML) is a hematologic disorder depicted by BCR::ABL1 translocation; a constitutively active tyrosine kinase (TK) and a hallmark of CML. Kinase domain mutations and the activation of alternative signaling pathways lead
Maryam Yousaf, Khadija Arif, Dilawar Khan   +2 more
doaj   +1 more source

Induction of Apoptosis, G0/G1 Phase Arrest and Microtubule Disassembly in K562 Leukemia Cells by Mere15, a Novel Polypeptide from Meretrix meretrix Linnaeus

Marine Drugs, 2012
Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells.
Xiukun Lin, Ning Wu, Linyou Cheng, Jin Zhao, Haizhou Liu, Lin Xiao, Cuicui Wang, Xiangzhong Zhao, Ming Liu   +8 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

K562 cells and stiffened K562 cells separation.

, 2013
(A) Flow cytometry analyses of the initial mixture of cells and the cells collected at the stiff and soft outlets show an enrichment of both cell types at the stiff and soft outlet respectively. 4% formaldehyde treated K562 cells (E =  kPa) were enriched
Rebecca Byler (471479), Wenbin Mao (471478), Krishna Patel (471480), Caitlin Henegar (471481), Todd Sulchek (143213), Alexander Alexeev (471482), Gonghao Wang (471477)   +6 more
core   +1 more source

Asperuloside regulates the proliferation, apoptosis, and differentiation of chronic myeloid leukemia cell line K562 through the RAS/MEK/ERK pathway

Heliyon
Context: Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disease caused by excessive proliferation and abnormal differentiation of hematopoietic stem cells.
Bingjie Zhao, Hong Che, Linlin Li, Lian Hu, Wenjing Yi, Li Xiao, Songshan Liu, Zhufa Hou   +7 more
doaj   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Mn-Zn ferrite nanoparticles inducing ferroptosis to reverse the resistance in CML cells

Journal of Translational Medicine
Background Chronic myeloid leukemia (CML) is a malignant clonal disease of hematopoietic stem cells driven by the BCR-ABL fusion gene. Although tyrosine kinase inhibitors (TKIs) serve as targeted therapies, drug resistance remains one of the key ...
Miao Zhu, Yanqian Zhao, Li Xu, Mei Sun, Yuxiang Sun   +4 more
doaj   +1 more source

Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance.

PLoS ONE, 2013
Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump to reduce the intracellular concentration of ...
Yan Xu, Stephen J Ohms, Zhen Li, Qiao Wang, Guangming Gong, Yiqiao Hu, Zhiyong Mao, M Frances Shannon, Jun Y Fan   +8 more
doaj   +1 more source