Results 71 to 80 of about 10,434 (197)

K562/ABCB1 and K562/ABCG2 cells exhibit collateral sensitivity to

, 2013
quizartinib. K562, K562/ABCB1 and K562/ABCG2 cells were plated in the presence of quizartinib in increasing concentrations for 96 hours and viable cells were measured using the WST-1 assay.
Jasjeet Bhullar (445431), Suneet Shukla (401303), Suresh V. Ambudkar (223101), Mariola Sadowska (445434), Karthika Natarajan (445432), Maria R. Baer (113955), Trevor J. Mathias (445433)   +6 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Investigação dos mecanismos de transdução de sinais envolvidos na apoptose induzida pelas chalconas sintéticas derivadas da 2, 4,5-trimetoxiacetofenona e do 2',4',5'-trimetoxibenzaldeído em leucemias agudas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaAs leucemias constituem um grupo heterogêneo de neoplasias malignas decorrentes da proliferação clonal de células ...
Costa, Aline
core  

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines

Acta Pharmaceutica, 2019
Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononu-clear cells (PBMC ...
Sabran Affidah, Kumolosasi Endang, Jantan Ibrahim   +2 more
doaj   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

PH II-7 induces S phase cell cycle arrest in K562 and K562/A02 cells.

, 2012
(A) PH II-7 induces cell cycle S phase arrest in a concentration-dependent manner in K562 and K562/A02 cells, the cells were treated with the indicated concentrations of PH II-7 for 24 hours.
Yunhui Hu (179592), Caiyun Wang (179623), Yinliang Xie (179616), Yingdai Gao (179630), Juanni Liu (179603), Yaohong Tan (179588), Yuan Zhou (179597), Jianxiang Wang (179637), Chunzheng Yang (179644), Xin Cheng (179584), Tao Cheng (131540), Hua Miao (179651), Ye Su (179577), Dongsheng Xiong (179646), Yuanfu Xu (179609)   +14 more
core   +1 more source

Genome-Wide CRISPR Screen Reveals Cancer Cell Resistance to NK Cells Induced by NK-Derived IFN-γ

Frontiers in Immunology, 2019
The anti-leukemia activity of NK cells helps prevent relapse during hematopoietic stem cell transplantation (HSCT) in leukemia patients. However, the factors that determine the sensitivity or resistance of leukemia cells in the context of NK-mediated ...
Xiaoxuan Zhuang, Daniel P. Veltri, Eric O. Long   +2 more
doaj   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Comparative proteomic analysis of differentially expressed proteins between K562 and K562/ADM cells

Chinese Medical Journal, 2008
Multidrug resistance to chemotherapeutic agents is an important clinical problem during the treatment of leukemia. The resistance process is multifactorial. To realize the total factors involved in multidrug resistance, we analyzed the differentially expressed proteins of K562 and K562/ADM cells and we investigated one of the up-regulated proteins ...
Shao-hua, Shen, Long-jun, Gu, Pei-qing, Liu, Xin, Ye, Wei-shan, Chang, Ben-shang, Li   +5 more
openaire   +2 more sources