Results 91 to 100 of about 75,344 (250)

Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines

Acta Pharmaceutica, 2019
Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononu-clear cells (PBMC ...
Sabran Affidah, Kumolosasi Endang, Jantan Ibrahim   +2 more
doaj   +1 more source

Dengue virus infection mediates HMGB1 release from monocytes involving PCAF acetylase complex and induces vascular leakage in endothelial cells.

PLoS ONE, 2012
High mobility group box 1 (HMGB1) protein is released from cells as a pro-inflammatory cytokine in response to an injury or infection. During dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), a number of pro-inflammatory cytokines are released,
Siew Pei Ong, Ling Min Lee, Yew Fai Ivan Leong, Mah Lee Ng, Justin Jang Hann Chu   +4 more
doaj   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis

Hematology
Background Imatinib (IM) is the primary treatment for patients with chronic-phase CML (CML-CP). However, an increasing number of CML-CP patients have developed resistance to IM.
Yaqin Jiang, Shishan Xiao, Shengwen Huang, Xuemei Zhao, Siruiyun Ding, Qianqian Huang, Wei Xiao, Zhe Li, Hongqian Zhu   +8 more
doaj   +1 more source

Dual gene activation and knockout screen reveals directional dependencies in genetic networks. [PDF]

, 2018
Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins
Biton, Anne, Blau, James A, Boettcher, Michael, Fu, Haian, Kampmann, Martin, Markegard, Evan, McCormick, Frank, McManus, Michael T, Mo, Xiulei, Tian, Ruilin, Wagner, Ryan T, Wu, David, Zaitlen, Noah   +12 more
core   +2 more sources

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Effect of interaction of magnetic nanoparticles of Fe3O4 and artesunate on apoptosis of K562 cells

International Journal of Nanomedicine, 2011
Ying Wang1, Yuxiang Han1, Yingying Yang1, Jingci Yang1, Xiaonan Guo1, Jingnan Zhang1, Ling Pan1, Guohua Xia2, Baoan Chen21Department of Hematology, the 2nd Hospital of Hebei Medical University, People’s Republic of China; 2Department of ...
Wang Y, Han Y, Yang Y, Yang J, Guo X, Zhang J, Pan L, Xia G, Chen B   +8 more
doaj  

FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells

Frontiers in Oncology, 2020
The cell-microenvironment communication is essential for homing of hematopoietic stem cells in stromal niches. Recent evidences support the involvement of epithelial-to-mesenchymal (EMT) process in hematopoietic stem cell homeostasis as well as in ...
Roberta Chirillo, Ilenia Aversa, Anna Di Vito, Alessandro Salatino, Anna Martina Battaglia, Alessandro Sacco, Maddalena Adriana Di Sanzo, Maria Concetta Faniello, Maria Concetta Faniello, Barbara Quaresima, Camillo Palmieri, Flavia Biamonte, Flavia Biamonte, Francesco Costanzo, Francesco Costanzo   +14 more
doaj   +1 more source

The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors [PDF]

, 2014
Chronic myeloid leukemia (CML) is initiated and maintained by the tyrosine kinase BCR-ABL which activates a number of signal transduction pathways, including PI3K/AKT signaling and consequently inactivates FOXO transcription factors.
Bhatia, Birkenkamp, Breitling, Bruennert, Brunet, Burgering, Chomel, Chu, Copland, Corbin, Druker, Duy, Essafi, Fernandez de Mattos, Ghaffari, Goldman, Graham, Hamilton, Hurtz, Ito, Jorgensen, Kikuchi, Komatsu, Koschmieder, Mahon, Matsumoto, Miyamoto, Naka, Pellicano, Pellicano, Pellicano, Ross, Ross, Rowley, Sarbassov, Skorski, Tothova, Tothova, Trotman   +38 more
core   +2 more sources

WT1 regulates cyclin�A1 expression in K562�cells

Oncology Reports, 2019
The restricted expression of Wilms tumor 1 (WT1) and cyclin A1 (CCNA1) in normal tissues, as opposed to their abnormal expression in leukemia demonstrates the applicability of WT1 and CCNA1 as cancer antigens for immunotherapy, and as markers for prognosis and relapse.
Sony, Pandey, Mustafa, Moazam, Nirmala, Ghimirey, Steven J, Kuerbitz, Gail C, Fraizer   +4 more
openaire   +3 more sources