Results 91 to 100 of about 10,434 (197)
T Cell Heterogeneity Shaped by Alternative Splicing Predicts Prognosis in Hepatocellular Carcinoma
Cancer Science, EarlyView.T cell‐specific alternative splicing events shape T cell heterogeneity in HCC. Single‐cell analysis identified two splicing‐defined T cell subpopulations with distinct functional profiles. Subpopulation‐associated splicing events were used to construct a prognostic model predicting patient survival.
Xiaohui Peng +11 more
wiley +1 more source
TOP2α/170 mRNA and protein levels in K562, drug resistant K/VP.5, and K562/SSedit-2 cells.
, 2022 (A) qPCR experiments were performed utilizing K562, K/VP.5, K562/SSedit-1 and K562/SSedit-2 cDNAs and a TaqMan hydrolysis assay specific for TOP2α/170 (E19/E20) mRNAs.
Victor A. Hernandez (12647320) +5 more
core +1 more source
HematologyBackground Imatinib (IM) is the primary treatment for patients with chronic-phase CML (CML-CP). However, an increasing number of CML-CP patients have developed resistance to IM.
Yaqin Jiang +8 more
doaj +1 more source
Frontiers in Oncology, 2020 The cell-microenvironment communication is essential for homing of hematopoietic stem cells in stromal niches. Recent evidences support the involvement of epithelial-to-mesenchymal (EMT) process in hematopoietic stem cell homeostasis as well as in ...
Roberta Chirillo +14 more
doaj +1 more source
Blocking SETD2 Enhances the Therapeutic Efficiency of Menin Inhibitor in MLL‐Fusion Leukemia
Cancer Science, EarlyView.Combined SETD2 and menin inhibitors make synergistic effects against MLL‐fusion leukemia; the combination therapy reduces the expression of target genes through blocking transcription elongation and initiation. ABSTRACT During transcriptional elongation, the histone methyltransferase SETD2 binds to RNA polymerase II and deposits trimethylation marks at
Anpei Li +10 more
wiley +1 more source
Regulation of gene expression by PH II-7 in K562 and K562/A02 cells.
, 2012 The K562 and K562/A02 cells were treated with PBS or PH II-7 (200 nM) for 48 hours, (A)Venn diagrams showing numbers of PH II-7-responsive genes in K562 and K562/A02 cells.
Yunhui Hu (179592) +14 more
core +1 more source
A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells
Cell Proliferation, EarlyView.This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang +10 more
wiley +1 more source
Antiproliferative activity of Goldfussia psilostachys ethanolic extract on K562 leukemia cells
, 2004 A dose-dependent and significant ...
Gao, XP +5 more
core
Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia
European Journal of Haematology, EarlyView.ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco +2 more
wiley +1 more source
Porphyrin synthesis and ABCB6 expression in K562 cells.
, 2012 A. ABCB6 protein expression is upregulated in parental K562 cells upon chemically induced erythroid differentiation. K562 cells were cultured for 72 h with 150 nM Gleevec or 50 µM hemin, the number of viable cells was determined by trypan-blue staining ...
Gergely Szakacs (2633) +9 more
core +1 more source