Results 111 to 120 of about 4,454,791 (262)
BMC Immunology, 2019 Background Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors.
Alexandra Tremblay-McLean +4 more
doaj +1 more source
Porphyrin synthesis and ABCB6 expression in K562 cells.
, 2012 A. ABCB6 protein expression is upregulated in parental K562 cells upon chemically induced erythroid differentiation. K562 cells were cultured for 72 h with 150 nM Gleevec or 50 µM hemin, the number of viable cells was determined by trypan-blue staining ...
Gergely Szakacs (2633) +9 more
core +1 more source
Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy
Medicine Advances, EarlyView.Pongamia pinnata phytochemicals have multiple anticancer mechanisms, including antioxidant, anti‐inflammatory, anti‐metastatic, and apoptosis‐inducing activities through molecular‐level regulation. These bioactive compounds protect normal cells from oxidative stress while promoting reactive oxygen species‐mediated tumor cell death and suppressing ...
Rajib Dhar, Vetriselvan Subramaniyan
wiley +1 more source
, 2014 A. Expression of CD56 and CD3 on peripheral blood mononuclear cells from a healthy donor was examined after 1 week (top row) of co-culture with irradiated (IR, left column) or freeze/thaw-treated (F, right column) K562-mb15-41BBL cells at a low dose (10 ...
Tsung-Hsien Chang (141335) +11 more
core +1 more source
Phytotherapy Research, EarlyView.Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo +3 more
wiley +1 more source
, 2009 Alterations in the PI3K/Akt network play important roles in the etiology, maintenance and progression of acute leukemia. The analysis of the intracellular signaling profile of leukemia patients could serve to reveal novel molecular targets for treatment ...
Missiroli, Silvia
core
Andrology, EarlyView.ABSTRACT Background Lower testosterone concentrations in older men are associated with poorer health outcomes. Objective We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing, in overweight men with impaired glucose tolerance (IGT) or newly ...
Bu B. Yeap +11 more
wiley +1 more source
Iron metabolism in K562 erythroleukemic cells.
Journal of Biological Chemistry, 1985 Iron delivery to K562 cells is enhanced by desferrioxamine through induction of transferrin receptors. Experiments were performed to further characterize this event with respect to iron metabolism and heme synthesis. In control cells, up to 85% of the iron taken up from iron-transferrin was incorporated into ferritin, 7% into heme, and the remainder ...
S S, Bottomley, L C, Wolfe, K R, Bridges
openaire +2 more sources
British Journal of Haematology, EarlyView.Summary While the majority of myeloid neoplasms are sporadic, the increasing application of germline genetic testing has led the World Health Organization to designate ‘Myeloid malignancies with germline predisposition’ as a distinct clinical entity, carrying major implications for clinical care and research.
Elena Vuelta +9 more
wiley +1 more source
Reversion of multidrug resistance in leukemia K562 cells by RNA interference targeting Apollon gene
Zhongguo aizheng zazhi, 2013 Background and purpose: Apollon gene is highly expressed in leukemia and other tumors. The study aimed to discuss whether RNAi technology can reverse multidrug resistance of chronic myeloid leukemia cell line K562 through constructing a eukaryotic vector
贾秀红, 孝飞飞, 李建厂
doaj