Results 131 to 140 of about 10,434 (197)

Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Mitotic spindles in K562 cells were altered by curcumin.

, 2016
A) Expression levels of phosphorylsted-histone 3 in serine 10 (p-H3S10) were increased in K562 cells after curcumin treatment, as determined by western blot and B) FACS analysis.
Marco Antonio Meraz-Rios (3342725), Leticia Cedillo-Barron (3342731), Emilio J. Cordova (3342728), Raul Bonilla-Moreno (3342737), Nicolas Villegas-Sepulveda (3342743), Leticia Aleman-Lazarini (3342740), Macario Martinez-Castillo (3342734), Lorena Orozco (180145)   +7 more
core   +1 more source

Study of leukemic stem cell population (CD34+/CD38-) and WT1 protein expression in human leukemic cell lines

Journal of Associated Medical Sciences, 2018
Background: Leukemic stem cells (LSCs) play a central role in relapse and refractory cases of leukemia patients. This cell has been found to resist to a conventional chemotherapy more than leukemic cells.
Pawaret Panyajai, Noppadet Amnajphook, Sommawan Keawsangthongcharoen, Sawitree Chiampanichayakul, Singkome Tima, Songyot Anuchapreeda   +5 more
doaj  

Cerium oxide nanoparticles-assisted aptasensor for chronic myeloid leukaemia detection

ADMET and DMPK
Background and purpose: Chronic myeloid leukaemia (CML) is one of the most lethal types of leukaemia and can rapidly progress if not treated properly. Therefore, having an effective diagnostic strategy is crucial.
Yuspian Nur, Yeni Wahyuni Hartati, Muhammad Ihda HL Zein, Irkham Irkham, Shabarni Gaffar, Toto Subroto   +5 more
doaj   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

The intracellular distribution of PH II-7 in K562 and K562/A02 cells and its regulation of intracellular ADM concentration in K562/A02 cells.

, 2012
(A) Synthesis of 3-nitrobenzylidene-1-(3-aminopropyl) indoline-2-one (PH II-7-NH2), and the conjugation of it with FITC. (B)The intracellular locations of PH II-7 in K562 and K562/A02 cells at 0.5 hour, 3 hours, and 5.5 hours.
Yunhui Hu (179592), Caiyun Wang (179623), Yinliang Xie (179616), Yingdai Gao (179630), Juanni Liu (179603), Yaohong Tan (179588), Yuan Zhou (179597), Jianxiang Wang (179637), Chunzheng Yang (179644), Xin Cheng (179584), Tao Cheng (131540), Hua Miao (179651), Ye Su (179577), Dongsheng Xiong (179646), Yuanfu Xu (179609)   +14 more
core   +1 more source

THAP11 accelerates megakaryocytic differentiation of K562 cells induced by PMA.

, 2014
THAP11 lentivirus infected K562 cells (THAP11-LV) and control cells were treated with 10 nM PMA for the indicated lengths of time. CD41+ cells (A) and percentage of 4N cells (B) were analyzed using FACS.
Hong-Mei Ning (538088), Jian-Jie Li (538091), Jian-Hong Zhang (446619), Yi-Qun Zhan (538092), Wei-Wei Zheng (376809), Yang Yang (45629), Rong-Hua Yin (538087), Xiao-Ming Yang (538095), Fei-Fei Xu (538090), Chang-Yan Li (538094), Xiang-Zhen Kong (5658478), Hui Chen (28597), Xiao-Ming Dong (538089), Miao Yu (199182), Chang-Hui Ge (538093)   +14 more
core   +1 more source

Knockdown of NUDT21 inhibits proliferation and promotes apoptosis of human K562 leukemia cells through ERK pathway

Cancer Management and Research, 2018
Lan Zhang, Weihua Zhang Department of Haematology, First Hospital of Shanxi Medical University, Taiyuan 030001, China Background: NUDT21 is a mammalian precursor mRNA(pre-mRNA) 3’ end processing factor and plays an important role in the selection ...
Zhang L, Zhang WH
doaj  

Chloroquine and its Effects on K562 Cells

, 2014
Chloroquine, an effective anti-malarial drug, has recently become of interest to cancer researchers. The focus of this experiment is what effect chloroquine has on K562 cells.
Thornton, Sarah Elizabeth
core  

Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway

Drug Design, Development and Therapy, 2019
Huidan Zhang,* Dongju Han,* Tongtong Lv, Kehang Liu, Yunqing Yang, Xixi Xu, Yuqing ChenDepartment of Biochemistry, Life Sciences College, Nanjing Normal University, Nanjing, People’s Republic of China*These authors contributed equally to this ...
Zhang H, Han D, Lv T, Liu K, Yang Y, Xu X, Chen Y   +6 more
doaj