Results 121 to 130 of about 4,454,791 (262)
Icaritin induces K562 cells or primary cells apoptosis.
, 2013 A. Morphological features for apoptosis in untreated and Icaritin-treated K562 cells were revealed by Hoechst 33258 staining. Condensed chromatin and apoptotic body could be found in Icaritin-treated K562 cells by fluorescence microscope (Olympus, B×50);
Xin fu Zhou (345786) +13 more
core +1 more source
Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis [PDF]
, 1994 Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and
Matt Cotten +5 more
core +1 more source
Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy
Cancer Science, EarlyView.This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang +6 more
wiley +1 more source
Expression of GFP-nectin-1 in human K562 cells.
, 2019 (A) K562 cells transiently transfected with plasmid pCK495 express nectin-1 with GFP tagged at the N-terminus. GFP-nectin-1 is expressed at the cell surface and accumulates at cell-cell contacts. Images of GFP fluorescence, magnification 40x.
Jessenia Roldan (6331394) +6 more
core +1 more source
Protein expressions of CD44, Caveolin-1, and B-catenin in K562 and K562-IR cells.
, 2020 A. CD44 immunofluorescence staining. DAPI was used for nuclear visualization. Total corrected cellular fluorescence (TCCF) intensity of CD44 immunofluorescence images (right).
Eda Acikgoz (816259) +7 more
core +1 more source
Cancer Science, EarlyView.We generated cord blood‐derived FAP‐targeted CAR NK cells and evaluated their activity against cancer‐associated fibroblasts. These cells showed antigen‐specific cytotoxicity in vitro and robust persistence in a pleural dissemination model, although in vivo anti‐CAF efficacy was limited, supporting further development of stromal‐targeted cellular ...
Takashi Hiroshima +14 more
wiley +1 more source
Journal of Associated Medical Sciences, 2018 Background: Leukemic stem cells (LSCs) play a central role in relapse and refractory cases of leukemia patients. This cell has been found to resist to a conventional chemotherapy more than leukemic cells.
Pawaret Panyajai +5 more
doaj
Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential
Clinical &Experimental Allergy, EarlyView.Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole +4 more
wiley +1 more source
K562 cells overexpressing LMW-PTP are less sensitive towards vincristine.
, 2013 (A) LMW-PTP was overexpressed in K562 and its expression was examined in the total lysate of leukemia cells. (B) K562 cells overexpression LMW-PTP (K562LMW-PTP) or not (K562WT) were treated with VCR 125 nM for 24 h and the viable cells were counted. Each
Maikel P. Peppelenbosch (33657) +8 more
core +1 more source
A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells
Cell Proliferation, EarlyView.This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang +10 more
wiley +1 more source