Results 101 to 110 of about 4,454,791 (262)

NK cells expand and interact with K562-mb15-41BBL plasma membrane particles, but not with K562-mb15-41BBL cells [PDF]

, 2016
Natural Killer (NK) cells are highly cytotoxic and specific towards certain types of cancer cells and are therefore a potential target for immunotherapy.
Lindstrom, Ryan H
core  

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Grandisin induces apoptosis in leukemic K562 cells [PDF]

, 2017
In this study, the potential antileukemic activity of grandisin, a lignan extracted from Piper solmsianum, was evaluated against the leukemic line K562.
Alane Pereira Cortez, Massuo Jorge Kato, Larissa Moreira Cleres, Higor de Oliveira Ribeiro, Marize Campos Valadares, Alexandre Pereira dos Santos, Valadares, Marize Campos, Ribeiro, Higor de Oliveira, Benfica, Polyana Lopes, Menezes, Elizabeth Gomes Paulino, Cleres, Larissa Moreira, Polyana Lopes Benfica, Lima, Eliana Martins, Eliana Martins Lima, Santos, Alexandre Pereira dos, Kato, Massuo Jorge, Cortez, Alane Pereira, Elizabeth Gomes Paulino Menezes   +17 more
core   +2 more sources

The Crude Venom of the Whitetail Lancehead, Bothrops leucurus, and Two of Its Enzymatic Components Are Selectively Cytotoxic for Glioma Cells In Vitro

Journal of Applied Toxicology, EarlyView.
ABSTRACT Malignant glioma is the most common primary brain tumor, and glioblastoma multiforme (GBM) remains its most aggressive and incurable form. Snake venoms contain bioactive compounds with promising antitumoral properties against several cancer types.
M. O. H. V. Rosário, T. M. Fucase, P. J. Spencer, J. M. Sciani, J. Clarêncio, G. Rádis‐Baptista, L. L. Casais‐e‐Silva, R. S. El‐Bachá   +7 more
wiley   +1 more source

Interleukin‐37 Enhances Liver NK Cell Cytotoxicity and Improves Recurrence‐Free Survival in Hepatocellular Carcinoma Patients

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Introduction Hepatocellular carcinoma (HCC) remains a major cause of cancer‐related mortality worldwide, and postoperative recurrence continues to limit long‐term survival. Liver‐resident natural killer (NK) cells are key effectors of antitumor immunity in the hepatic microenvironment. Interleukin‐37 (IL‐37), an anti‐inflammatory cytokine, has
Yuki Imaoka, Masahiro Ohira, Yuka Tanaka, Toshihiro Nakayama, Miho Akabane, Shinichiro Yokota, Sheri M. Krams, Olivia M. Martinez, Carlos O. Esquivel, Kazunari Sasaki, Hideki Ohdan   +10 more
wiley   +1 more source

Experimental Study on the Mechanism of Reversal of Leukemia Multidrug Resistance by Proteasome Inhibitor Bortezomib

Cancer Biology & Medicine, 2010
OBJECTIVE In this study, we applied multidrug resistant leukemia cell line expressing mdr1-mRNA to observe changes in mdr1-mRNA, the P-gp, cell cycle and apoptosis before and after bortezomib was used, in order to explore the mechanism of reversal of ...
Ying-chun LI, Hui-han WANG, Hong-yu PAN
doaj   +1 more source

Regulation of gene expression by PH II-7 in K562 and K562/A02 cells.

, 2012
The K562 and K562/A02 cells were treated with PBS or PH II-7 (200 nM) for 48 hours, (A)Venn diagrams showing numbers of PH II-7-responsive genes in K562 and K562/A02 cells.
Yunhui Hu (179592), Caiyun Wang (179623), Yinliang Xie (179616), Yingdai Gao (179630), Juanni Liu (179603), Yaohong Tan (179588), Yuan Zhou (179597), Jianxiang Wang (179637), Chunzheng Yang (179644), Xin Cheng (179584), Tao Cheng (131540), Hua Miao (179651), Ye Su (179577), Dongsheng Xiong (179646), Yuanfu Xu (179609)   +14 more
core   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Inhibition of the Nrf2-TrxR Axis Sensitizes the Drug-Resistant Chronic Myelogenous Leukemia Cell Line K562/G01 to Imatinib Treatments [PDF]

, 2019
Nuclear factor erythroid 2-related factor 2 (Nrf2) is involved in tumor drug resistance, but its role in imatinib-resistance of chronic myeloid leukemia (CML) remains elusive.
Yanhong, Tan, Jie, Xiong, Lianrong, Xu, Hongwei, Wang, Xiuhua, Chen, Mengxia, Zhu, Liqin, Yao, Yan, Zhao, Yan, Liu, Jiangfang, Feng, Fanggang, Ren, Fei, Pan   +11 more
core   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source