Results 101 to 110 of about 10,434 (197)

Experimental Study on the Mechanism of Reversal of Leukemia Multidrug Resistance by Proteasome Inhibitor Bortezomib

Cancer Biology & Medicine, 2010
OBJECTIVE In this study, we applied multidrug resistant leukemia cell line expressing mdr1-mRNA to observe changes in mdr1-mRNA, the P-gp, cell cycle and apoptosis before and after bortezomib was used, in order to explore the mechanism of reversal of ...
Ying-chun LI, Hui-han WANG, Hong-yu PAN
doaj   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Genotoxikus hatásra bekövetkező funkcionális és strukturális DNS változások = Functional and structural changes in DNA upon genotoxic effects

, 2008
Morfológiai és biokémiai vizsgálataink arra utalnak, hogy a a genotoxikus hatások kategorizálhatók az okozott kromatin változások alapján. A kemotoxikus változások potenciális diagnosztikus jelentősége miatt vizsgáltuk a nehézfémek (elsősosrban kadmium) (
Szepessy, Edit, Rőszer, Tamás, Bánfalvi, Gáspár, Jenei, Zsolt, Serfőző, Zoltán, Nagy, Gábor György, B. Kiss, Zsigmond   +6 more
core  

Immunophenotypic features of expanded NK cells (acceptor cells) and K562-antiCD19BBζ cells (feeder cells).

, 2014
A. Expression of CD56 and CD3 on peripheral blood mononuclear cells from a healthy donor was examined after 1 week (top row) of co-culture with irradiated (IR, left column) or freeze/thaw-treated (F, right column) K562-mb15-41BBL cells at a low dose (10 ...
Tsung-Hsien Chang (141335), Chien-Hui Hung (431717), Fu-Nan Cho (644083), Shuen-Kuei Liao (13428), Ying-Chung Hong (644089), Yu-Hsiang Chang (644091), Chih-Wen Shu (644084), Ming-Sun Yu (644087), Shyh-Jer Lin (644088), Ming-Chin Ko (644085), Chien-Hsun Chen (644090), Kang-Hsi Wu (644086)   +11 more
core   +1 more source

Hemin‐dependent induction and internalization of CD38 in K562 cells

Journal of Cellular Biochemistry, 2003
AbstractThe cell surface antigen, CD38, is a bifunctional ecto‐enzyme, which is predominantly expressed on hematopoietic cells during differentiation. In the present study, it is shown that hemin treatment of K562 cells gives rise to induction of enzymatic activities inherent to CD38.
Yalcintepe, L, Ercelen, S, Adin-Cinar, S, Badur, S, Tiryaki, D, Bermek, E   +5 more
openaire   +3 more sources

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

INVOLVEMENT AND ROLE OF THE PI3K/AKT NETWORK IN DIFFERENT TYPES OF LEUKEMIA CELLS BEFORE AND AFTER IN VITRO TREATMENT WITH CONVENTIONAL OR NEWLY DEVELOPED DRUGS

, 2009
Alterations in the PI3K/Akt network play important roles in the etiology, maintenance and progression of acute leukemia. The analysis of the intracellular signaling profile of leukemia patients could serve to reveal novel molecular targets for treatment ...
Missiroli, Silvia
core  

Iron metabolism in K562 erythroleukemic cells.

Journal of Biological Chemistry, 1985
Iron delivery to K562 cells is enhanced by desferrioxamine through induction of transferrin receptors. Experiments were performed to further characterize this event with respect to iron metabolism and heme synthesis. In control cells, up to 85% of the iron taken up from iron-transferrin was incorporated into ferritin, 7% into heme, and the remainder ...
S S, Bottomley, L C, Wolfe, K R, Bridges
openaire   +2 more sources

Inhibition of the Nrf2-TrxR Axis Sensitizes the Drug-Resistant Chronic Myelogenous Leukemia Cell Line K562/G01 to Imatinib Treatments

, 2019
Nuclear factor erythroid 2-related factor 2 (Nrf2) is involved in tumor drug resistance, but its role in imatinib-resistance of chronic myeloid leukemia (CML) remains elusive.
Yanhong, Tan, Jie, Xiong, Lianrong, Xu, Hongwei, Wang, Xiuhua, Chen, Mengxia, Zhu, Liqin, Yao, Yan, Zhao, Yan, Liu, Jiangfang, Feng, Fanggang, Ren, Fei, Pan   +11 more
core   +1 more source

Performance evaluation of a CD34 expression assay by digital PCR in bone marrow harvest from healthy donors

Transfusion, EarlyView.
Abstract Background The aim of this study was to investigate a CD34 expression assay as an additional tool for the total nucleated cell (TNC) count assessment in bone marrow harvest (BMH) obtained from healthy donors. Study Design and Methods Samples obtained from bone marrow donors (n = 71) were analyzed for CD34 expression using a digital PCR assay ...
Miguel Waterhouse, Anja Kaufmann, Martina David, Sabine Enger, Melanie Sieder, Darina Siegmund, Milena Pantic, Justyna Rawluk, Robert Zeiser, Claudia Wehr, Ralph Wäsch, Justus Duyster, Jürgen Finke, Chrissoula Kiote‐Schmidt   +13 more
wiley   +1 more source