Results 81 to 90 of about 41,316 (200)
Advanced Science, Volume 13, Issue 44, 7 August 2026.This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li +4 more
wiley +1 more source
Reversion of multidrug resistance in leukemia K562 cells by RNA interference targeting Apollon gene
Zhongguo aizheng zazhi, 2013 Background and purpose: Apollon gene is highly expressed in leukemia and other tumors. The study aimed to discuss whether RNAi technology can reverse multidrug resistance of chronic myeloid leukemia cell line K562 through constructing a eukaryotic vector
贾秀红, 孝飞飞, 李建厂
doaj
Iron metabolism in K562 erythroleukemic cells.
Journal of Biological Chemistry, 1985 Iron delivery to K562 cells is enhanced by desferrioxamine through induction of transferrin receptors. Experiments were performed to further characterize this event with respect to iron metabolism and heme synthesis. In control cells, up to 85% of the iron taken up from iron-transferrin was incorporated into ferritin, 7% into heme, and the remainder ...
S S, Bottomley, L C, Wolfe, K R, Bridges
openaire +2 more sources
Advanced Science, Volume 13, Issue 44, 7 August 2026.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, Volume 13, Issue 44, 7 August 2026.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
Manufacturing and clinical applications of non‐CAR‐T immune effector cells
Transfusion, EarlyView.
Thane Kubik +2 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković +6 more
wiley +1 more source
Marine Drugs, 2008 Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells.
Motomasa Kobayashi +4 more
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MicrobiologyOpen, Volume 15, Issue 4, August 2026.The dichloromethane extract (DCM‐E) was prepared from the culture supernatant of the fungus Talaromyces annesophieae MD2 was fractionated using chromatographic techniques. The subfraction 3 was determined to contain four major nitrogenous compounds and exhibit antibacterial, anticancer, antioxidant, and cytoprotective activities.
Meryem Doymus‐Yilmaz +2 more
wiley +1 more source
Journal of Associated Medical Sciences, 2018 Background: Leukemic stem cells (LSCs) play a central role in relapse and refractory cases of leukemia patients. This cell has been found to resist to a conventional chemotherapy more than leukemic cells.
Pawaret Panyajai +5 more
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