Results 81 to 90 of about 4,454,791 (262)

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells

BMC Cancer, 2007
Background The objective of this study was to gain insight into the molecular mechanism of induced cell death (apoptosis) by PYRROLO [1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) series compounds, using human (K562) cells as a model.
Morgante Emanuela, La Regina Giuseppe, Giorda Ezio, Filomeni Giuseppe, Di Renzo Livia, Catalano Gianfranco, Abruzzese Elisabetta, Silvestri Romano, Di Stefano Carla, Marfe Gabriella, Ciriolo Maria, Russo Matteo, Amadori Sergio, Sinibaldi-Salimei Paola   +13 more
doaj   +1 more source

A Real‐Data‐Driven Framework for Evaluating Differential Transcript Usage Methods Across Long‐Read Bulk, Single‐Cell, and Spatial Transcriptomics

Advanced Science, EarlyView.
Grounded in real biological RNA‐seq data, the framework benchmarks ten differential transcript usage (DTU) methods across short‐read bulk, long‐read bulk, long‐read single‐cell, and long‐read spatial transcriptomics. By integrating reference transcript sets with ranked DTU results, the Transcript Set Enrichment Score (TSES) identifies data‐type ...
Chenxing Zhang, Jun Liu, Qi Zhao, Huilong Yin, Angang Yang, Minhua Zheng, Rui Zhang   +6 more
wiley   +1 more source

Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission

Retrovirology, 2004
Background Dendritic cell (DC) transmission of human immunodeficiency virus (HIV) to CD4+ T cells occurs across a point of cell-cell contact referred to as the infectious synapse.
Breun Sabine KJ, Han Yoon-Chi, Martin Thomas D, Wu Li, KewalRamani Vineet N   +4 more
doaj   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines

Acta Pharmaceutica, 2019
Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononu-clear cells (PBMC ...
Sabran Affidah, Kumolosasi Endang, Jantan Ibrahim   +2 more
doaj   +1 more source

ACSL1 promotes imatinib-induced chronic myeloid leukemia cell senescence by regulating SIRT1/p53/p21 pathway

Scientific Reports, 2022
Although tyrosine kinase inhibitors (TKIs) improve the prognosis of chronic myeloid leukemia (CML) patients, resistance to TKIs and residual leukemia stem cells (LSCs) inevitably become the bottleneck of cure.
Wen Liu, Xiaoying Zhu, Ling Tang, Na Shen, Fanjun Cheng, Ping Zou, Yong You, Guolin Yuan, Qing Li, Xiaojian Zhu   +9 more
doaj   +1 more source

PH II-7 induces S phase cell cycle arrest in K562 and K562/A02 cells.

, 2012
(A) PH II-7 induces cell cycle S phase arrest in a concentration-dependent manner in K562 and K562/A02 cells, the cells were treated with the indicated concentrations of PH II-7 for 24 hours.
Yunhui Hu (179592), Caiyun Wang (179623), Yinliang Xie (179616), Yingdai Gao (179630), Juanni Liu (179603), Yaohong Tan (179588), Yuan Zhou (179597), Jianxiang Wang (179637), Chunzheng Yang (179644), Xin Cheng (179584), Tao Cheng (131540), Hua Miao (179651), Ye Su (179577), Dongsheng Xiong (179646), Yuanfu Xu (179609)   +14 more
core   +1 more source

Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis

Hematology
Background Imatinib (IM) is the primary treatment for patients with chronic-phase CML (CML-CP). However, an increasing number of CML-CP patients have developed resistance to IM.
Yaqin Jiang, Shishan Xiao, Shengwen Huang, Xuemei Zhao, Siruiyun Ding, Qianqian Huang, Wei Xiao, Zhe Li, Hongqian Zhu   +8 more
doaj   +1 more source

Comparative proteomic analysis of differentially expressed proteins between K562 and K562/ADM cells

Chinese Medical Journal, 2008
Multidrug resistance to chemotherapeutic agents is an important clinical problem during the treatment of leukemia. The resistance process is multifactorial. To realize the total factors involved in multidrug resistance, we analyzed the differentially expressed proteins of K562 and K562/ADM cells and we investigated one of the up-regulated proteins ...
Shao-hua, Shen, Long-jun, Gu, Pei-qing, Liu, Xin, Ye, Wei-shan, Chang, Ben-shang, Li   +5 more
openaire   +2 more sources