Results 61 to 70 of about 4,454,791 (262)

Cell cycle-independent upregulation of p27Kip1 by p21Waf1 in K562 cells [PDF]

Oncogene, 2001
Cellular differentiation frequently involves sequential peaks in the expression of cyclin-dependent kinase inhibitors (cdki's). For example, an increase in levels of the cdki p27Kip1 follows upregulation of p21Waf1 in several cell types induced to differentiate by diverse stimuli.
R A, Steinman, Y, Lu, B, Yaroslavskiy, C, Stehle   +3 more
openaire   +2 more sources

Generation of K562/ADM cells.

, 2013
(A) K562/ADM cells were established after exposure of K562 cells to ADM. MDR1 expression in parental and drug-treated K562 cells was normalized to the GAPDH housekeeping gene. (B) FACS analysis of K562 and K562/ADM cells stained with P-gp antibody.
Stephen J. Ohms (489675), Yiqiao Hu (392239), Jun Y. Fan (489677), M. Frances Shannon (6653), Zhiyong Mao (489676), Yan Xu (14594), Qiao Wang (174321), Guangming Gong (263029), Zhen Li (49109)   +8 more
core   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Tetrandrine overcomes drug resistance mediated by bone marrow microenvironment by regulating the expression of P-glycoprotein in acute leukemia

Hematology, 2022
Objectives: To study the effect of TET on the reversal of drug resistance in the bone marrow microenvironment, and to further promote the research on drug reversal.Methods: We established a co-culture system of bone marrow mesenchymal stem cells (BM-MSC)
Xinyi Zhou, Nan Jin, Baoan Chen
doaj   +1 more source

Antiproliferative activity of Goldfussia psilostachys ethanolic extract on K562 leukemia cells [PDF]

, 2004
A dose-dependent and significant ...
Gao, XP, Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Li, BG, Zhang, GL, Zhou, M, Luo, DX   +5 more
core  

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Mn-Zn ferrite nanoparticles inducing ferroptosis to reverse the resistance in CML cells

Journal of Translational Medicine
Background Chronic myeloid leukemia (CML) is a malignant clonal disease of hematopoietic stem cells driven by the BCR-ABL fusion gene. Although tyrosine kinase inhibitors (TKIs) serve as targeted therapies, drug resistance remains one of the key ...
Miao Zhu, Yanqian Zhao, Li Xu, Mei Sun, Yuxiang Sun   +4 more
doaj   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Naturally Occurring Bicoumarin Compound Daphnoretin Inhibits Growth and Induces Megakaryocytic Differentiation in Human Chronic Myeloid Leukemia Cells

Cells, 2022
Daphnoretin extracted from the stem and roots of Wikstroemia indica (L.) C.A. Mey has been shown to possess antiviral and antitumor activities. Herein, we hypothesized that daphnoretin might induce megakaryocytic differentiation, thereby inhibiting the ...
Yu-Chuen Huang, Chun-Ping Huang, Chin-Ping Lin, Kai-Chien Yang, Yu-Jie Lei, Hao-Pei Wang, Yueh-Hsiung Kuo, Yu-Jen Chen   +7 more
doaj   +1 more source

K562 cells and stiffened K562 cells separation.

, 2013
(A) Flow cytometry analyses of the initial mixture of cells and the cells collected at the stiff and soft outlets show an enrichment of both cell types at the stiff and soft outlet respectively. 4% formaldehyde treated K562 cells (E =  kPa) were enriched
Rebecca Byler (471479), Wenbin Mao (471478), Krishna Patel (471480), Caitlin Henegar (471481), Todd Sulchek (143213), Alexander Alexeev (471482), Gonghao Wang (471477)   +6 more
core   +1 more source