Results 61 to 70 of about 41,316 (200)

Comparative proteomic analysis of differentially expressed proteins between K562 and K562/ADM cells

Chinese Medical Journal, 2008
Multidrug resistance to chemotherapeutic agents is an important clinical problem during the treatment of leukemia. The resistance process is multifactorial. To realize the total factors involved in multidrug resistance, we analyzed the differentially expressed proteins of K562 and K562/ADM cells and we investigated one of the up-regulated proteins ...
Shao-hua, Shen, Long-jun, Gu, Pei-qing, Liu, Xin, Ye, Wei-shan, Chang, Ben-shang, Li   +5 more
openaire   +2 more sources

A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells

Cell Proliferation, EarlyView.
This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang, Bo Deng, Nini Guo, Yiyi Ding, Zhangjingwen Xu, Yiwen Lu, Yue Ma, Qian Ren, Nan Wang, Pengyu Huang, Xiaotong Ma   +10 more
wiley   +1 more source

Effect of interaction of magnetic nanoparticles of Fe3O4 and artesunate on apoptosis of K562 cells

International Journal of Nanomedicine, 2011
Ying Wang1, Yuxiang Han1, Yingying Yang1, Jingci Yang1, Xiaonan Guo1, Jingnan Zhang1, Ling Pan1, Guohua Xia2, Baoan Chen21Department of Hematology, the 2nd Hospital of Hebei Medical University, People’s Republic of China; 2Department of ...
Wang Y, Han Y, Yang Y, Yang J, Guo X, Zhang J, Pan L, Xia G, Chen B   +8 more
doaj  

Dengue virus infection mediates HMGB1 release from monocytes involving PCAF acetylase complex and induces vascular leakage in endothelial cells.

PLoS ONE, 2012
High mobility group box 1 (HMGB1) protein is released from cells as a pro-inflammatory cytokine in response to an injury or infection. During dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), a number of pro-inflammatory cytokines are released,
Siew Pei Ong, Ling Min Lee, Yew Fai Ivan Leong, Mah Lee Ng, Justin Jang Hann Chu   +4 more
doaj   +1 more source

iPSC‐Derived iNK Progenitors Engraft and Generate NK Cells in Unconditioned and Autologous Immune Humanized Mice

Cell Proliferation, EarlyView.
Infusion of CXCR4‐expressing iNK progenitor (iNKP) cells derived from iPSCs can continuously generate iNK cells in an unconditioned and autologous PBMC humanised hIL15 mouse model. iNKP cell therapy has the potential to treat patients without the requirement for prior lymphodepletion. ABSTRACT NK cells exhibit inherently short persistence in vivo. Allo‐
Min Zhang, Zhiqian Wang, Yanhong Liu, Leqiang Zhang, Fangxiao Hu, Chengxiang Xia, Mengyun Zhang, Tongjie Wang, Qitong Weng, Hanmeng Qi, Yanping Zhu, Lijuan Liu, Dehao Huang, Hong‐Hu Zhu, Jinyong Wang   +14 more
wiley   +1 more source

Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines

Acta Pharmaceutica, 2019
Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononu-clear cells (PBMC ...
Sabran Affidah, Kumolosasi Endang, Jantan Ibrahim   +2 more
doaj   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, EarlyView.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells

Frontiers in Oncology, 2020
The cell-microenvironment communication is essential for homing of hematopoietic stem cells in stromal niches. Recent evidences support the involvement of epithelial-to-mesenchymal (EMT) process in hematopoietic stem cell homeostasis as well as in ...
Roberta Chirillo, Ilenia Aversa, Anna Di Vito, Alessandro Salatino, Anna Martina Battaglia, Alessandro Sacco, Maddalena Adriana Di Sanzo, Maria Concetta Faniello, Maria Concetta Faniello, Barbara Quaresima, Camillo Palmieri, Flavia Biamonte, Flavia Biamonte, Francesco Costanzo, Francesco Costanzo   +14 more
doaj   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source