Results 151 to 160 of about 41,316 (200)

Stereoselective Accumulation of Propranolol Enantiomers in K562 and K562/ADR Cells

Chirality, 2013
ABSTRACTThe stereoselective uptake of propranolol enantiomers was investigated by using the K562 and K562 adriamycin‐resistant cell line (K562/ADR) as a model. An enantioselective RP‐HPLC method was applied to determine the accumulation of propranolol (PPL) stereoisomers in K562 and K562/ADR cells.
Xiao-Li, Zheng, Qin-Qin, Yu, Yi, Wang, Su, Zeng   +3 more
exaly   +3 more sources

Glycophorins of human erythroleukemic K562 cells

Archives of Biochemistry and Biophysics, 1987
Glycophorins related to alpha glycophorin, of the human erythrocyte membrane, were isolated from human erythroleukemic K562 cells. The glycophorins were purified using sodium dodecyl sulfate (SDS)/trichloroacetic acid fractionation and Folch and hot phenol extractions. 0.1-0.2 micrograms was obtained/10(8) cells, or approximately a 15% yield.
R E, Silver, A M, Adamany, O O, Blumenfeld   +2 more
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K562—A human erythroleukemic cell line

International Journal of Cancer, 1979
AbstractWe have studied the surface membrane properties of the human leukemic cell line K562 which previously has been reported to represent an early stage of granulocyte maturation. The surface glycoprotein pattern of the K562 cells obtained after galactose oxidase‐NaB[3H]4 labelling and slab gel electrophoresis shows striking similarities with that ...
L C, Andersson, K, Nilsson, C G, Gahmberg   +2 more
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Apoptosis inducing effect of meisoindigo on K562 cells

Chinese Journal of Integrated Traditional and Western Medicine, 1999
To study the effect of meisoindigo on human chronic myelogenous leukemia (CML) cell line K562 cells for exploring the mechanism of meisoindigo in treatment of CML.Multiple methods, including dose-response curve, trypan blue exclusion, cytomorphology, DNA electrophoresis, flow cytometry and TUNEL (TdT mediated dUTP nick and labeling), were used to ...
L, Song, L, Qian
openaire   +2 more sources

Megakaryoblastic differentiation of proerythroblastic K562 cell-line cells

Leukemia Research, 1984
The human proerythroblastic leukemia cell-line K562 was induced to differentiate into megakaryocytic cells by 12-O-tetradecanoylphorbol-13-acetate (TPA). Megakaryocytic differentiation was detected when lineage-specific monoclonal antibodies were used to monitor the effect of TPA on K562 cells. A monoclonal anti-platelet antibody (C17) directed against
P A, Tetteroo, F, Massaro, A, Mulder, R, Schreuder-van Gelder, A E, von dem Borne   +4 more
openaire   +2 more sources

Effects of inducers of erythroid differentiation of human leukemia K562 cells on vincristine-resistant K562/VCR cells

Leukemia Research, 1983
K562/VCR cells, which are resistant to the cytotoxicity of vincristine, were isolated from human erythroleukemia K562 cells. Various compounds that induce erythroid differentiation of K562 cells were tested on K562/VCR cells. Differentiation of K562/VCR cells was not induced by actinomycin D or adriamycin alone, but the resistance of these cells to the
J, Okabe-Kado, M, Hayashi, Y, Honma, M, Hozumi, T, Tsuruo   +4 more
openaire   +2 more sources

Mechanism of Simvastatin-Induced K562 Cell Apoptosis

Pharmacology, 2009
Statins are being widely used for the therapy and prevention of several types of tumors, including human chronic myelogenous leukemia, but the underlying molecular mechanisms still remain unknown. Therefore, inhibition of cell proliferation, apoptosis and involved molecules were investigated in K562 cells after incubation with simvastatin.The results ...
Yong-Chang, Yang, Dai-Wen, Xiao, Hua, Liu, Liang-Min, Chuan, Ya-Li, Zeng, Ding-An, Zhou, Wen, Liu, Guo-Qiang, Xu, Wen-Fang, Huang   +8 more
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Persistent infection of K562 cells by encephalomyocarditis virus

Journal of Virology, 1990
Infection of human erythroleukemic K562 cells by encephalomyocarditis virus readily resulted in establishment of persistently infected cultures. In contrast to the usual typical lytic infection by encephalomyocarditis virus, in which trypan blue staining of cells reaches close to 100% by about 15 h postinfection, K562 cell cultures required 3 to 4 days
I U, Pardoe, K K, Grewal, M P, Baldeh, J, Hamid, A T, Burness   +4 more
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Expression of C antigen in transduced K562 cells

Transfusion, 2001
BACKGROUND: The Rh blood group system is involved in HDN and transfusion reactions. A retrovirus‐expression system was previously used to show that polypeptides carrying the Rh blood group antigens are encoded by the RHD and RHCE genes. This study investigated the structure of the C antigen.STUDY DESIGN AND METHODS: K562 cells were transduced with full‐
J S, Smythe, D J, Anstee
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Reduction of extracellular dehydroascorbic acid by K562 cells

Cell Biochemistry and Function, 1996
AbstractK562 erythroleukaemic cells produced ascorbate when incubated with dehydroascorbic acid. The reduction depended on the number of cells and on the concentration of dehydroascorbic acid. The observed rate consists of a high affinity (apparent) Km 7 μM, Vmax 3·25 pmol min−1 (106 cells)−1 and a low affinity component, which was non‐saturable up to ...
E, Schweinzer, Y, Mao, P, Krajnik, N, Getoff, H, Goldenberg   +4 more
openaire   +2 more sources