Results 171 to 180 of about 10,434 (197)

Anti-cancer effects of deguelin on human leukemia K562 and K562/ADM cells In Vitro

Journal of Huazhong University of Science and Technology, 2007
In order to investigate the anti-cancer effects of deguelin and on K562 and K562/ADM cells in vitro and the underlying molecular mechanism and compare the cytotoxicity of deguelin on K562, K562/ADM cells and human peripheral blood mononuclear cells (PBMCs). The effects of deguelin on cell proliferation were assessed by MTT assay.
Qiuling, Wu, Yan, Chen, Hongli, Liu, Jing, He   +3 more
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K562 cells: a source for embryonic globin chains

Journal of Chromatography B: Biomedical Sciences and Applications, 1991
A combination of DEAE-cellulose chromatography and reversed-phase high-performance liquid chromatography (HPLC) has been used to devise a method for generating large quantities of embryonic as well as fetal globin chains. The identity of these globin chains was further confirmed by their tryptic peptide mapping. This technique could, therefore, provide
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Expression profile of Notch‐related genes in multidrug resistant K562/A02 cells compared with parental K562 cells

International Journal of Laboratory Hematology, 2010
SummaryDrug resistance is the major setback of acute myeloid leukemia (AML) therapy. Notch proteins have demonstrated functional regulation in cell proliferation, differentiation, and apoptosis and thus may affect drug resistance. Our study aimed to identify the Notch‐related gene profile in drug‐resistant AML cells and provide potential strategies for
S, Yan, D, Ma, M, Ji, D, Guo, J, Dai, P, Zhao, C, Ji   +6 more
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Geldanamycin Induces Cell Cycle Arrest in K562 Erythroleukemic Cells

IUBMB Life, 1999
AbstractGeldanamycin (GA), a benzoquinone ansamycin, is one of the specific inhibitors of 90‐kDa heat shock protein and induces growth inhibition and apoptosis in certain cancer cell lines. We have investigated the mechanism of GA‐induced growth inhibition in K562 erythroleukemic cells.
H R, Kim, C H, Lee, Y H, Choi, H S, Kang, H D, Kim   +4 more
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Stromal cell-dependent terminal maturation of K562 erythroleukaemia cells

Leukemia Research, 1991
K562 cells were cultured over monolayers of various cell types for four days and the characteristics of those cells which became firmly adherent to such monolayers studied. The monolayers used were composed of stromal cells derived from human bone marrow, two human fibroblast lines, human umbilical cord-derived endothelial cells, bone marrow ...
S R, Zuhrie, S N, Wickramasinghe
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Suppressor substance produced by the K562 cell line in vitro

Journal of Surgical Oncology, 1983
AbstractSupernatant fluids from three human cultured cell lines, K562, NALM‐1, and Daudi, all isolated from patients with lymphoreticular malignancies, were tested for suppressive activity toward normal lymphocytes in vitro. It was found that the K562 line elaborated material which effectively suppressed the response of normal human blood lymphocytes ...
J M, Korzelius, P M, Bealmear, O A, Holtermann   +2 more
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[Analysis of methylation status of the promoter of mdr1 gene in K562 and K562/DNR cells].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2008
To analyze the methylation patterns of mdr1 gene promotor in both K562 cell and K562/DNR cells and the relationship between promotor methylation and P-gp expression.mdr1 gene expression was analyzed by flow cytometry and RT-PCR, methylation status of the promotor of mdr1 gene by bisulfite-sequencing (including two GC-box).mdr1 gene was found methylated
Feng, Gao, Jing-dong, Zhang, Yun-peng, Liu, Xiang-lan, Lu   +3 more
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Erythroid properties of K562 cells

Experimental Cell Research, 1983
J.L. Villeval, P.G. Pelicci, A. Tabilio, M. Titeux, A. Henri, F. Houesche, P. Thomopoulos, W. Vainchenker, M. Garbaz, H. Rochant, J. Breton-Gorius, P.A.W. Edwards, U. Testa   +12 more
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[Screening for drug resistance related microRNAs in K562 and K562/A02 cell lines].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2016
To explore the relationship between microRNA and drug resistance in leukemia treatment by screening and identifying the microRNAs which differentially express in K562 cell line and its adriamycin resistant cells-K562/A02 cell line.The drug resistance potency of K562/A02 cells was evaluated by MTT assay.
Yi-Xiong, Cao, Chong-Wen, Dai, Guang-Sen, Zhang   +2 more
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Inhibition of human NK cell cytotoxicity against K562 cells with glycopeptides from K562 plasma membranes.

Journal of clinical & laboratory immunology, 1985
Human Natural Killer (NK) cell activity against K562 target cells has previously been shown to be inhibited by certain monosaccharides and glycoproteins in a specific fashion. Glycopeptides have been prepared from the isolated plasma membranes of cultured K562 cells by extensive pronase digestion and fractionated by lectin affinity chromatography. Nine
J M, Decker, A, Hinson, E W, Ades
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