Results 171 to 180 of about 41,316 (200)

Expression profile of Notch‐related genes in multidrug resistant K562/A02 cells compared with parental K562 cells

International Journal of Laboratory Hematology, 2010
SummaryDrug resistance is the major setback of acute myeloid leukemia (AML) therapy. Notch proteins have demonstrated functional regulation in cell proliferation, differentiation, and apoptosis and thus may affect drug resistance. Our study aimed to identify the Notch‐related gene profile in drug‐resistant AML cells and provide potential strategies for
S, Yan, D, Ma, M, Ji, D, Guo, J, Dai, P, Zhao, C, Ji   +6 more
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Geldanamycin Induces Cell Cycle Arrest in K562 Erythroleukemic Cells

IUBMB Life, 1999
AbstractGeldanamycin (GA), a benzoquinone ansamycin, is one of the specific inhibitors of 90‐kDa heat shock protein and induces growth inhibition and apoptosis in certain cancer cell lines. We have investigated the mechanism of GA‐induced growth inhibition in K562 erythroleukemic cells.
H R, Kim, C H, Lee, Y H, Choi, H S, Kang, H D, Kim   +4 more
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Stromal cell-dependent terminal maturation of K562 erythroleukaemia cells

Leukemia Research, 1991
K562 cells were cultured over monolayers of various cell types for four days and the characteristics of those cells which became firmly adherent to such monolayers studied. The monolayers used were composed of stromal cells derived from human bone marrow, two human fibroblast lines, human umbilical cord-derived endothelial cells, bone marrow ...
S R, Zuhrie, S N, Wickramasinghe
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Suppressor substance produced by the K562 cell line in vitro

Journal of Surgical Oncology, 1983
AbstractSupernatant fluids from three human cultured cell lines, K562, NALM‐1, and Daudi, all isolated from patients with lymphoreticular malignancies, were tested for suppressive activity toward normal lymphocytes in vitro. It was found that the K562 line elaborated material which effectively suppressed the response of normal human blood lymphocytes ...
J M, Korzelius, P M, Bealmear, O A, Holtermann   +2 more
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[Analysis of methylation status of the promoter of mdr1 gene in K562 and K562/DNR cells].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2008
To analyze the methylation patterns of mdr1 gene promotor in both K562 cell and K562/DNR cells and the relationship between promotor methylation and P-gp expression.mdr1 gene expression was analyzed by flow cytometry and RT-PCR, methylation status of the promotor of mdr1 gene by bisulfite-sequencing (including two GC-box).mdr1 gene was found methylated
Feng, Gao, Jing-dong, Zhang, Yun-peng, Liu, Xiang-lan, Lu   +3 more
openaire   +1 more source

[Screening for drug resistance related microRNAs in K562 and K562/A02 cell lines].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2016
To explore the relationship between microRNA and drug resistance in leukemia treatment by screening and identifying the microRNAs which differentially express in K562 cell line and its adriamycin resistant cells-K562/A02 cell line.The drug resistance potency of K562/A02 cells was evaluated by MTT assay.
Yi-Xiong, Cao, Chong-Wen, Dai, Guang-Sen, Zhang   +2 more
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Erythroid properties of K562 cells

Experimental Cell Research, 1983
J.L. Villeval, P.G. Pelicci, A. Tabilio, M. Titeux, A. Henri, F. Houesche, P. Thomopoulos, W. Vainchenker, M. Garbaz, H. Rochant, J. Breton-Gorius, P.A.W. Edwards, U. Testa   +12 more
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Inhibition of human NK cell cytotoxicity against K562 cells with glycopeptides from K562 plasma membranes.

Journal of clinical & laboratory immunology, 1985
Human Natural Killer (NK) cell activity against K562 target cells has previously been shown to be inhibited by certain monosaccharides and glycoproteins in a specific fashion. Glycopeptides have been prepared from the isolated plasma membranes of cultured K562 cells by extensive pronase digestion and fractionated by lectin affinity chromatography. Nine
J M, Decker, A, Hinson, E W, Ades
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[Effect of Stably Down-regulating FMI Expression of K562 Cells on Sensitivity of K562 cells to Imatinib Mesylate].

Zhongguo shi yan xue ye xue za zhi, 2019
To investigate the effect of stably down-regulating the FMI expression of K562 cells on the sensitivity of K562 cells to Imatinib (IM) and its possible mechanism.Western-blot was used to detect the expression of FMI protein in K562 cells and peripheral blood mononuclear cells from the patients with chronic myelogenous leukemia, chronic myeloid blast ...
Ya-Hui, Han, Huan-Xin, Zhang, Fei, Hong, Di, Yu, Chen-Yuan, Hu, Qian, Sun, Ling-Yu, Zeng, Zhen-Yu, Li, Zhi-Ling, Yan, Kai-Lin, Xu   +9 more
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[Deferoxamine induces apoptosis of K562 cells].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2011
To study the molecular mechanism of apoptosis of leukemic cells (K562 cells) induced by iron chelating agent deferoxamine (DFO).The exponentially growing K562 cells were used (1×10(6)/mL) in this study. The K562 cells were treated with different concentrations of DFO (10, 50 and 100 mmol/L), DFO+FeCl3 (10 μmol/L each) or normal saline (blank control ...
Guo-Cun, Jia, You-Cai, Tang, Feng-Yi, Li, Qing-Kui, Liao   +3 more
openaire   +1 more source