Results 181 to 190 of about 4,454,791 (262)

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. [PDF]

Int J Mol Sci, 2023
Chang YJ, Lin S, Kang ZF, Shen BJ, Tsai WH, Chen WC, Lu HP, Su YL, Chou SJ, Lin SY, Lin SW, Huang YJ, Wang HH, Chang CJ.   +13 more
europepmc   +1 more source

Effect of cortisol on K562 leukemia cell

O Mundo da Saúde, 2019
Numerous studies describe effects caused by stress on the development, progression and poor prognosis of various pathologies, such as cancer. In recent decades, researchers have investigated the role of stress-associated hormones and cancer progression. Cortisol is described as a primary stress hormone in the human body.
Marcelo de Oliveira Fonseca, Newton Soares da Silva, Cristina Pacheco Soares   +2 more
openaire   +1 more source

Unveiling the Bioactive Potential: Antiproliferative, Antimicrobial, and Antioxidant Properties of Polar Extracts From Six Ecuadorian Medicinal Flora

New Zealand Journal of Botany, Volume 64, Issue 3, September 2026.
This study validates the therapeutic potential of six Ecuadorian plants used by the Saraguro community. Key findings reveal significant antiproliferative activity in Schinus molle and Lepidium chichicara polar extracts, providing a scientific foundation for their traditional use as natural anticancer and antimicrobial agents.
María I. Ramírez, Aday González‐Bakker, Adam N. Khan, José M. Padrón   +3 more
wiley   +1 more source

Liproxstatin‑1 induces cell cycle arrest, apoptosis, and caspase‑3/GSDME‑dependent secondary pyroptosis in K562 cells. [PDF]

Int J Oncol, 2022
Dong HQ, Liang SJ, Xu YL, Dai Y, Sun N, Deng DH, Cheng P.   +6 more
europepmc   +1 more source

A Physical Organic Odyssey: From the Ultrafast Dynamics of Carbenes and Nitrenes to Contemporary Chemical Biology and Drug Discovery

Journal of Physical Organic Chemistry, Volume 39, Issue 9, September 2026.
Physical organic chemistry transforms photoaffinity labeling from empirical photochemistry into rational probe design. By measuring reactive‐intermediate lifetimes, pathways, and selectivity, Platz's legacy connects carbene and nitrene mechanisms to modern chemoproteomics, enabling more precise protein labeling and drug‐discovery maps.
Bin Yang, Jin Wang
wiley   +1 more source

Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells. [PDF]

Genes (Basel), 2022
Bernardo VS, Torres FF, de Paula CP, da Silva JPMO, de Almeida EA, da Cunha AF, da Silva DGH.   +6 more
europepmc   +1 more source

GM-K562 Cell Vaccine [PDF]

, 2020
openaire   +1 more source

Evaluation of bone preparation approaches using length‐based analysis and targeted sequencing for forensic human identification of historic skeletal remains

Journal of Forensic Sciences, Volume 71, Issue 5, Page 2040-2050, September 2026.
Abstract Advances in DNA technology have significantly enhanced the forensic community's ability to develop genetic profiles from unidentified human skeletal remains. However, sampling requires mechanical grinding of hard tissues before DNA isolation. This processing can compromise genetic profiles, particularly in aged bones.
Ciara Rhodes, Jacqueline Tyler Thomas, Kimberly Sturk‐Andreaggi, Tal Simmons, Sarah Seashols‐Williams   +4 more
wiley   +1 more source

Sirolimus modulates the erythroid differentiation of K562 cells by upregulating SHP1. [PDF]

Ann Hematol
Yang Y, Tang Z, Hu Q, Yang C, Chen M, Jing H, Han B.   +6 more
europepmc   +1 more source