Results 191 to 200 of about 4,454,791 (262)

Connexin 43-modified bone marrow stromal cells reverse the imatinib resistance of K562 cells via Ca 2+ -dependent gap junction intercellular communication. [PDF]

Chin Med J (Engl), 2023
Li X, Xiao Y, Wang X, Huang R, Wang R, Deng Y, Rao J, Gao Q, Yang S, Zhang X.   +9 more
europepmc   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, Volume 293, Issue 17, Page 5149-5169, September 2026.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Protocol to identify SINE-VNTR-Alu regulators using genome-wide screening in human K562 cells. [PDF]

STAR Protoc
Zhou Z, Zhu S, Pan D, Lee HY, Liu N.
europepmc   +1 more source

Inhibition of c-MYC-miRNA 19 Pathway Sensitized CML K562 Cells to Etoposide via NHE1 Upregulation. [PDF]

Oxid Med Cell Longev, 2022
Cao S, Xiong Q, Ding B, Wang X, Wei F, Sun Q, Yang F, Luo J, Chang G, Li S, Wang J.   +10 more
europepmc   +1 more source

WAVE2 and REST/NRSF Regulate Clustered Gene Expression by Maintaining Heterochromatin Organization

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
We identify WAVE2 as a key regulator of clustered gene expression via heterochromatin organization. Loss of WAVE2 leads to the expression of Pcdhα genes shifting from stochastic to ubiquitous isoforms, concurrent with altered promoter accessibility. REST/NRSF similarly regulates Pcdhα gene expression by organizing heterochromatin, indicating distinct ...
Leyang Wang, Yuanxiao Tang, Tianjie Li, Haiyan Huang, Qiang Wu   +4 more
wiley   +1 more source

Retraction Note: Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) induce apoptosis in K562 cells. [PDF]

BMC Cancer
Marfe G, Di Stefano C, Silvestri R, Abruzzese E, Catalano G, Di Renzo L, Filomeni G, Giorda E, Regina G, Morgante E, Ciriolo MR, Russo MA, Amadori S, Sinibaldi-Salimei P.   +13 more
europepmc   +1 more source

Synthesis and Biological Activity of 2,6‐Disubstituted and 2,6,9‐Trisubstituted 7‐Deazapurine Nucleobases

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Four series of 20 (het)aryl substituted 7‐deazapurine nucleobases were synthesized. Several potent antagonists of all four subtypes of adenosine receptors were identified by functional assay. High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7 ...
Ugnė Šinkevičiūtė, Kateřina Burgetová Ječmeňová, Soňa Gurská, Lenka Poštová Slavětínská, Vincent Baran, Pavel Polishchuk, Petr Džubák, Michal Hocek, Marián Hajdúch, Michal Tichý   +9 more
wiley   +1 more source

Insights from pooled CRISPRi single-cell screens in K562 cells reveal gene functions, regulatory networks, and highlight opportunities and limitations. [PDF]

BMC Genomics
Zhang H, Zhang P, Bindels E, Mulugeta E.
europepmc   +1 more source

Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG. [PDF]

Int J Mol Sci, 2022
Lombardi G, Latorre RV, Mosca A, Calvanese D, Tomasello L, Boni C, Ferracin M, Negrini M, Dewik NA, Yassin M, Ismail MA, Carpentieri B, Sorio C, Lecca P.   +13 more
europepmc   +1 more source

Inhibition of autophagy enhances the sensitivity of ciclopirox olamine in human chronic myelogenous leukemia K562 cells. [PDF]

Int J Med Sci
Zhou H, Chen H, Luo K, Kong L, Li Y.
europepmc   +1 more source