A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen +5 more
wiley +1 more source
Antitumor Activity and Mechanism of Action of the Antimicrobial Peptide AMP-17 on Human Leukemia K562 Cells. [PDF]
Tian Z +7 more
europepmc +1 more source
Four novel diterpenoids were isolated from Salvia rosmarinus (rosemary), together with nine known compounds. ECD calculations were employed to establish the absolute configuration of diterpenoids 1 and 2. The 18‐hydroxycarnosol (1) was evaluated as antiproliferative (SRB assay) and antioxidant (DPPH and TBARS), showing promising results.
Diana Pérez‐Juanchi +5 more
wiley +1 more source
Ketoconazole Reverses Imatinib Resistance in Human Chronic Myelogenous Leukemia K562 Cells. [PDF]
Prado-Carrillo O +6 more
europepmc +1 more source
Transcription and Three‐Dimensional Genome Organization: Cause, Consequence, or Coordination?
Transcription and 3D genome organization influence each other across spatial scales. Large‐scale architecture provides a relatively stable framework, while transcription and shared architectural factors refine local chromatin loops and domain boundaries. Specific long‐range interactions between regulatory elements and distal anchors can override domain‐
Dagyeong Yang, Elissa P. Lei
wiley +1 more source
Synergistic cytotoxicity effect of the combination of chitosan nanoencapsulated imatinib mesylate and quercetin in BCR-ABL positive K562 cells. [PDF]
Kamyabi R +3 more
europepmc +1 more source
First Report on the Phytochemical and Pharmacological Properties of Hedysarum yilmazunalii
Hedysarum yilmazunalii was collected from Erzincan, Türkiye. The leaf, stem, and root parts were then used for methanolic extraction. The extracts were analyzed for their phytochemical composition by LC–MS/MS and tested for antioxidant, enzyme inhibitory, and antiproliferative activities.
Etem Osma +7 more
wiley +1 more source
The effect of microvesicles derived from K562 cells on proliferation and apoptosis of human bone marrow mesenchymal stem cells. [PDF]
Rassaei N +6 more
europepmc +1 more source
Manufacturing and clinical applications of non‐CAR‐T immune effector cells
Transfusion, EarlyView.
Thane Kubik +2 more
wiley +1 more source
Green microwave‐ and ultrasound‐assisted synthesis enables the rapid, sustainable preparation of quinoline‐based anticancer agents with improved reaction efficiency, higher yields, and enhanced biological activity. ABSTRACT Quinoline derivatives represent a privileged class of heterocyclic compounds with remarkable structural diversity and broad ...
Rohit Pal +5 more
wiley +1 more source

